Renal clearance of endogenous creatinine, urea, sodium, and potassium in normal cats and cats with chronic renal failure.

The renal clearance test was carried out in 6 normal male cats and 12 male cats with chronic renal failure. The average concentrations of creatinine (Cr), urea, sodium (Na), and potassium (K) in the serum of the cats with chronic renal failure were 5.09, 136.7 (mg/100 ml), 143.9 and 3.71 (mEq/l) respectively, and the specific gravity of urine was 1.009. The renal clearances of Cr, urea, Na, and K (ml/min/kg of body weight) were 2.639 +/- 0.217, 1.034 +/- 0.110, 0.024 +/- 0.007 and 0.266 +/- 0.028, respectively in normal cats, and were 0.789 +/- 0.407, 0.358 +/- 0.211, 0.095 +/- 0.084 and 0.872 +/- 0.204 in cats with chronic renal failure. Clearance of Cr and urea was significantly lower in cats with chronic renal failure than in normal cats, while the values of Na and K were significantly higher in cats with chronic renal failure. The glomerular filtration of Cr and urea and the urinary excretion of these 4 substances were significantly higher in cats with chronic renal failure. The tubular reabsorption rates of Na and K were significantly lower in cats with chronic renal failure compared to those in normal cats, but there was no significant difference in urea and creatinine.

• Publication year

  1997

• Venue

  Journal of Veterinary Medical Science

• Publication date

  1997-07-25

• Fields of study

  Medicine

• Identifiers
  DOI 10.1292/JVMS.59.509PMID 9271443
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Plasma methylguanidine and creatinine concentrations in cats with experimentally induced acute renal failure.

  1995cited by this paper
• Changes in renal function associated with treatment of hyperthyroidism in cats.

  1994cited by this paper
• Development of chronic renal disease in cats fed a commercial diet.

  1993cited by this paper
• Systemic toxicity associated with doxorubicin administration in cats.

  1993cited by this paper
• Effects of dietary protein and calorie restriction in clinically normal cats and in cats with surgically induced chronic renal failure.

  1993cited by this paper
• Correlation of urine protein/creatinine ratio and twenty-four-hour urinary protein excretion in normal cats and cats with surgically induced chronic renal failure.

  1992cited by this paper
• Quantitative renal scintigraphic determination of the glomerular filtration rate in cats with normal and abnormal kidney function, using 99mTc-diethylenetriaminepentaacetic acid.

  1992cited by this paper
• Comparison of four methods of estimating glomerular filtration rate in cats.

  1991cited by this paper
• Hypokalemia in cats: 186 cases (1984-1987).

  1989cited by this paper
• Noradrenaline as a possible mediator in the renal response to vascular expansion with blood in the cat.

  1988cited by this paper
• Potassium depletion in cats: renal and dietary influences.

  1987influential reference
• Management of acute illness in cats.

  1984cited by this paper
• Mechanism of urinary excretion of creatinine by the cat.

  1982cited by this paper
• Effect of haemorrhage on renin concentration in superficial and deep venous outflows of the cat kidney.

  1981cited by this paper
• Simple, accurate method for clinical estimation of glomerular filtration rate in the dog.

  1981cited by this paper
• Evidence supporting a proposed mechanism explaining the inverse relationship between guanidinoacetate and guanidinosuccinate in human urine.

  1975cited by this paper
• The clearance of creatinine, inulin, para-aminohippurate and phenosulphothalein in the cat.

  1970cited by this paper
• Guanidinosuccinic aciduria in uremia. A possible alternate pathway for urea synthesis.

  1968cited by this paper
• Guanidino succinic acid in uremia

  1968cited by this paper
• A new simple semimicro method for colorimetric determination of urea.

  1963cited by this paper
• A microcolorimetric determination of creatine in urine by the Jaffe reaction.

  1954cited by this paper
• Diseases of the urinary system.

  1951influential reference

• Short-term effects of orchiectomy on the health condition and renal handling of electrolytes in sexually intact adult male cats

  2025influential citation
• Efficacy of oral AB070597 for the management of chronic kidney disease in cats: a prospective, randomised, controlled parallel-group study

  2024cites this paper
• Pathogenesis and methods of diagnosis of chronic kidney disease in cats: retrospective analysis (1981–2007)

  2021cites this paper
• Substantiation of the perspectivity of improving of the population informing about the criteria of the correct choice of modern multivitamin drugs

  2021cites this paper
• Effects of a nutrient-enriched water on water intake and indices of hydration in healthy domestic cats fed a dry kibble diet.

  2018cites this paper
• Physiological, hematological and biochemical factors associated with high-altitude headache in young Chinese males following acute exposure at 3700 m

  2018cites this paper
• Effect of a high phosphorus diet on indicators of renal health in cats

  2017cites this paper
• Nile crocodile (Crocodylus niloticus) urine as sample for biochemical and hormonal analyses

  2017cites this paper
• ISFM Consensus Guidelines on the Diagnosis and Management of Feline Chronic Kidney Disease

  2016cites this paper
• Clinical Approach to Advanced Renal Function Testing in Dogs and Cats.

  2015cites this paper
• Clinical approach to advanced renal function testing in dogs and cats.

  2013cites this paper
• An overview of glomerular filtration rate testing in dogs and cats.

  2011cites this paper
• Development and validation of a timed urinary collection system for use in the cat

  2011cites this paper
• The effects of rheum officinale on the progression of feline chronic kidney disease.

  2011cites this paper
• Quantitative assessment of urea generation and elimination in healthy dogs and in dogs with chronic kidney disease.

  2010cites this paper
• Homocysteine levels in cats with chronic renal failure.

  2009cites this paper
• Kidney Function and Damage

  2008cites this paper
• Pharmacokinetics of ceftazidime after intravenous and intramuscular administration to domestic cats.

  2008cites this paper
• Fractional excretion tests: a critical review of methods and applications in domestic animals.

  2008cites this paper
• Disposition of plasma creatinine in non-azotaemic and moderately azotaemic cats

  2007cites this paper
• The bioavailability and disposition kinetics of genistein in cats.

  2007cites this paper
• Pharmacokinetics of ceftriaxone after intravenous, intramuscular and subcutaneous administration to domestic cats.

  2007cites this paper
• Pharmacokinetics of levofloxacin after single intravenous and repeat oral administration to cats.

  2004cites this paper
• Pharmacokinetics of ciprofloxacin after single intravenous and repeat oral administration to cats.

  2004cites this paper