Drosophila as a model for chromosomal instability

Abstract Chromosomal instability (CIN) is a common feature of tumours that leads to increased genetic diversity in the tumour and poor clinical outcomes. There is considerable interest in understanding how CIN comes about and how its contribution to drug resistance and metastasis might be counteracted. In the last decade a number of CIN model systems have been developed in Drosophila that offer unique benefits both in understanding the development of CIN in a live animal as well as giving the potential to do genome wide screens for therapeutic candidate genes. This review outlines the mechanisms used in several Drosophila CIN model systems and summarizes some significant outcomes and opportunities that they have produced.

• Publication year

  2014

• Venue

  AIMS Genetics

• Publication date

  2014-12-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3934/genet.2015.1.1
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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• The mitotic origin of chromosomal instability.

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• Chromosomal Instability, Aneuploidy, and Cancer

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• Acentrosomal Drosophila epithelial cells exhibit abnormal cell division, leading to cell death and compensatory proliferation.

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• JNK signaling is needed to tolerate chromosomal instability

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• Chromosomal instability causes sensitivity to metabolic stress

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• Aneuploidy and tumorigenesis in Drosophila.

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• The origins and processing of ultra fine anaphase DNA bridges.

  2014cited by this paper
• Tetraploidy and tumor development

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• Modulation of oxidative stress as an anticancer strategy

  2013cited by this paper
• Constitutional trisomy 8 mosaicism as a model for epigenetic studies of aneuploidy

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• Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors

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  2013cited by this paper
• Transcriptome and proteome quantification of a tumor model provides novel insights into post‐transcriptional gene regulation

  2013cited by this paper
• Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells

  2013cited by this paper
• Transcriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptation

  2013cited by this paper
• Drosophila as a Model for Context‐Dependent Tumorigenesis

  2013cited by this paper
• Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics

  2013cited by this paper
• Dissecting social cell biology and tumors using Drosophila genetics.

  2013cited by this paper
• Caspase signalling in the absence of apoptosis drives Jnk‐dependent invasion

  2013cited by this paper
• Endoreplication and polyploidy: insights into development and disease

  2013cited by this paper
• Misregulation of an adaptive metabolic response contributes to the age-related disruption of lipid homeostasis in Drosophila.

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• A tumor suppressor role of the Bub3 spindle checkpoint protein after apoptosis inhibition

  2013cited by this paper
• The cancer biology of whole-chromosome instability

  2013cited by this paper
• Aneuploidy causes proteotoxic stress in yeast.

  2012cited by this paper
• Chromosomal instability and aneuploidy in cancer: from yeast to man

  2012cited by this paper
• New insights into the troubles of aneuploidy.

  2012cited by this paper
• Aneuploidy-induced delaminating cells drive tumorigenesis in Drosophila epithelia

  2012cited by this paper
• Cancer chromosomal instability: therapeutic and diagnostic challenges

  2012cited by this paper
• A Screen for Selective Killing of Cells with Chromosomal Instability Induced by a Spindle Checkpoint Defect

  2012influential reference
• Buffering and proteolysis are induced by segmental monosomy in Drosophila melanogaster

  2012cited by this paper
• Never tear us apart – the importance of centrosome clustering

  2012cited by this paper
• Transcriptional consequences of aneuploidy

  2012cited by this paper
• ATM Is a Redox Sensor Linking Genome Stability and Carbon Metabolism

  2011cited by this paper
• In vivo mapping of hydrogen peroxide and oxidized glutathione reveals chemical and regional specificity of redox homeostasis.

  2011cited by this paper
• Dissecting protein interactions during cytokinesis

  2011cited by this paper
• Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair.

  2011cited by this paper
• MU2 and HP1a Regulate the Recognition of Double Strand Breaks in Drosophila melanogaster

  2011cited by this paper
• Chemical genetics and drug screening in Drosophila cancer models.

  2011cited by this paper
• Targeting karyotypic complexity and chromosomal instability of cancer cells.

  2010cited by this paper
• Physiological Levels of Reactive Oxygen Species Are Required to Maintain Genomic Stability in Stem Cells

  2010cited by this paper
• Mitotic chromosomal instability and cancer: mouse modelling of the human disease

  2010cited by this paper
• p53-Independent Apoptosis Limits DNA Damage-Induced Aneuploidy

  2009cited by this paper
• Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

  2009cited by this paper
• Identification of Drosophila Mitotic Genes by Combining Co-Expression Analysis and RNA Interference

  2008cited by this paper
• Examining the link between chromosomal instability and aneuploidy in human cells

  2008cited by this paper
• Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.

  2008cited by this paper
• Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint.

  2008cited by this paper
• Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability.

  2008cited by this paper
• Centrosome amplification can initiate tumorigenesis in flies.

  2008cited by this paper
• The Genomic Landscapes of Human Breast and Colorectal Cancers

  2007cited by this paper
• Flies without a spindle checkpoint

  2007cited by this paper
• Does aneuploidy cause cancer?

  2006cited by this paper
• Animal cytokinesis: from parts list to mechanisms.

  2006cited by this paper
• A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy.

  2006cited by this paper
• Tetraploidy and chromosomal instability are early events during cervical carcinogenesis.

  2006cited by this paper
• A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers

  2006cited by this paper
• Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster

  2005cited by this paper
• Cleavage furrow formation and ingression during animal cytokinesis: a microtubule legacy

  2005cited by this paper
• Karyotypic "state" as a potential determinant for anticancer drug discovery.

  2005cited by this paper
• Using Drosophila melanogaster to map human cancer pathways

  2005cited by this paper
• Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

  2005cited by this paper
• Drugs aimed at targeting characteristic karyotypic phenotypes of cancer cells

  2005cited by this paper
• Correcting improper chromosome–spindle attachments during cell division

  2004cited by this paper
• Telomeres: not all breaks are equal.

  2004cited by this paper
• Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B

  2004cited by this paper
• The art and design of genetic screens: Drosophila melanogaster

  2002cited by this paper
• Genetic instabilities in human cancers

  1998cited by this paper
• 17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus.

  1996cited by this paper

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  2017cites this paper
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  2017cites this paper
• Drosophila models of cancer

  2015influential citation