The Tumor Suppressor CYLD Controls the Function of Murine Regulatory T Cells

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Immunology

• Publication date

  2012-11-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.1201993PMID 23066153
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulatory T Cells

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• Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

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• CARMA1 Regulation of Regulatory T Cell Development Involves Modulation of Interleukin-2 Receptor Signaling*

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• Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

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• Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor.

  2009cited by this paper
• CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

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• CD44 Costimulation Promotes FoxP3+ Regulatory T Cell Persistence and Function via Production of IL-2, IL-10, and TGF-β1

  2009cited by this paper
• CTLA‐4 is required by CD4+CD25+ Treg to control CD4+ T‐cell lymphopenia‐induced proliferation

  2009cited by this paper
• The role of NF‐κB and Smad3 in TGF‐β‐mediated Foxp3 expression

  2009cited by this paper
• Control of regulatory T cell lineage commitment and maintenance.

  2009cited by this paper
• CTLA-4 Controls Regulatory T Cell Peripheral Homeostasis and Is Required for Suppression of Pancreatic Islet Autoimmunity1

  2009cited by this paper
• Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome.

  2009cited by this paper
• c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells

  2009cited by this paper
• CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice.

  2009cited by this paper
• Naturally occurring short splice variant of CYLD positively regulates dendritic cell function.

  2009influential reference
• Acquisition of Suppressive Function by Activated Human CD4+CD25− T Cells Is Associated with the Expression of CTLA-4 Not FoxP31

  2008cited by this paper
• Regulatory T cells and immune tolerance.

  2008cited by this paper
• CTLA-4 Control over Foxp3+ Regulatory T Cell Function

  2008cited by this paper
• Deubiquitinating Enzyme CYLD Regulates the Peripheral Development and Naive Phenotype Maintenance of B Cells*♦

  2007cited by this paper
• Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD

  2007influential reference
• Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses

  2007cited by this paper
• Faculty Opinions recommendation of Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling.

  2006cited by this paper
• Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling.

  2006cited by this paper
• Regulation of T cell development by the deubiquitinating enzyme CYLD

  2006cited by this paper
• Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice.

  2006cited by this paper
• Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling

  2005cited by this paper
• Inducing and expanding regulatory T cell populations by foreign antigen

  2005cited by this paper
• Control of lymphocyte development by nuclear factor-kappaB.

  2005cited by this paper
• A function for interleukin 2 in Foxp3-expressing regulatory T cells

  2005cited by this paper
• Control of lymphocyte development by nuclear factor-κB

  2005cited by this paper
• Regulatory T cells.

  2004cited by this paper
• Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

  2003cited by this paper
• Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

  2003cited by this paper
• The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination

  2003cited by this paper
• Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells1

  2003cited by this paper
• CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members

  2003cited by this paper
• Supporting Online Material

  2003cited by this paper
• The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

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• X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

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• Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

  2001cited by this paper
• A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

  2001cited by this paper
• Identification of the familial cylindromatosis tumour-suppressor gene

  2000cited by this paper
• An Essential Role for Nuclear Factor κB in Promoting Double Positive Thymocyte Apoptosis

  1999cited by this paper
• Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

  1995cited by this paper

• The potential impact of RNA splicing abnormalities on immune regulation in endometrial cancer

  2025cites this paper
• MALT1 substrate cleavage: what is it good for?

  2024cites this paper
• Constitutive expression of the deubiquitinating enzyme CYLD does not affect microglia phenotype or function in homeostasis and neuroinflammation

  2024cites this paper
• The Function of Ubiquitination in T-Cell Development.

  2024cites this paper
• Mechanism study of ubiquitination in T cell development and autoimmune disease

  2024cites this paper
• CYLD in health and disease

  2023cites this paper
• Targeting ubiquitin signaling for cancer immunotherapy

  2021cites this paper
• CYLD expression in dendritic cells involved in the immunoregulation of pulmonary adenocarcinoma via NF-κB pathway

  2020cites this paper
• The deubiquitinase CYLD controls protective immunity against helminth infection by regulation of Treg plasticity.

  2020cites this paper
• Deubiquitinating Enzyme: A Potential Secondary Checkpoint of Cancer Immunity

  2020cites this paper
• Alternative Splice Forms of CYLD Mediate Ubiquitination of SMAD7 to Prevent TGFB Signaling and Promote Colitis.

  2019cites this paper
• Foxp3 Post-translational Modifications and Treg Suppressive Activity

  2019cites this paper
• Regulation of T cell differentiation and function by ubiquitin-specific proteases.

  2019cites this paper
• Nuclear Factor-kappaB in Autoimmunity: Man and Mouse

  2018cites this paper
• The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis

  2018cites this paper
• Deubiquitinases as pivotal regulators of T cell functions

  2018cites this paper
• Notch and NF-κB: Coach and Players of Regulatory T-Cell Response in Cancer

  2018cites this paper
• Rediscovery of NF‐κB signaling in nasopharyngeal carcinoma: How genetic defects of NF‐κB pathway interplay with EBV in driving oncogenesis?

  2018cites this paper
• Cylindromatosis (CYLD), a Deubiquitinase, Attenuates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells

  2017cites this paper
• A20 Restrains Thymic Regulatory T Cell Development

  2017cites this paper
• Monitoring of Chemically Induced Colitis.

  2017cites this paper
• CYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death: so similar, yet so different

  2017cites this paper
• Immune Regulation by Ubiquitin Tagging as Checkpoint Code.

  2017cites this paper
• Ubiquitin enzymes in the regulation of immune responses

  2017cites this paper
• miR‐181d regulates human dendritic cell maturation through NF‐κB pathway

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• Cylindromatosis (Cyld) gene mutation in T cells promotes the development of an IL-9-dependent allergic phenotype in experimental asthma.

  2016cites this paper
• Ubiquitin‐dependent regulation of Foxp3 and Treg function

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• MicroRNA transcriptomes of distinct human NK cell populations identify miR-362-5p as an essential regulator of NK cell function

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  2015cites this paper
• CYLD-mediated signaling and diseases.

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