SYK (spleen tyrosine kinase)

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Atlas of genetics and cytogenetics in oncology and haematology

• Publication date

  2018-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.4267/2042/66934
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer.

  2015cited by this paper
• Therapeutic Potential of Spleen Tyrosine Kinase Inhibition for Treating High-Risk Precursor B Cell Acute Lymphoblastic Leukemia

  2014cited by this paper
• Inhibition of spleen tyrosine kinase in the treatment of rheumatoid arthritis.

  2013cited by this paper
• Alternative splicing of SYK regulates mitosis and cell survival

  2011cited by this paper
• SYK inhibition and response prediction in diffuse large B-cell lymphoma.

  2011cited by this paper
• Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases

  2010cited by this paper
• The SYK tyrosine kinase: a crucial player in diverse biological functions

  2010cited by this paper
• Novel insights into the mechanism of decreased expression of type X collagen in human mesenchymal stem cells from patients with osteoarthritis cultured on nitrogen-rich plasma polymers: implication of cyclooxygenase-1.

  2010cited by this paper
• Signalling through C-type lectin receptors: shaping immune responses

  2009cited by this paper
• The structure, regulation, and function of ZAP‐70

  2009cited by this paper
• Syk and pTyr'd: Signaling through the B cell antigen receptor.

  2009cited by this paper
• Redundant role for Zap70 in B cell development and activation

  2008cited by this paper
• The kinase Syk as an adaptor controlling sustained calcium signalling and B‐cell development

  2008cited by this paper
• Molecular Mechanism of the Syk Activation Switch*

  2008cited by this paper
• ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia.

  2008cited by this paper
• Syk inhibitors as treatment for allergic rhinitis.

  2008cited by this paper
• Distinct roles for Syk and ZAP-70 during early thymocyte development

  2007cited by this paper
• Structural basis for the inhibition of tyrosine kinase activity of ZAP-70.

  2007cited by this paper
• Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo

  2007cited by this paper
• Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma

  2006cited by this paper
• Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells.

  2006cited by this paper
• Genomic and expression profiling identifies the B‐cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma

  2006cited by this paper
• Syk-dependent mTOR activation in follicular lymphoma cells.

  2006cited by this paper
• Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy.

  2006cited by this paper
• Syk activation in dendritic cells is essential for airway hyperresponsiveness and inflammation.

  2006cited by this paper
• Intramolecular Regulatory Switch in ZAP-70: Analogy with Receptor Tyrosine Kinases

  2005cited by this paper
• Src and Syk kinases: key regulators of phagocytic cell activation.

  2005cited by this paper
• Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis.

  2005cited by this paper
• Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma.

  2004cited by this paper
• A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase*

  2004cited by this paper
• Receptor tyrosine kinases: Getting on TRK

  2004cited by this paper
• Targeting Syk as a treatment for allergic and autoimmune disorders

  2004cited by this paper
• Molecular cloning of the human homologue to the pig protein-tyrosine kinase syk

  2004cited by this paper
• Chromosomal location of the Syk and ZAP-70 tyrosine kinase genes in mice and humans

  2004cited by this paper
• Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer.

  2003cited by this paper
• Structure and function of Syk protein-tyrosine kinase.

  2001cited by this paper
• Specific immunoglobulin E responses in ZAP‐70‐deficient patients are mediated by Syk‐dependent T‐cell receptor signalling

  2001cited by this paper
• Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12).

  2001cited by this paper
• Hypermethylation leads to silencing of the SYK gene in human breast cancer.

  2001cited by this paper
• Visualization of Syk-Antigen Receptor Interactions Using Green Fluorescent Protein: Differential Roles for Syk and Lyn in the Regulation of Receptor Capping and Internalization1

  2001cited by this paper
• Ubiquitination and degradation of Syk and ZAP-70 protein tyrosine kinases in human NK cells upon CD16 engagement

  2001cited by this paper
• Syk expression and novel function in a wide variety of tissues.

  2001cited by this paper
• Purification of a 72-kDa protein-tyrosine kinase from rat liver and its identification as Syk: involvement of Syk in signaling events of hepatocytes.

  2000cited by this paper
• The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells

  2000cited by this paper
• Phosphorylation of Syk Activation Loop Tyrosines Is Essential for Syk Function

  2000cited by this paper
• Tyrosine kinase SYK: essential functions for immunoreceptor signalling.

  2000cited by this paper
• Syk: a new player in the field of breast cancer

  2000cited by this paper
• Identification of seven genes regulated by wild-type p53 in a colon cancer cell line carrying a well-controlled wild-type p53 expression system.

  1999cited by this paper
• Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide.

  1998cited by this paper
• syk protein tyrosine kinase regulates Fc receptor γ‐chain‐mediated transport to lysosomes

  1998cited by this paper
• A Critical Role for Syk in Signal Transduction and Phagocytosis Mediated by Fcγ Receptors on Macrophages

  1997cited by this paper
• Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

  1995cited by this paper
• Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase.

  1995cited by this paper
• Syk tyrosine kinase required for mouse viability and B-cell development

  1995cited by this paper
• Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

  1995cited by this paper
• Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.

  1995cited by this paper
• Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling

  1994cited by this paper
• Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.

  1994cited by this paper
• Activation of p56lck by p72syk through physical association and N-terminal tyrosine phosphorylation

  1994cited by this paper
• Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex.

  1994cited by this paper
• Association with B-cell-antigen receptor with protein-tyrosine kinase p72[syk] and activation by engagement of membrane IgM

  1994cited by this paper
• Association with B-cell-antigen receptor with protein-tyrosine kinase p72syk and activation by engagement of membrane IgM.

  1993cited by this paper
• CD22 associates with the human surface IgM-B-cell antigen receptor complex.

  1993cited by this paper
• T cell activation by clustered tyrosine kinases.

  1993cited by this paper
• ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain.

  1992cited by this paper
• Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor.

  1992cited by this paper
• Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis.

  1991cited by this paper
• Purification and characterization of a cytosolic protein-tyrosine kinase from porcine spleen

  1990cited by this paper

• No citing papers are available for this paper.