Characterising Lipid Lipolysis and Its Implication in Lipid-Based Formulation Development

No abstract is available for this paper.

• Publication year

  2012

• Venue

  AAPS Journal

• Publication date

  2012-09-07

• Fields of study

  Biology, Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1208/s12248-012-9398-6PMID 22956477PMCID PMC3475863
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011cited by this paper
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  2010cited by this paper
• Simulating fasted human intestinal fluids: understanding the roles of lecithin and bile acids.

  2010cited by this paper
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• Precipitation of a poorly soluble model drug during in vitro lipolysis: characterization and dissolution of the precipitate.

  2010cited by this paper
• Impact of emulsion-based drug delivery systems on intestinal permeability and drug release kinetics.

  2010cited by this paper
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• Biorelevant media simulating fed state intestinal fluids: colloid phase characterization and impact on solubilization capacity.

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• Bioavailability of probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state.

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• Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs.

  2008influential reference
• In vitro lipid digestion models in design of drug delivery systems for enhancing oral bioavailability

  2008cited by this paper
• The effect of different lipid based formulations on the oral absorption of lipophilic drugs: the ability of in vitro lipolysis and consecutive ex vivo intestinal permeability data to predict in vivo bioavailability in rats.

  2007influential reference
• Morphological observations on a lipid-based drug delivery system during in vitro digestion.

  2007influential reference
• Oral lipid-based formulations.

  2007influential reference
• Characterization of prototype self-nanoemulsifying formulations of lipophilic compounds.

  2007influential reference
• Low Dose Lipid Formulations: Effects on Gastric Emptying and Biliary Secretion

  2007cited by this paper
• Comparative study on digestive lipase activities on the self emulsifying excipient Labrasol, medium chain glycerides and PEG esters.

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• The Challenge of Obesity in the WHO European Region and the Strategies for Response: Summary

  2007cited by this paper
• Lipid formulation strategies for enhancing intestinal transport and absorption of P-glycoprotein (P-gp) substrate drugs: in vitro/in vivo case studies.

  2007cited by this paper
• Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs

  2007cited by this paper
• Structural Development of Self Nano Emulsifying Drug Delivery Systems (SNEDDS) During In Vitro Lipid Digestion Monitored by Small-angle X-ray Scattering

  2007cited by this paper
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  2006cited by this paper
• Use of a Dynamic in Vitro Lipolysis Model to Rationalize Oral Formulation Development for Poor Water Soluble Drugs: Correlation with in Vivo Data and the Relationship to Intra-Enterocyte Processes in Rats

  2006cited by this paper
• Bioavailability of Seocalcitol IV: Evaluation of Lymphatic Transport in Conscious Rats

  2006cited by this paper
• Monitoring of In Vitro Fat Digestion by Electron Paramagnetic Resonance Spectroscopy

  2006cited by this paper
• Monitoring drug delivery processes by EPR and related techniques--principles and applications.

  2005cited by this paper
• Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells.

  2005cited by this paper
• Influence of the intermediate digestion phases of common formulation lipids on the absorption of a poorly water-soluble drug.

  2005cited by this paper
• Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols.

  2004cited by this paper
• Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs.

  2004influential reference
• Susceptibility to Lipase-Mediated Digestion Reduces the Oral Bioavailability of Danazol After Administration as a Medium-Chain Lipid-Based Microemulsion Formulation

  2004cited by this paper
• Drug Solubilization Behavior During in Vitro Digestion of Simple Triglyceride Lipid Solution Formulations

  2004cited by this paper
• Solubilizing Excipients in Oral and Injectable Formulations

  2004influential reference
• Drug Solubilization Behavior During in Vitro Digestion of Suspension Formulations of Poorly Water-Soluble Drugs in Triglyceride Lipids

  2004cited by this paper
• Probing drug solubilization patterns in the gastrointestinal tract after administration of lipid-based delivery systems: a phase diagram approach.

  2004cited by this paper
• Using the polymer partitioning method to probe the thermodynamic activity of poorly water-soluble drugs solubilized in model lipid digestion products.

  2003cited by this paper
• “Inactive” excipients such as Cremophor can affect in vivo drug disposition

  2003cited by this paper
• Evaluation of the in‐vitro digestion profiles of long and medium chain glycerides and the phase behaviour of their lipolytic products

  2002influential reference
• A physicochemical basis for the extensive intestinal lymphatic transport of a poorly lipid soluble antimalarial, halofantrine hydrochloride, after postprandial administration to dogs.

  2002cited by this paper
• In vitro assessment of oral lipid based formulations.

  2001cited by this paper
• Intestinal lipid absorption and transport.

  2001influential reference
• Characterisation and quantification of medium chain and long chain triglycerides and their in vitro digestion products, by HPTLC coupled with in situ densitometric analysis.

  2001influential reference
• Comparison of the Lymphatic Transport of Halofantrine Administered in Disperse Systems Containing Three Different Unsaturated Fatty Acids

  2001cited by this paper
• A dynamic in vitro lipolysis model. I. Controlling the rate of lipolysis by continuous addition of calcium.

  2001influential reference
• A dynamic in vitro lipolysis model. II: Evaluation of the model.

  2001cited by this paper
• Digestive lipases: from three-dimensional structure to physiology.

  2000cited by this paper
• Human pancreatic lipase: colipase dependence and interfacial binding of lid domain mutants.

  1999cited by this paper
• Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine

  1998cited by this paper
• Modification of a phospholipid stabilized emulsion interface by bile salt: effect on pancreatic lipase activity.

  1998influential reference
• Structure and function of gastro-intestinal lipases

  1997cited by this paper
• Lipid-based vehicles for the oral delivery of poorly water soluble drugs

  1997cited by this paper
• Structure and function of pancreatic lipase and colipase.

  1997cited by this paper
• Influence of lipolysis on drug absorption from the gastro-intestinal tract

  1997cited by this paper
• Reduced inter- and intraindividual variability in cyclosporine pharmacokinetics from a microemulsion formulation.

  1994cited by this paper
• Improved Dose Linearity of Cyclosporine Pharmacokinetics from a Microemulsion Formulation

  1994cited by this paper
• Pancreatic colipase. Structural and physiological aspects.

  1992cited by this paper
• Effects of droplet size, triacylglycerol composition, and calcium on the hydrolysis of complex emulsions by pancreatic lipase : an in vitro study

  1992cited by this paper
• Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 1. Phase behavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings.

  1990cited by this paper
• Upper Gastrointestinal (GI) pH in Young, Healthy Men and Women

  1990cited by this paper
• The Role of Calcium Ions and Bile Salts on the Pancreatic Lipase-Catalyzed Hydrolysis of Triglyceride Emulsions Stabilized with Lecithin

  1989cited by this paper
• Lingual and gastric lipases: species differences in the origin of prepancreatic digestive lipases and in the localization of gastric lipase.

  1988cited by this paper
• In Vivo Model for Ciclosporin Intestinal Absorption in Lipid Vehicles

  1988cited by this paper
• Lingual lipase in cystic fibrosis. Quantitation of enzyme activity in the upper small intestine of patients with exocrine pancreatic insufficiency.

  1984cited by this paper
• Lipid digestion and absorption.

  1983cited by this paper
• The importance of bile salt for the reactivation of pancreatic lipase by colipase.

  1983cited by this paper
• Inhibition of human pancreatic lipase-colipase activity by mixed bile salt-phospholipid micelles.

  1981cited by this paper
• Studies on the substrate specificity of a carboxyl ester hydrolase from human pancreatic juice. II. Action on cholesterol esters and lipid-soluble vitamin esters.

  1980cited by this paper
• Watching fat digestion.

  1979influential reference
• Influence of Food on the Bioavailability of Drugs

  1978cited by this paper
• Isolation and properties of the mixed lipid micelles present in intestinal content during fat digestion in man.

  1975cited by this paper
• INFLUENCE OF BILE SALT, PH, AND TIME ON THE ACTION OF PANCREATIC LIPASE; PHYSIOLOGICAL IMPLICATIONS.

  1964cited by this paper
• Fat Absorption Studies in the Diagnosis and Treatment of Pancreatic Fibrosis

  1955cited by this paper
• Route of absorption and distribution of oleic acid and triolein in the rat.

  1954cited by this paper
• Intestinal lymph as pathway for transport of absorbed fatty acids of different chain lengths.

  1951cited by this paper

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