Molecular types of Cryptococcus species isolated from patients with cryptococcal meningitis in a Brazilian tertiary care hospital

There are limited data on the molecular epidemiology of cryptococcosis in Brazil. Here, we report on the identification of the molecular pattern of the Cryptococcus species that caused meningitis in patients admitted in a Brazilian reference tertiary care hospital, and review the published studies addressing the molecular epidemiology of Cryptococcus in Brazil. Our study has shown the predominance of molecular type VNII in HIV-infected patients with cryptococcal meningoencephalitis. Molecular types VNII and VGII were occasionally detected in HIV-infected and non-infected patients with meningoencephalitis. In contrast, previous studies have shown that several regions exhibited a high prevalence of the VNI molecular type and sporadic cases of the VNII and VGII molecular types in patients with cryptococcosis in Brazil. Additional studies including VNII isolates will contribute to understanding the epidemiology and phylogenetic relationship of these genotype compared to the other ones. So far, no clear correlation has been established between genotypes, antifungal susceptibility for Cryptococcus and clinical outcome in cryptococcosis.

• Publication year

  2018

• Venue

  Brazilian Journal of Infectious Diseases

• Publication date

  2018-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.bjid.2018.11.002PMID 30508502PMCID 9425640
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genotypic analysis of clinical and environmental Cryptococcus neoformans isolates from Brazil reveals the presence of VNB isolates and a correlation with biological factors

  2018cited by this paper
• Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal.

  2018cited by this paper
• Molecular characterization and antifungal susceptibility testing of Cryptococcus neoformans sensu stricto from southern Brazil

  2018cited by this paper
• The Case for Adopting the “Species Complex” Nomenclature for the Etiologic Agents of Cryptococcosis

  2017cited by this paper
• The epidemiology of cryptococcosis and the characterization of Cryptococcus neoformans isolated in a Brazilian University Hospital

  2017cited by this paper
• MLST-Based Population Genetic Analysis in a Global Context Reveals Clonality amongst Cryptococcus neoformans var. grubii VNI Isolates from HIV Patients in Southeastern Brazil

  2017cited by this paper
• ANTIFUNGAL SUSCEPTIBILITY TESTING AND GENOTYPING CHARACTERIZATION OF Cryptococcus neoformans AND gattii ISOLATES FROM HIV-INFECTED PATIENTS OF RIBEIRÃO PRETO, SÃO PAULO, BRAZIL

  2016cited by this paper
• Cryptococcosis

  2014cited by this paper
• Molecular typing and in vitro antifungal susceptibility of Cryptococcus spp from patients in Midwest Brazil.

  2014cited by this paper
• Multilocus Sequence Typing of Serially Collected Isolates of Cryptococcus from HIV-Infected Patients in South Africa

  2014cited by this paper
• Global Molecular Epidemiology of Cryptococcus neoformans and Cryptococcus gattii: An Atlas of the Molecular Types

  2013cited by this paper
• Molecular characterisation of the causative agents of Cryptococcosis in patients of a tertiary healthcare facility in the state of Amazonas‐Brazil

  2012cited by this paper
• Characterization of clinical isolates of the Cryptococcus neoformans-Cryptococcus gattii species complex from the Amazonas State in Brazil.

  2012cited by this paper
• Microbiological characteristics of clinical isolates of Cryptococcus spp. in Bahia, Brazil: molecular types and antifungal susceptibilities

  2012cited by this paper
• Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí (northeastern Brazil).

  2011cited by this paper
• Molecular typing and antifungal susceptibility of clinical and environmental Cryptococcus neoformans species complex isolates in Goiania, Brazil

  2010cited by this paper
• Genotype and mating type distribution within clinical Cryptococcus neoformans and Cryptococcus gattii isolates from patients with cryptococcal meningitis in Uberaba, Minas Gerais, Brazil.

  2010cited by this paper
• Regional pattern of the molecular types of Cryptococcus neoformans and Cryptococcus gattii in Brazil.

  2008cited by this paper
• Genotyping, serotyping and determination of mating-type of Cryptococcus neoformans clinical isolates from São Paulo State, Brazil.

  2007cited by this paper
• Molecular epidemiology of Cryptococcus neoformans isolates from AIDS patients of the Brazilian city, Rio de Janeiro.

  2004cited by this paper
• Molecular typing of clinical and environmental Cryptococcus neoformans isolates in the Brazilian state Rio Grande do Sul.

  2003cited by this paper
• Molecular Typing of IberoAmerican Cryptococcus neoformans Isolates

  2003cited by this paper
• Hybrid genotypes in the pathogenic yeast Cryptococcus neoformans.

  2001cited by this paper
• Epidemiology: surveillance of fungal infections.

  2000cited by this paper
• Cryptococcus neoformans var.grubii: Separate Varietal Status for Cryptococcus neoformans Serotype A Isolates

  1999cited by this paper
• Molecular epidemiology of Cryptococcus neoformans in Brazil and the United States: evidence for both local genetic differences and a global clonal population structure

  1997cited by this paper
• Identification by random amplification of polymorphic DNA of a common molecular type of Cryptococcus neoformans var. neoformans in patients with AIDS or other immunosuppressive conditions.

  1996cited by this paper
• Diversity of DNA fingerprints in Cryptococcus neoformans

  1995cited by this paper
• Restriction fragment length polymorphism analysis of Cryptococcus neoformans isolates from environmental (pigeon excreta) and clinical sources in New York City

  1994cited by this paper
• Karyotyping of Cryptococcus neoformans as an epidemiological tool

  1993cited by this paper
• A new species of Filobasidiella, the sexual state of Cryptococcus neoformans B and C serotypes.

  1976cited by this paper
• A new genus, filobasidiella, the perfect state of Cryptococcus neoformans.

  1975cited by this paper
• CRYPTOCOCCOSIS

  1959cited by this paper

• Molecular characterization of clinical and environmental isolates from the Cryptococcus neoformans/C. Gattii species complexes of Maceió, Alagoas, Brazil

  2024cites this paper
• Comparative analysis of diagnostic methods for the detection of Cryptococcus neoformans meningitis

  2023cites this paper
• Molecular typing and antifungal susceptibility of clinical isolates of Cryptococcus neoformans and Cryptococcus gattii species complexes from the National Invasive Fungal Surveillance Network of Uruguay.

  2023cites this paper
• Mixed infection by Cryptococcus neoformans and Cryptococcus gattii and coinfection with paracoccidioidomycosis in PLHIV

  2022cites this paper
• Early clinical and microbiological predictors of outcome in hospitalized patients with cryptococcal meningitis

  2022cites this paper
• Cryptococcus spp. and Cryptococcosis: focusing on the infection in Brazil

  2022cites this paper
• Cryptococcus neoformans and Cryptococcus gattii Species Complexes in Latin America: A Map of Molecular Types, Genotypic Diversity, and Antifungal Susceptibility as Reported by the Latin American Cryptococcal Study Group

  2021cites this paper
• Repurposing benzimidazoles to fight Cryptococcus

  2021cites this paper
• UNIVERSIDADE FEDERAL DO RIO GRANDE DO NORTE INSTITUTO METRÓPOLE DIGITAL PROGRAMA DE PÓS-GRADUAÇÃO EM BIOINFORMÁTICA

  2020cites this paper
• Transmission of cryptococcosis by liver transplantation: A case report and review of literature.

  2020cites this paper
• Clinical and microbiological characteristics of cryptococcosis at an university hospital in China from 2013 to 2017

  2019cites this paper