Factors underlying bursting behavior in a network of cultured hippocampal neurons exposed to zero magnesium.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Neurophysiology

• Publication date

  2004-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1152/JN.00547.2003PMID 14534286PMCID PMC2892720
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The epileptogenic effect of seizures induced by hypoxia: the role of NMDA and AMPA/KA antagonists.

  2003cited by this paper
• Presynaptic calcium influx, neurotransmitter release, and neuromuscular disease.

  2002cited by this paper
• Persistent epileptiform activity induced by low Mg2+ in intact immature brain structures

  2002cited by this paper
• Release Dependence to a Paired Stimulus at a Synaptic Release Site with a Small Variable Pool of Immediately Releasable Vesicles

  2002cited by this paper
• Comparison of spontaneous and evoked epileptiform activity in three in vitro epilepsy models.

  2002cited by this paper
• Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons.

  2001cited by this paper
• Ryanodine Sensitizes the Ca2+ Release Channel (Ryanodine Receptor) to Ca2+ Activation*

  2001cited by this paper
• Neuronal activity and the establishment of normal and epileptic circuits during brain development.

  2001cited by this paper
• Ryanodine sensitizes the Ca(2+) release channel (ryanodine receptor) to Ca(2+) activation.

  2001cited by this paper
• Statistical model relating CA3 burst probability to recovery from burst-induced depression at recurrent collateral synapses.

  2001cited by this paper
• Modulation of spontaneous quantal release of neurotransmitters in the hippocampus.

  2001cited by this paper
• Coupling of agonist‐induced AMPA receptor internalization with receptor recycling

  2001cited by this paper
• Activation of Silent Synapses by Rapid Activity-Dependent Synaptic Recruitment of AMPA Receptors

  2001cited by this paper
• Fluorescent tracer in pilocarpine‐treated rats shows widespread aberrant hippocampal neuronal connectivity

  2001cited by this paper
• Restless AMPA receptors: implications for synaptic transmission and plasticity.

  2001cited by this paper
• LTP gets culture.

  2001cited by this paper
• Prolonged bursts occur in normal calcium in hippocampal slices after raising excitability and blocking synaptic transmission.

  2001cited by this paper
• Recurrent excitatory connectivity in the dentate gyrus of kindled and kainic acid-treated rats.

  2000cited by this paper
• Cellular abnormalities and synaptic plasticity in seizure disorders of the immature nervous system.

  2000cited by this paper
• Distinct Roles for Ionotropic and Metabotropic Glutamate Receptors in the Maturation of Excitatory Synapses

  2000cited by this paper
• Identification of a novel process limiting the rate of synaptic vesicle cycling at hippocampal synapses.

  1999cited by this paper
• Role of AMPA receptor cycling in synaptic transmission and plasticity.

  1999cited by this paper
• Reciprocal interactions between CA3 network activity and strength of recurrent collateral synapses

  1999cited by this paper
• Up‐regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal lobe epilepsy

  1999cited by this paper
• Monitoring secretory membrane with FM1-43 fluorescence.

  1999cited by this paper
• Mechanisms of neuronal synchronization during epileptiform activity.

  1999cited by this paper
• On the quantal mechanism of neural transmitter release

  1999cited by this paper
• Epileptiform activity induced by low Mg2+ in cultured rat hippocampal slices.

  1999cited by this paper
• Heterogeneity in the Molecular Composition of Excitatory Postsynaptic Sites during Development of Hippocampal Neurons in Culture

  1998cited by this paper
• Presynaptic modulation of CA3 network activity

  1998cited by this paper
• Prolonged activation of the N-methyl-D-aspartate receptor-Ca2+ transduction pathway causes spontaneous recurrent epileptiform discharges in hippocampal neurons in culture.

  1998cited by this paper
• Ontogeny of altered synaptic function in a rat model of chronic temporal lobe epilepsy.

  1998influential reference
• Culturing nerve cells

  1998cited by this paper
• Spatiotemporal distribution of intracellular calcium transients during epileptiform activity in guinea pig hippocampal slices.

  1997cited by this paper
• Activity regulates the synaptic localization of the NMDA receptor in hippocampal neurons.

  1997cited by this paper
• Heterogeneity of release probability, facilitation, and depletion at central synapses.

  1997cited by this paper
• Profound disturbances of pre- and postsynaptic GABAB-receptor-mediated processes in region CA1 in a chronic model of temporal lobe epilepsy.

  1996influential reference
• NMDA Receptor Dependence of Kindling and Mossy Fiber Sprouting: Evidence that the NMDA Receptor Regulates Patterning of Hippocampal Circuits in the Adult Brain

  1996cited by this paper
• Calcium-Dependent Paired-Pulse Facilitation of Miniature EPSC Frequency Accompanies Depression of EPSCs at Hippocampal Synapses in Culture

  1996cited by this paper
• Electrographic Seizures and New Recurrent Excitatory Circuits in the Dentate Gyrus of Hippocampal Slices from Kainate-Treated Epileptic Rats

  1996cited by this paper
• Extracellular Mg2+ modulates intracellular Ca2+ in acutely isolated hippocampal CA1 pyramidal cells of the guinea-pig.

  1996cited by this paper
• Recurrent spontaneous seizure activity in hippocampal neuronal networks in culture.

  1995cited by this paper
• Cellular mechanisms of 4‐aminopyridine‐induced synchronized after‐discharges in the rat hippocampal slice.

  1995cited by this paper
• Regional heterogeneity of pathophysiological alterations in CA1 and dentate gyrus in a chronic model of temporal lobe epilepsy.

  1995cited by this paper
• Properties of inhibitory and excitatory synapses between hippocampal neurons in very low density cultures

  1994cited by this paper
• Dendritic attenuation of synaptic potentials and currents: the role of passive membrane properties.

  1994influential reference
• Glutamate receptor update.

  1994cited by this paper
• Phorbol esters enhance synaptic transmission by a presynaptic, calcium‐dependent mechanism in rat hippocampus.

  1993cited by this paper
• Perforated patch-clamp analysis of the passive membrane properties of three classes of hippocampal neurons.

  1992influential reference
• Electrophysiology of glutamate neurotoxicity in vitro: induction of a calcium-dependent extended neuronal depolarization.

  1992influential reference
• The distribution of synapsin I and synaptophysin in hippocampal neurons developing in culture

  1991cited by this paper
• 5. Seizure-like activity in cell culture

  1991cited by this paper
• A model of a CA3 hippocampal pyramidal neuron incorporating voltage-clamp data on intrinsic conductances.

  1991cited by this paper
• Seizure-like activity in cell culture.

  1991cited by this paper
• Epileptiform activity in microcultures containing small numbers of hippocampal neurons.

  1990cited by this paper
• Excitatory amino acid receptors in epilepsy.

  1990influential reference
• Low magnesium epileptogenesis in the rat hippocampal slice: electrophysiological and pharmacological features.

  1990cited by this paper
• NMDA and non-NMDA receptors are co-localized at individual excitatory synapses in cultured rat hippocampus

  1989cited by this paper
• N‐methyl‐D‐aspartate‐activated channels of mouse central neurones in magnesium‐free solutions.

  1988cited by this paper
• Low-magnesium epilepsy in rat hippocampal slices: inhibitory postsynaptic potentials in the CA1 subfield.

  1988cited by this paper
• An N-methyl-D-aspartate receptor-independent excitatory action of partial reduction of extracellular [Mg2+] in CA1-region of rat hippocampal slices.

  1987cited by this paper
• Seizure-like discharges induced by lowering [Mg2+]o in the human epileptogenic neocortex maintained in vitro.

  1987cited by this paper
• Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices.

  1987cited by this paper
• Characterization of an N-methyl-D-aspartate receptor component of synaptic transmission in rat hippocampal slices.

  1987cited by this paper
• Models of the cellular mechanism underlying propagation of epileptiform activity in the CA2-CA3 region of the hippocampal slice.

  1987cited by this paper
• Epileptiform activity in combined slices of the hippocampus, subiculum and entorhinal cortex during perfusion with low magnesium medium.

  1986cited by this paper
• N-methyl-D-aspartate receptor antagonists reduce synaptic excitation in the hippocampus

  1986cited by this paper
• Magnesium-free medium activates seizure-like events in the rat hippocampal slice.

  1986cited by this paper
• GABAergic neurons in rat hippocampal culture.

  1986cited by this paper
• Magnesium ions block an N-methyl-D-aspartate receptor-mediated component of synaptic transmission in rat hippocampus.

  1985cited by this paper
• Mixed‐agonist action of excitatory amino acids on mouse spinal cord neurones under voltage clamp.

  1984cited by this paper
• Picrotoxin-induced epileptiform activity in hippocampus: role of endogenous versus synaptic factors.

  1984influential reference
• Synchronized afterdischarges in the hippocampus: simulation studies of the cellular mechanism.

  1984cited by this paper
• Synchronized burst discharge in disinhibited hippocampal slice. II. Model of cellular mechanism.

  1983cited by this paper
• Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

  1983cited by this paper
• Synchronized burst discharge in disinhibited hippocampal slice. II. Model of cellular mechanism.

  1983cited by this paper
• A neurotrophic factor (NTF) released from primary glial cultures supports survival and fiber outgrowth of cultured hippocampal neurons

  1982cited by this paper
• The adsorption of divalent cations to phosphatidylcholine bilayer membranes.

  1978cited by this paper
• Preliminary report on the magnesium deficient rat as a model of epilepsy.

  1978cited by this paper
• Preliminary report on the magnesium deficient rat as a model of epilepsy.

  1978cited by this paper
• Cellular and field potential properties of epileptogenic hippocampal slices.

  1978cited by this paper
• Rat hippocampal neurons in dispersed cell culture.

  1977cited by this paper
• The electrostatic basis of Mg++ inhibition of transmitter release.

  1974cited by this paper
• Divalent Ions and the Surface Potential of Charged Phospholipid Membranes

  1971cited by this paper
• Quantal mechanism of neural transmitter release.

  1971cited by this paper
• Co‐operative action of calcium ions in transmitter release at the neuromuscular junction

  1967cited by this paper
• The action of calcium on the electrical properties of squid axons

  1957cited by this paper

• BETMB: A Dual‐Target Compound for Synergistic Suppression of Neuronal Hyperexcitability in Refractory Epilepsy via Concurrent Modulation of Nav Channels and GABAA Receptors

  2026cites this paper
• Effect of acute elevated magnesium on bursting activity and information-processing dynamics in cortical cultures

  2025cites this paper
• Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome

  2025cites this paper
• Comparative Study on Modulation of Synchronized Neuronal Activity by SK Channels and Na/K-ATPase

  2025cites this paper
• Tanshinone IIA Regulates Synaptic Plasticity in Mg2+-Free-Induced Epileptic Hippocampal Neurons via the PI3K/Akt Signaling Pathway.

  2024cites this paper
• Exploring the Role of TRP Channels and Neurotrophic Factors in Epileptogenesis: Insights from Diverse Seizure Models

  2024cites this paper
• Intrahippocampal Supramolecular Assemblies Directed Bioorthogonal Liberation of Neurotransmitters to Suppress Seizures in Freely Moving Mice

  2024cites this paper
• (R,S)-trihexyphenidyl, acting via a muscarinic receptor-independent mechanism, inhibits hippocampal glutamatergic and GABAergic synaptic transmissions: Potential relevance for treatment of organophosphorus intoxication.

  2023cites this paper
• Rescue of sharp wave-ripples and prevention of network hyperexcitability in the ventral but not the dorsal hippocampus of a rat model of fragile X syndrome

  2023cites this paper
• A modular microfluidic platform to enable complex and customisable in vitro models for neuroscience.

  2022cites this paper
• Synedrella nodiflora Extract Depresses Excitatory Synaptic Transmission and Chemically-Induced In Vitro Seizures in the Rat Hippocampus

  2021cites this paper
• Transient incubation of cultured hippocampal neurons in the absence of magnesium induces rhythmic and synchronized epileptiform-like activity

  2021cites this paper
• A critical period for learning and plastic changes at hippocampal CA1 synapses

  2021cites this paper
• NMDAR plasticity and metaplasticity in early odor preference learning in rats

  2019cites this paper
• Autaptic cultures of human induced neurons as a versatile platform for studying synaptic function and neuronal morphology

  2019cites this paper
• Distinct Regulation of Bioenergetics and Translation by Group I mGluR and NMDAR

  2019cites this paper
• Progesterone receptor activation regulates seizure susceptibility

  2019cites this paper
• Role of gap junction protein 36 in pentetrazole-induced acute epilepsy in rats

  2018cites this paper
• Berberine exerts antioxidant effects via protection of spiral ganglion cells against cytomegalovirus‐induced apoptosis

  2018cites this paper
• Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels

  2017cites this paper
• BDNF / NT 3 Regulate AIS Location and Affect Neuronal Excitability in Cultured Hippocampal Neurons

  2017cites this paper
• Brain‐derived neurotrophic factor/neurotrophin 3 regulate axon initial segment location and affect neuronal excitability in cultured hippocampal neurons

  2017cites this paper
• Oscillatory and epileptiform activity in human and rodent cortical regions in vitro

  2017cites this paper
• A 340/380 nm light‐emitting diode illuminator for Fura‐2 AM ratiometric Ca2+ imaging of live cells with better than 5 nM precision

  2017influential citation
• NMDA receptors in mouse anterior piriform cortex initialize early odor preference learning and L-type calcium channels engage for long-term memory

  2016cites this paper
• Creatine Enhances Transdifferentiation of Bone Marrow Stromal Cell-Derived Neural Stem Cell Into GABAergic Neuron-Like Cells Characterized With Differential Gene Expression

  2016cites this paper
• EGAR, A Food Protein-Derived Tetrapeptide, Reduces Seizure Activity in Pentylenetetrazole-Induced Epilepsy Models Through α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate Receptors

  2016cites this paper
• Hippocampus and epilepsy: Findings from human tissues.

  2015cites this paper
• Sustained Firing at Low Rates Dynamics of Excitatory Synaptic Components in

  2015cites this paper
• Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activity

  2015cites this paper
• Synchronization of action potentials during low-magnesium-induced bursting.

  2015influential citation
• Microelectrode Arrays for Neuronal Recordings: Developing Novel Technology and Applications

  2015cites this paper
• Cholinergic differentiation of neural stem cells generated from cell aggregates-derived from Human Bone marrow stromal cells

  2015cites this paper
• Increased excitability and excitatory synaptic transmission during in vitro ischemia in the neonatal mouse hippocampus.

  2015cites this paper
• Effects of carbon nanotube and conducting polymer coated microelectrodes on single-unit recordings in vitro

  2014cites this paper
• MiR-134 blockade prevents status epilepticus like-activity and is neuroprotective in cultured hippocampal neurons.

  2014cites this paper
• Anti-Epileptic Effect of Ganoderma Lucidum Polysaccharides by Inhibition of Intracellular Calcium Accumulation and Stimulation of Expression of CaMKII α in Epileptic Hippocampal Neurons

  2014cites this paper
• Curcumol from Rhizoma Curcumae suppresses epileptic seizure by facilitation of GABA(A) receptors.

  2014cites this paper
• ANTIEPILEPTIC DRUGS INCREASE THE RATIO OF ACKGROUND SYNAPTIC INHIBITION TO EXCITATION AND ECREASE NEURONAL EXCITABILITY IN NEURONES OF HE RAT ENTORHINAL CORTEX IN VITRO

  2014cites this paper
• Seizure activity results in calcium- and mitochondria-independent ROS production via NADPH and xanthine oxidase activation

  2014cites this paper
• New In Vitro Phenotypic Assay for Epilepsy: Fluorescent Measurement of Synchronized Neuronal Calcium Oscillations

  2014cites this paper
• Developmental and maintenance defects in Rett syndrome neurons identified by a new mouse staging system in vitro

  2013cites this paper
• Analysis of Glutamatergic and Gabaergic Receptor Dynamics in Coupled Oscillator Neural Model

  2013cites this paper
• α-asarone from Acorus gramineus alleviates epilepsy by modulating A-type GABA receptors.

  2013cites this paper
• Neuroprotective effects of ganoderic acid extract against epilepsy in primary hippocampal neurons.

  2013cites this paper
• Endogenous cholinergic tone modulates spontaneous network level neuronal activity in primary cortical cultures grown on multi-electrode arrays

  2013cites this paper
• M Current-Based Therapies for Nerve Agent Seizures

  2012cites this paper
• Saikosaponin a Mediates the Anticonvulsant Properties in the HNC Models of AE and SE by Inhibiting NMDA Receptor Current and Persistent Sodium Current

  2012influential citation
• Characterization of status epilepticus induced by two organophosphates in rats.

  2012cites this paper
• Calcium‐permeable AMPA receptors are expressed in a rodent model of status epilepticus

  2012cites this paper
• Development of GABAergic Synapses in Cultured Hippocampal Neurons

  2011cites this paper
• A synaptic strategy for consolidation of convergent visuotopic maps.

  2011cites this paper
• Homeostatic Strengthening of Inhibitory Synapses Is Mediated by the Accumulation of GABAA Receptors

  2011cites this paper
• Prolonged seizure activity impairs mitochondrial bioenergetics and induces cell death

  2011cites this paper
• Central cholinesterase inhibition enhances glutamatergic synaptic transmission.

  2010cites this paper
• Chronic in vitro ketosis is neuroprotective but not anti‐convulsant

  2010cites this paper
• Diverse antiepileptic drugs increase the ratio of background synaptic inhibition to excitation and decrease neuronal excitability in neurones of the rat entorhinal cortex in vitro

  2010cites this paper
• Encoding of Spatio-Temporal Input Characteristics by a CA1 Pyramidal Neuron Model

  2010cites this paper
• Decoding glutamate receptor activation by the Ca2+ sensor protein hippocalcin in rat hippocampal neurons

  2010cites this paper
• Calcium control of gene regulation in rat hippocampal neuronal cultures

  2009cites this paper
• The glycine transport inhibitor sarcosine is an NMDA receptor co‐agonist that differs from glycine

  2009influential citation
• Nitric oxide alters GABAergic synaptic transmission in cultured hippocampal neurons.

  2009cites this paper
• Personal Data

  2009cites this paper
• Slow intracellular accumulation of GABA(A) receptor delta subunit is modulated by brain-derived neurotrophic factor.

  2009cites this paper
• Standard antiepileptic drugs fail to block epileptiform activity in rat organotypic hippocampal slice cultures

  2008cites this paper
• The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons.

  2008cites this paper
• A combination of ketamine and diazepam synergistically controls refractory status epilepticus induced by cholinergic stimulation

  2008cites this paper
• Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents.

  2008cites this paper
• Subunit-Specific Trafficking of GABAA Receptors during Status Epilepticus

  2008cites this paper
• A Model for Population Firing in Neuronal Networks with Planar Lattice Topology

  2008influential citation
• A-Type GABA Receptor as a Central Target of TRPM8 Agonist Menthol

  2008cites this paper
• Spontaneous neuronal burst discharges as dependent and independent variables in the maturation of cerebral cortex tissue cultured in vitro: a review of activity-dependent studies in live 'model' systems for the development of intrinsically generated bioelectric slow-wave sleep patterns.

  2008cites this paper
• [Epileptiform activities generated in vitro by human temporal lobe tissue].

  2008cites this paper
• Physiological consequences of selective suppression of synaptic transmission in developing cerebral cortical networks in vitro: differential effects on intrinsically generated bioelectric discharges in a living 'model' system for slow-wave sleep activity.

  2008cites this paper
• Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: role of NMDA receptor activation and NMDA dependent calcium entry.

  2008influential citation
• Activités épileptiques produites in vitro par le tissu temporal humain

  2008cites this paper
• Hydroxyamide Analogs of Propofol Exhibit State-Dependent Block of Sodium Channels in Hippocampal Neurons: Implications for Anticonvulsant Activity

  2007cites this paper
• Zinc enhances the inhibitory effects of strychnine-sensitive glycine receptors in mouse hippocampal neurons.

  2007influential citation
• GABAA Receptor Internalization during Seizures

  2007cites this paper
• In vitro status epilepticus but not spontaneous recurrent seizures cause cell death in cultured hippocampal neurons.

  2007influential citation
• Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus.

  2007cites this paper
• Network activity-independent coordinated gene expression program for synapse assembly

  2007cites this paper
• Endocannabinoids block status epilepticus in cultured hippocampal neurons.

  2007influential citation
• Methodological approaches to exploring epileptic disorders in the human brain in vitro.

  2006cites this paper
• Development of gamma-aminobutyric acidergic synapses in cultured hippocampal neurons.

  2006cites this paper
• Activity-dependent scaling of GABAergic synapse strength is regulated by brain-derived neurotrophic factor.

  2006influential citation
• Development of γ‐aminobutyric acidergic synapses in cultured hippocampal neurons

  2006cites this paper
• Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus

  2006cites this paper
• Dynamics of excitatory synaptic components in sustained firing at low rates.

  2005cites this paper
• Selective enhancement of tonic inhibition by increasing ambient GABA is insufficient to suppress excitotoxicity in hippocampal neurons.

  2005cites this paper
• Cultured Hippocampal Pyramidal Neurons Express Two Kinds of GABAA Receptors

  2005cites this paper
• Greater contribution of N-methyl-D-aspartic acid receptors in ventral compared to dorsal hippocampal slices in the expression and long-term maintenance of epileptiform activity.

  2005cites this paper
• Status Epilepticus Increases the Intracellular Accumulation of GABAA Receptors

  2005influential citation
• Synaptic and extrasynaptic localization of brain‐derived neurotrophic factor and the tyrosine kinase B receptor in cultured hippocampal neurons

  2004cites this paper
• A comparison of three NMDA receptor antagonists in the treatment of prolonged status epilepticus.

  2004cites this paper
• Central Cholinesterase Inhibition Enhances Glutamatergic Synaptic Transmission Slice Preparation

  year unknowncites this paper
• Effects of Ganoderma Acid Extract on the SOD and Mitochondrion in Zero-Mg 2+ Induced Epileptic Hippocampal Neurons

  year unknowncites this paper