Kuru: memories of the NIH years

I was very pleased and honoured when John Collinge and Michael Alpers invited me to share personal recollections about research on kuru and related diseases during the more than 25 years I spent at the National Institutes of Health (NIH). Such reminiscences must be impossibly arbitrary and awkwardly

• Publication year

  2008

• Venue

  Philosophical Transactions of the Royal Society B: Biological Sciences

• Publication date

  2008-11-27

• Fields of study

  Biology, Medicine, History

• Identifiers
  DOI 10.1098/rstb.2008.4002PMID 18849246PMCID 2735519
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Early images of kuru and the people of Okapa

  2008cited by this paper
• Prions in the Food Chain

  2007cited by this paper
• Cells infected with scrapie and Creutzfeldt–Jakob disease agents produce intracellular 25-nm virus-like particles

  2007cited by this paper
• Reduction of transmissible spongiform encephalopathy infectivity from human red blood cells with prion protein affinity ligands

  2006cited by this paper
• Reduction in infectivity of endogenous transmissible spongiform encephalopathies present in blood by adsorption to selective affinity resins.

  2006cited by this paper
• Inactivation of the BSE agent by the heat and pressure process for manufacturing gelatine

  2005cited by this paper
• Effectiveness of leucoreduction for removal of infectivity of transmissible spongiform encephalopathies from blood.

  2004cited by this paper
• The transmissible spongiform encephalopathy agents: concerns and responses of United States regulatory agencies in maintaining the safety of biologics.

  1999cited by this paper
• Bovine sera used in the manufacture of biologicals: current concerns and policies of the U.S. Food and Drug Administration regarding the transmissible spongiform encephalopathies.

  1999cited by this paper
• The distribution of infectivity in blood components and plasma derivatives in experimental models of transmissible spongiform encephalopathy

  1998cited by this paper
• Prion diseases and the BSE crisis.

  1997cited by this paper
• Transmission of Creutzfeldt-Jakob disease to a chimpanzee by electrodes contaminated during neurosurgery.

  1994cited by this paper
• Human spongiform encephalopathy: The national institutes of health series of 300 cases of experimentally transmitted disease

  1994cited by this paper
• [Jakob-Creutzfeldt disease].

  1994cited by this paper
• Creutzfeldt-Jakob disease infectivity of growth hormone derived from human pituitary glands.

  1993cited by this paper
• Estimation of scrapie nucleic acid MW from standard curves for virus sensitivity to ionizing radiation

  1986cited by this paper
• Diagnosis of Creutzfeldt-Jakob disease by Western blot identification of marker protein in human brain tissue.

  1986cited by this paper
• Virus like sensitivity of the scrapie agent to heat inactivation.

  1984cited by this paper
• Scrapie infectious agent is virus-like in size and susceptibility to inactivation

  1984cited by this paper
• Creutzfeldt-Jakob disease in mice: persistent viremia and preferential replication of virus in low-density lymphocytes

  1983cited by this paper
• Novel proteinaceous infectious particles cause scrapie.

  1982cited by this paper
• Identification of a protein that purifies with the scrapie prion.

  1982cited by this paper
• Kuru: Early Letters and Field-Notes From the Collection of D. Carleton Gajdusek

  1981influential reference
• Creutzfeldt-Jakob disease virus isolations from the Gerstmann-Sträussler syndrome with an analysis of the various forms of amyloid plaque deposition in the virus-induced spongiform encephalopathies.

  1981cited by this paper
• Search for the cause of multiple sclerosis and other chronic diseases of the central nervous system

  1980cited by this paper
• Attempts to Establish Cell Cultures Infected with the Viruses of Subacute Spongiform Encephalopathies 1

  1980cited by this paper
• Slow transmissible diseases of the nervous system

  1979cited by this paper
• Unconventional viruses and the origin and disappearance of kuru.

  1977cited by this paper
• Danger of accidental person-to-person transmission of Creutzfeldt-Jakob disease by surgery.

  1977cited by this paper
• Experimental kuru in the spider monkey. Histopathological and ultrastructural studies of the brain during early stages of incubation.

  1975cited by this paper
• Letter: Possible person-to-person transmission of Creutzfeldt-Jakob disease.

  1974cited by this paper
• Letter: Hepatitis with hindsight.

  1974cited by this paper
• Letter: Hepatitis with hindsight.

  1974cited by this paper
• Inactivation of the Scrapie Agent by Near Monochromatic Ultraviolet Light

  1970cited by this paper
• Neuropathological comparisons of experimental kuru in chimpanzees with human kuru.

  1969cited by this paper
• Infection as the Etiology of Spongiform Encephalopathy (Creutzfeldt-Jakob Disease)

  1969cited by this paper
• Scrapie in Mice

  1968cited by this paper
• Creutzfeldt-Jakob Disease (Spongiform Encephalopathy): Transmission to the Chimpanzee

  1968cited by this paper
• Transmission of Experimental Kuru to the Spider Monkey (Ateles geoffreyi)

  1968cited by this paper
• Self-replication and scrapie.

  1967cited by this paper
• The Neurological Information Network of the National Institute of Neurological Diseases and Blindness

  1967cited by this paper
• Nature of the Scrapie Agent: Self-replication and Scrapie

  1967cited by this paper
• Slow, Latent, and Temperate Virus Infections

  1967cited by this paper
• SLOW, LATENT, AND TEMPERATE VIRUS INFECTIONS. NINDB MONOGRAPH No. 2

  1967cited by this paper
• The possible nature of the transmissible agent of scrapie

  1967cited by this paper
• Experimental Transmission of a Kuru-like Syndrome to Chimpanzees

  1966cited by this paper
• Experimental "kuru" in chimpanzees. A pathological report.

  1966cited by this paper
• The exceptionally small size of the scrapie agent.

  1966cited by this paper
• Dialysis of the Scrapie Agent

  1964cited by this paper
• DEGENERATION OF THE CEREBELLAR AND HYPOTHALAMONEUROHYPOPHYSIAL SYSTEMS IN SHEEP WITH SCRAPIE; AND ITS RELATIONSHIP TO HUMAN SYSTEM DEGENERATIONS.

  1964cited by this paper
• Scrapie and Kuru.

  1960cited by this paper
• Subacute spongiform encephalopathy--a subacute form of encephalopathy attributable to vascular dysfunction (spongiform cerebral atrophy).

  1960influential reference
• Pathology of Kuru.

  1959cited by this paper
• KURU: CLINICAL STUDY OF A NEW SYNDROME RESEMBLING PARALYSIS AGITANS IN NATIVES OF THE EASTERN HIGHLANDS OF AUSTRALIAN NEW GUINEA

  1957cited by this paper
• Degenerative disease of the central nervous system in New Guinea; the endemic occurrence of kuru in the native population.

  1957cited by this paper
• A case of mesenteric vascular occlusion.

  1949cited by this paper
• Die Entwicklung der serologisch-bakteriologisch-chemischen Abteilung der Staatskrankenanstalt Friedrichsberg

  1930cited by this paper
• Klinische und genealogische Beobachtungen bei einem Fall von spastischer Pseudosklerose Jakobs

  1930cited by this paper
• Zwei eigenartige Erkrankungen des Zentralnervensystems nach Art der spastischen Pseudosklerose (Jakob)

  1924cited by this paper

• Kuru Disease: Bridging the Gap Between Prion Biology and Human Health

  2024cites this paper
• Cannibals, slow viruses, Nobel Prize and young lads: the story of Daniel Carleton Gajdusek (1923-2008), laureate of the Nobel Prize in Physiology or Medicine (1976) and honorary doctor of Comenius University in Bratislava (1996)

  2024cites this paper
• Analysis of non-human primate models for evaluating prion disease therapeutic efficacy

  2022cites this paper
• From Kuru to Alzheimer: A personal outlook

  2021cites this paper
• Kuru, the First Human Prion Disease

  2019cites this paper
• Human transmissible spongiform encephalopathies: historic view.

  2018cites this paper
• Gehen Sie dem Humor auf den Grund

  2018cites this paper
• Prion Diseases

  2017cites this paper
• Kuru: Introduction to Prion Diseases

  2017cites this paper
• Human prion diseases: surgical lessons learned from iatrogenic prion transmission.

  2016cites this paper
• History of Prions and transmission of protein misfolding.

  2015cites this paper
• Prions et transconformation protéique: une perspective historique

  2015cites this paper
• Kuru: A Journey Back in Time from Papua New Guinea to the Neanderthals’ Extinction

  2013cites this paper
• Kuru, the first prion disease: a travel back in time from Papua New Guinea to Neanderthals extinction

  2013cites this paper
• Transmissible Spongiform Encephalopathies

  2011cites this paper
• Kuru and D. Carleton Gajdusek: a close encounter.

  2009cites this paper
• Some tributes to research colleagues and other contributors to our knowledge about kuru

  2008cites this paper
• Introduction

  2008cites this paper