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Epigenetic Modification of Nociceptive Media- tors: Implications for the Etiology of Neural Hy- persensitivity (Part I)

Mary K. Pathak,Lei Liming,Nan Wang,M. Bolick,Wei Wang,S. Feng,Aili Sunny,Xian Wang,Xiaofeng Shen,Shiqin Xu,Fuzhou Wang

Published 2015 in Unknown venue

ABSTRACT

SUMMARY Many factors have been identified contributing to the pathogenesis of pain, whereas we still cannot conquer the pain based on these findings suggesting that further studies are needed and other more potent mediators should be investigated. Epigenetics, in contrast to genetics, refers to the functionally relevant modifications to the genome that do not cause changes in underlying DNA sequence. These kinds of changes in gene expression or cellular phenotype regarded as landmarks of epigenetics are regulated by different types of modifications including gene methylation, histone acetylation, phosphorylation, imprinting and reprogramming etc. We, in this part (Part I), will review the general epigenetic modifications on molecular mediators on biological processes as the preface of the second part of the whole article (Part II will be available in the June issue of the journal). This general understanding of the epigenetic

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