T Cell Aging: A Review of the Transcriptional Changes Determined from Genome-Wide Analysis

Age carries a detrimental impact on T cell function. In the past decade, analyses of the genome-scale transcriptional changes of T cells during aging have yielded a large amount of data and provided a global view of gene expression changes in T cells from aged hosts as well as subsets of T cells accumulated with age. Here, we aim to review the changes of gene expression in thymocytes and peripheral mature T cells, as well as the subsets of T cells accumulated with age, and discuss the gene networks and signaling pathways that are altered with aging in T cells. We also discuss future direction for furthering the understanding of the molecular basis of gene expression alterations in aged T cells, which could potentially provide opportunities for gene-based clinical interventions.

• Publication year

  2013

• Venue

  Frontiers in Immunology

• Publication date

  2013-05-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3389/fimmu.2013.00121PMID 23730304PMCID 3657702
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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