Microflow Fluorinations of Benzynes: Efficient Synthesis of Fluoroaromatic Compounds.

Fluorinated aromatic compounds are found in a variety of biologically active compounds, including clinical drugs and agrochemicals. Therefore, the synthesis of aryl fluorides is particularly important in the medicinal and process chemistry fields. In this paper, we report a method for the synthesis of aryl fluorides by benzyne fluorination under microflow conditions using the efficient Comet X-01 micromixer. In comparison to our previously reported method under ordinary batch conditions, this approach facilitates a significant reduction in reaction times, to ca. 10 s, as well as increases in the yields of fluoroarenes (by up to 51%).

• Publication year

  2018

• Venue

  Chemical and pharmaceutical bulletin

• Publication date

  2018-12-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1248/cpb.c18-00578PMID 30504631
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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