Mutational analysis of the U12-dependent branch site consensus sequence.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  RNA: A publication of the RNA Society

• Publication date

  2008-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1261/rna.1189008PMID 18824513PMCID PMC2578861
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Alternative modes of binding by U2AF65 at the polypyrimidine tract.

  2008cited by this paper
• Human branch point consensus sequence is yUnAy

  2008cited by this paper
• RS domain–splicing signal interactions in splicing of U12-type and U2-type introns

  2007cited by this paper
• Alternative splicing and bioinformatic analysis of human U12-type introns

  2007cited by this paper
• 13 Spliceosome Structure and Function

  2006cited by this paper
• An LKB1 AT-AC intron mutation causes Peutz-Jeghers syndrome via splicing at noncanonical cryptic splice sites

  2005cited by this paper
• Splicing of a rare class of introns by the U12-dependent spliceosome

  2005cited by this paper
• A mutational analysis of U12-dependent splice site dinucleotides.

  2005cited by this paper
• An Intronic Enhancer Regulates Splicing of the Twintron of Drosophila melanogaster prospero Pre-mRNA by Two Different Spliceosomes

  2004cited by this paper
• A pathway of sequential arginine-serine-rich domain-splicing signal interactions during mammalian spliceosome assembly.

  2004cited by this paper
• Branchpoint selection in the splicing of U12-dependent introns in vitro.

  2002cited by this paper
• Role of the 3′ Splice Site in U12-Dependent Intron Splicing

  2001cited by this paper
• Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway.

  2001cited by this paper
• A computational scan for U12-dependent introns in the human genome sequence.

  2001cited by this paper
• Dual Function for U2AF35 in AG-Dependent Pre-mRNA Splicing

  2001cited by this paper
• Alternative splicing of U12-dependent introns in vivo responds to purine-rich enhancers.

  2001cited by this paper
• Initial recognition of U12-dependent introns requires both U11/5' splice-site and U12/branchpoint interactions.

  1999cited by this paper
• Evidence for Substrate-Specific Requirement of the Splicing Factor U2AF35 and for Its Function after Polypyrimidine Tract Recognition by U2AF65

  1999cited by this paper
• Genomic-scale quantitative analysis of yeast pre-mRNA splicing: implications for splice-site recognition.

  1999cited by this paper
• Functional recognition of the 3′ splice site AG by the splicing factor U2AF35

  1999cited by this paper
• Both subunits of U2AF recognize the 3′ splice site in Caenorhabditis elegans

  1999cited by this paper
• Evolutionary fates and origins of U12-type introns.

  1998cited by this paper
• RNA-RNA Interactions in Nuclear Pre-mRNA Splicing

  1998cited by this paper
• Base pairing with U6atac snRNA is required for 5' splice site activation of U12-dependent introns in vivo.

  1998cited by this paper
• A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition.

  1998cited by this paper
• U11 snRNA interacts in vivo with the 5' splice site of U12-dependent (AU-AC) pre-mRNA introns.

  1997cited by this paper
• The splicing factor BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC.

  1997cited by this paper
• Terminal intron dinucleotide sequences do not distinguish between U2- and U12-dependent introns.

  1997cited by this paper
• Interaction of U2AF65 RS region with pre-mRNA branch point and promotion of base pairing with U2 snRNA [corrected].

  1996cited by this paper
• A novel spliceosome containing U11, U12, and U5 snRNPs excises a minor class (AT-AC) intron in vitro.

  1996cited by this paper
• The structure and function of proteins involved in mammalian pre-mRNA splicing.

  1996cited by this paper
• Requirement of U12 snRNA for in Vivo Splicing of a Minor Class of Eukaryotic Nuclear Pre-mRNA Introns

  1996cited by this paper
• U1-Mediated Exon Definition Interactions Between AT-AC and GT-AG Introns

  1996cited by this paper
• The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing.

  1996cited by this paper
• Interaction of U2AF65 RS Region with Pre-mRNA of Branch Point and Promotion Base Pairing with U2 snRNA

  1996cited by this paper
• Sequential recognition of the pre-mRNA branch point by U2AF65 and a novel spliceosome-associated 28-kDa protein.

  1995cited by this paper
• Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity.

  1995cited by this paper
• Predicting thermodynamic properties of RNA.

  1995cited by this paper
• Branch nucleophile selection in pre-mRNA splicing: evidence for the bulged duplex model.

  1994cited by this paper
• The yeast MUD2 protein: an interaction with PRP11 defines a bridge between commitment complexes and U2 snRNP addition.

  1994cited by this paper
• A Mutational Analysis of the Polypyrimidine Tract of Introns

  1993cited by this paper
• A mutational analysis of the polypyrimidine tract of introns. Effects of sequence differences in pyrimidine tracts on splicing.

  1993cited by this paper
• Splicing of precursors to mRNAs by the spliceosomes

  1993cited by this paper
• The low-abundance U11 and U12 small nuclear ribonucleoproteins (snRNPs) interact to form a two-snRNP complex

  1992cited by this paper
• Control of alternative splicing by the differential binding of U1 small nuclear ribonucleoprotein particle.

  1991cited by this paper
• Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing.

  1989cited by this paper
• UACUAAC is the preferred branch site for mammalian mRNA splicing.

  1989cited by this paper
• A compensatory base change in human U2 snRNA can suppress a branch site mutation.

  1989cited by this paper
• Alternative splicing of SV40 early pre-mRNA is determined by branch site selection.

  1988cited by this paper
• A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly.

  1988cited by this paper
• Cryptic branch point activation allows accurate in vitro splicing of human beta-globin intron mutants.

  1985cited by this paper
• Nonconsensus branch-site sequences in the in vitro splicing of transcripts of mutant rabbit beta-globin genes.

  1985cited by this paper

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  2022cites this paper
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  2021cites this paper
• Investigation into the molecular mechanisms of congenital insensitivity to pain

  2018cites this paper
• U6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III

  2016cites this paper
• Structural and mechanistic insights into human splicing factor SF3b complex derived using an integrated approach guided by the cryo-EM density maps

  2016cites this paper
• RNA-Protein Interactions in the U12-Dependent Spliceosome

  2016cites this paper
• THE REGULATION OF U 12-DEPENDENT SPLICING AND ITS SIGNIFICANCE TO mRNA STABILITY

  2014cites this paper
• Nova Mediates Experience Dependent Processing of Orb2A mRNA

  2013cites this paper
• The significant other: splicing by the minor spliceosome

  2012cites this paper
• The function and regulation of the U11-48K protein in U12-dependent splicing

  2012cites this paper
• Functionally important structural elements of U12 snRNA

  2011cites this paper
• A Contracted DNA Repeat in LHX3 Intron 5 Is Associated with Aberrant Splicing and Pituitary Dwarfism in German Shepherd Dogs

  2011cites this paper
• U12-type Spliceosome : Localization and Effects of Splicing Efficiency on Gene Expression

  2010cites this paper