A new approach for the investigation of isoprenoid biosynthesis featuring pathway switching, deuterium hyperlabeling, and 1H NMR spectroscopy. The reaction mechanism of a novel streptomyces diterpene cyclase.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Organic Chemistry

• Publication date

  2003-02-08

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/JO026728APMID 12839434
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functional Analysis of Eubacterial Diterpene Cyclases Responsible for Biosynthesis of a Diterpene Antibiotic, Terpentecin*

  2002cited by this paper
• New approach to multiply deuterated isoprenoids using triply engineered Escherichia coli and its potential as a tool for mechanistic enzymology.

  2001cited by this paper
• Cloning of a Gene Cluster Encoding Enzymes Responsible for the Mevalonate Pathway from a Terpenoid-antibiotic-producing Streptomyces Strain

  2001cited by this paper
• Eubacterial Diterpene Cyclase Genes Essential for Production of the Isoprenoid Antibiotic Terpentecin

  2001cited by this paper
• Cloning of the gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from terpenoid antibiotic-producing Streptomyces strains

  2000cited by this paper
• Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs.

  1999cited by this paper
• Purification, Characterization, and Cloning of a Eubacterial 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase, a Key Enzyme Involved in Biosynthesis of Terpenoids

  1999cited by this paper
• Isoprenoid biosynthesis: manifold chemistry catalyzed by similar enzymes.

  1998cited by this paper
• Plant terpenoid synthases: molecular biology and phylogenetic analysis.

  1998cited by this paper
• Isopentenyl diphosphate isomerase: a core enzyme in isoprenoid biosynthesis. A review of its biochemistry and function.

  1997cited by this paper
• Polyprenyl diphosphate synthases.

  1997cited by this paper
• Cloning and nucleotide sequence of the gene responsible for chlorination of tetracycline.

  1995cited by this paper
• UCT4B, a new antitumor antibiotic with topoisomerase II mediated DNA cleavage activity. Structure determination.

  1993cited by this paper
• Clerodane diterpenoids.

  1992cited by this paper
• Isolation and characterization of terpentecin, a new antitumor antibiotic.

  1985cited by this paper

• Elucidation of Organic Reaction Mechanisms Using Nuclear Magnetic Resonance: A review

  2024cites this paper
• Product Rearrangement from Altering a Single Residue in the Rice syn-Copalyl Diphosphate Synthase

  2016cites this paper
• Identification of a New Diterpene Biosynthetic Gene Cluster that Produces O‐Methylkolavelool in Herpetosiphon aurantiacus

  2015cites this paper
• Peltate glandular trichomes of Colquhounia seguinii harbor new defensive clerodane diterpenoids.

  2014cites this paper
• Bacterial transformation of terpenoids

  2014cites this paper
• 1.22 – Isoprenoid in Actinomycetes

  2010cites this paper
• Isoprenoid in Actinomycetes

  2010cites this paper
• Substrate specificity of the CYC2 enzyme from Kitasatospora griseola: production of sclarene, biformene, and novel bicyclic diterpenes by the enzymatic reactions of labdane- and halimane-type diterpene diphosphates

  2010cites this paper
• Biomimetic rearrangements of simplified labdane diterpenoids

  2010cites this paper
• cis-Clerodane diterpenoids from the liverwort Gottschelia schizopleura and their cytotoxic activity.

  2009cites this paper
• cis-Clerodane Diterpenoids from the Liverwort Gottschelia schizopleura and their Cytotoxic Activity

  2009cites this paper
• Metabolite and isotopologue profiling in plants. Studies on the biosynthesis of terpenoids and alkaloids.

  2008cites this paper
• Nuclear magnetic resonance spectroscopy in biosynthetic studies

  2007cites this paper
• Preparation of highly deuterated zeaxanthin, lycopene, and β-carotene from fully deuterated mevalonate using engineered Escherichia coli

  2005cites this paper
• Biosynthesis of irregular diterpenes in Anisotome lyallii by head-to-head coupling of geranyl diphosphate.

  2005cites this paper
• Practical enantioselective synthesis of fully deuterated (R)-mevalonolactone

  2003cites this paper