Activated α2Macroglobulin Increases β-Amyloid (25–35)-Induced Toxicity in LAN5 Human Neuroblastoma Cells

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Experimental Neurology

• Publication date

  1999-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/EXNR.1998.6978
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• α2‐Macroglobulin Attenuates β‐Amyloid Peptide 1–40 Fibril Formation and Associated Neurotoxicity of Cultured Fetal Rat Cortical Neurons

  1998cited by this paper
• 28. – Transforming Growth Factor β1

  1998cited by this paper
• The Pathogenesis of Senile Plaques

  1997cited by this paper
• Modulation of the alpha 2 macroglobulin receptor/low density lipoprotein receptor related protein by interferon-gamma in human astroglial cells.

  1997cited by this paper
• Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease.

  1997cited by this paper
• The subunits of α2-macroglobulin receptor/low density lipoprotein receptor-related protein, native and transformed α2-macroglobulin and interleukin 6 in Alzheimer's disease

  1997cited by this paper
• Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E

  1997cited by this paper
• Colocalization of Lysosomal Hydrolase and β-Amyloid in Diffuse Plaques of the Cerebellum and Striatum in Alzheimer's Disease and Down's Syndrome

  1996cited by this paper
• Transforming growth factor beta regulates differentiation and proliferation of human neuroblastoma.

  1996cited by this paper
• Degradation of Amyloid -Protein by a Serine Protease--Macroglobulin Complex (*)

  1996cited by this paper
• Alpha 2-macroglobulin: a binding protein for transforming growth factor-beta and various cytokines.

  1996cited by this paper
• α1-Antichymotrypsin interaction with Aβ(1–42) does not inhibit fibril formation but attenuates the peptide toxicity

  1996cited by this paper
• Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons.

  1996cited by this paper
• Transforming growth factors-β protect primary rat hippocampal neuronal cultures from degeneration induced by β-amyloid peptide

  1996cited by this paper
• LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation.

  1995cited by this paper
• α2-Macroglobulin Functions as a Cytokine Carrier to Induce Nitric Oxide Synthesis and Cause Nitric Oxide-dependent Cytotoxicity in the RAW 264.7 Macrophage Cell Line (*)

  1995cited by this paper
• Glial cytokines in Alzheimer's disease: review and pathogenic implications.

  1995cited by this paper
• Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells.

  1995cited by this paper
• Evaluation of the number of positive cells from flow cytometric immunoassays by mathematical modeling of cellular autofluorescence.

  1994cited by this paper
• Neurotrophin binding to human alpha 2-macroglobulin under apparent equilibrium conditions.

  1994cited by this paper
• Classification of alpha 2-macroglobulin-cytokine interactions based on affinity of noncovalent association in solution under apparent equilibrium conditions.

  1994cited by this paper
• Secreted Forms of β-Amyloid Precursor Protein Protect Hippocampal Neurons against Amyloid β-Peptide-Induced Oxidative Injury

  1994cited by this paper
• Interferon gamma up-regulates alpha 2 macroglobulin expression in human astrocytoma cells.

  1994cited by this paper
• Transforming Growth Factor-β1 Prevents Glutamate Neurotoxicity in Rat Neocortical Cultures and Protects Mouse Neocortex from Ischemic Injury in vivo

  1993cited by this paper
• Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions.

  1993cited by this paper
• Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease

  1993cited by this paper
• Lactotransferrin immunocytochemistry in Alzheimer and normal human brain.

  1993cited by this paper
• α2-macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease

  1993cited by this paper
• α1-Trypsin Immunoreactivity in Alzheimer Disease

  1993cited by this paper
• Transforming growth factor-β1 is in plaques in Alzheimer and Down pathologies

  1993cited by this paper
• Detection of interleukin-6 and alpha 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients.

  1992cited by this paper
• Alzheimer's disease: a cell biological perspective.

  1992cited by this paper
• Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system.

  1991cited by this paper
• Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices.

  1991cited by this paper
• Immunolocalization of transforming growth factor-beta 1 in the bovine adrenal cortex using antipeptide antibodies.

  1991cited by this paper
• Differential inhibition of transforming growth factor beta 1 and beta 2 activity by alpha 2-macroglobulin.

  1990cited by this paper
• Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill.

  1989cited by this paper
• An improved method of purification of transforming growth factor, type beta from platelets.

  1988cited by this paper
• Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease.

  1988cited by this paper
• Amine accumulation in Parkinson's disease and other disorders.

  1987cited by this paper
• Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

  1987cited by this paper
• Evidence for similar conformational changes in alpha 2-macroglobulin on reaction with primary amines or proteolytic enzymes.

  1982cited by this paper
• [54] α2-Macroglobulin

  1981cited by this paper
• The degradation of articular collagen by neutrophil proteinases.

  1977cited by this paper
• Further studies on the NADH oxidase of the cytoplasmic membrane of Mycobacterium tuberculosis.

  1970cited by this paper

• Thrombin regulates the ability of Schwann cells to support neuritogenesis and to maintain the integrity of the nodes of Ranvier

  2020cites this paper
• Neuroinflammation, Microglia, and Cell-Association during Prion Disease

  2019cites this paper
• Prion Infection of Mouse Brain Reveals Multiple New Upregulated Genes Involved in Neuroinflammation or Signal Transduction

  2014cites this paper
• alpha2-Macroglobulin induces glial fibrillary acidic protein expression mediated by low-density lipoprotein receptor-related protein 1 in Müller cells.

  2011cites this paper
• Interaction of α-2-macroglobulin and HSV-1 during infection of neuronal cells

  2011cites this paper
• Alpha-2-Macroglobulin: an abundant extracellular chaperone

  2008cites this paper
• Perichondrial-mediated TGF-beta regulation of cartilage growth in avian long bone development.

  2008cites this paper
• α2-Macroglobulin Is a Mediator of Retinal Ganglion Cell Death in Glaucoma*

  2008cites this paper
• Angiogenesis inhibitors found within the haemostasis pathway

  2005cites this paper
• Increased Extracellular Amyloid Deposition and Neurodegeneration in Human Amyloid Precursor Protein Transgenic Mice Deficient in Receptor-Associated Protein

  2002cites this paper
• Distinct Binding Sites in the Structure of α2-Macroglobulin Mediate the Interaction with β-Amyloid Peptide and Growth Factors*

  2002cites this paper
• Role of α2‐macroglobulin in regulating amyloid β‐protein neurotoxicity: protective or detrimental factor?

  2001cites this paper
• Antisense strategies for the treatment of neurological disease

  2001cites this paper
• Regulation of Transforming Growth Factor-β Signaling

  2001cites this paper
• Interactions of α2-macroglobulin and amyloid β peptide

  2001cites this paper
• Identical or Overlapping Sequences in the Primary Structure of Human α2-Macroglobulin Are Responsible for the Binding of Nerve Growth Factor-β, Platelet-derived Growth Factor-BB, and Transforming Growth Factor-β*

  2000cites this paper
• α2-Macroglobulin in late-onset Alzheimer's disease

  2000cites this paper
• Fibrillar islet amyloid polypeptide differentially affects oxidative mechanisms and lipoprotein uptake in correlation with cytotoxicity in two insulin-producing cell lines.

  2000cites this paper
• A 16‐amino acid peptide from human α2‐macroglobulin binds transforming growth factor‐β and platelet‐derived growth factor‐BB

  2000cites this paper