Role of L-asparaginase in acute lymphoblastic leukemia: focus on adult patients

Correspondence: Michael E Rytting Department of Pediatrics and Leukemia, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 87, Houston, TX, USA Email mrytting@mdanderson.org Abstract: Asparaginase preparations deplete asparagine in acute lymphoblastic leukemia (ALL) blasts. Asparaginase in its various forms is an important component of treatment regimens for pediatric ALL. Recently, interest and use of asparaginase in adult patients with ALL has increased, particularly in young adults. There is much less information on asparaginase use and toxicity in adult compared with pediatric populations. This review surveys prior published studies of the three most commonly used asparagine preparations as used in adult patients, and discusses important toxicities encountered in adult patients who receive asparaginase preparations.

• Publication year

  2012

• Venue

  Unknown venue

• Publication date

  2012-06-29

• Fields of study

  Medicine

• Identifiers
  DOI 10.2147/BLCTT.S18699
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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