Renalase, a new secretory enzyme: Its role in hypertensive-ischemic cardiovascular diseases

Renalase, a novel amine oxidase, is mainly expressed in the kidney, heart, and skeletal muscle. It has been known to degrade circulating catecholamines and plays a crucial role in human diseases. Recent studies have demonstrated its structure, unique bioactivities, function, and the gene polymorphisms in human diseases. In this review, we summarize the effects of renalase on hypertension, myocardial ischemia, acute kidney injury (AKI), ischemic stroke, cardiac dysfunction, organ transplantation, and diabetes mellitus reported in numerous studies.

• Publication year

  2014

• Venue

  Medical Science Monitor

• Publication date

  2014-04-25

• Fields of study

  Medicine

• Identifiers
  DOI 10.12659/MSM.890261PMID 24762661PMCID 4005863
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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