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STUDY OF THE ANTICANCER POTENTIAL OF CELERY SEED OIL AGAINST CHEMICALLY INDUCED HEPATOCELLULAR CARCINOMA IN RATS: A MECHANISTIC APPROACH.

Omaima A. Ahmedy

Published 2016 in Unknown venue

ABSTRACT

Hepatocellular carcinoma (HCC), the major primary malignant tumour of the liver, represents a complex and fatal malignancy driven primarily by oxidative stress and inflammation. Celery seed oil (CSO) is a rich source of phytochemicals endowed with potent antioxidant and anti-inflammatory properties. In this study, we examined the molecular mechanisms by which CSO inhibited diethylnitrosamine (DENA)induced hepatocellular carcinoma in rats by analysing the expression patterns of proliferating cell nuclear antigen (PCNA), nuclear factor-kappaB (NF-kB), cyclooxygenase-2 (COX-2), and caspase-3 immunohistochemically. In addition, serum TNF-α level and liver nitric oxide content were investigated. Rats were administered CSO (300 mg/kg, p.o.) four weeks after DENA-induced HCC. There was a significant elevation in serum TNF-α level and liver nitric oxide content, upregulation of PCNA, NF-kB and COX-2 in DENA-exposed rats. Administration of CSO decreased the expression of PCNA and increased the expression of caspase-3, indicating antiproliferative and apoptotic effects, respectively. Moreover, CSO markedly suppressed all aforementioned elevated inflammatory parameters. Our study provides evidence that CSO exerts its anticancer effect through antiproliferative, proapoptotic and anti-inflammatory mechanisms.

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