The γ-secretase blocker DAPT impairs recovery from lipopolysaccharide-induced inflammation in rat brain.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Neuroscience

• Publication date

  2012-05-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.neuroscience.2012.02.051PMID 22445932
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Don't Eat Me

  2011cited by this paper
• Therapeutic intervention for Alzheimer's disease with γ-secretase inhibitors: still a viable option?

  2011cited by this paper
• Immune system to brain signaling: neuropsychopharmacological implications.

  2011cited by this paper
• γ-secretase substrates and their implications for drug development in Alzheimer's disease.

  2011cited by this paper
• Targets for AD treatment: conflicting messages from γ‐secretase inhibitors

  2011cited by this paper
• Presenilin 2 Is the Predominant γ-Secretase in Microglia and Modulates Cytokine Release

  2010cited by this paper
• Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra

  2010cited by this paper
• Nuclear factor‐κB/p65 responds to changes in the Notch signaling pathway in murine BV‐2 cells and in amoeboid microglia in postnatal rats treated with the γ‐secretase complex blocker DAPT

  2010cited by this paper
• Alzheimer's failure raises questions about disease-modifying strategies

  2010cited by this paper
• Inflammation in neurodegenerative diseases

  2010cited by this paper
• The dance of the perivascular and endothelial cells: mechanisms of brain response to immune signaling.

  2010cited by this paper
• REVIEW: γ‐Secretase Inhibitors for the Treatment of Alzheimer's Disease: The Current State

  2010cited by this paper
• Cutting Edge: Plasmacytoid Dendritic Cells Induce IL-10 Production in T Cells via the Delta-Like-4/Notch Axis

  2009cited by this paper
• (-)-Epigallocatechin-3-gallate prevents lipopolysaccharide-induced elevation of beta-amyloid generation and memory deficiency.

  2009cited by this paper
• The Multiple Roles of the Innate Immune System in the Regulation of Apoptosis and Inflammation in the Brain

  2009cited by this paper
• Increased expression of the γ‐secretase components presenilin‐1 and nicastrin in activated astrocytes and microglia following traumatic brain injury

  2008cited by this paper
• Cerebrospinal Fluid Research BioMed Central Review Multiplicity of cerebrospinal fluid functions: New challenges in health and disease

  2008cited by this paper
• Welcome to Molecular Brain

  2008cited by this paper
• Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein

  2008cited by this paper
• Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein.

  2008cited by this paper
• Notch regulates IL-10 production by T helper 1 cells

  2008cited by this paper
• Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin.

  2008cited by this paper
• Activity of gamma-secretase on substrates other than APP.

  2008cited by this paper
• Selective contribution of interleukin‐6 and leptin to brain inflammatory signals induced by systemic LPS injection in mice

  2008cited by this paper
• Regulated intramembrane proteolysis of the low-density lipoprotein receptor-related protein mediates ischemic cell death.

  2008cited by this paper
• γ-Secretase Limits the Inflammatory Response Through the Processing of LRP1

  2008cited by this paper
• Expression of Notch‐1 receptor and its ligands Jagged‐1 and Delta‐1 in amoeboid microglia in postnatal rat brain and murine BV‐2 cells

  2008cited by this paper
• Activity of γ -Secretase on Substrates Other than APP

  2008cited by this paper
• Multiplicity of cerebrospinal fluid functions: New challenges in health and disease

  2008cited by this paper
• Oxidative stress activates a positive feedback between the γ‐ and β‐secretase cleavages of the β‐amyloid precursor protein

  2007cited by this paper
• Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

  2007cited by this paper
• Innate immunity and protective neuroinflammation: new emphasis on the role of neuroimmune regulatory proteins.

  2007cited by this paper
• CD4+CD25−Foxp3− Th1 cells are the source of IL-10–mediated immune suppression in chronic cutaneous leishmaniasis

  2007cited by this paper
• Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for glial and neural-related molecules in central nervous system mixed glial cell cultures: neurotrophins, growth factors and structural proteins

  2007cited by this paper
• Notch signaling modulates the activation of microglial cells

  2007cited by this paper
• Presenilin: running with scissors in the membrane.

  2007cited by this paper
• Brain-immune communication pathways.

  2007cited by this paper
• Conventional T-bet+Foxp3− Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection

  2007cited by this paper
• Gamma secretase–mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke

  2006cited by this paper
• Self-Limitation of Th1-Mediated Inflammation by IFN-γ1

  2006cited by this paper
• Resolution of in flammation: state of the art, definitions and terms

  2006cited by this paper
• ERK1/2 is an endogenous negative regulator of the γsecretase activity

  2006cited by this paper
• Peripheral lipopolysaccharide induces apoptosis in the murine olfactory bulb.

  2005cited by this paper
• The nervous system and innate immunity: the neuropeptide connection.

  2005cited by this paper
• Systemic inflammation induces apoptosis with variable vulnerability of different brain regions.

  2005cited by this paper
• Effects of intraperitoneal lipopolysaccharide on Morris maze performance in year-old and 2-month-old female C57BL/6J mice.

  2005cited by this paper
• Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation.

  2005cited by this paper
• Indolamine 2,3‐dioxygenase is expressed in the CNS and down‐regulates autoimmune inflammation

  2005cited by this paper
• Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21

  2005cited by this paper
• Self-Renewal and Cancer of the Gut: Two Sides of a Coin

  2005cited by this paper
• Neuroinflammation: a potential therapeutic target

  2005cited by this paper
• Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration

  2005cited by this paper
• Minireview: Development and differentiation of gut endocrine cells.

  2004cited by this paper
• Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation.

  2004cited by this paper
• Effect of systemic LPS injection on cortical NF-kappaB activity and inflammatory response following traumatic brain injury in rats.

  2004cited by this paper
• Notch 1 signaling regulates peripheral T cell activation.

  2004cited by this paper
• The gamma-secretase complex: machinery for intramembrane proteolysis.

  2004cited by this paper
• Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation.

  2004cited by this paper
• The γ-secretase complex: machinery for intramembrane proteolysis

  2004cited by this paper
• Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation*

  2004cited by this paper
• Cues for apoptotic cell engulfment: eat-me, don't eat-me and come-get-me signals.

  2003cited by this paper
• "Eat me" and "don't eat me" signals govern the innate immune response and tissue repair in the CNS: emphasis on the critical role of the complement system.

  2003cited by this paper
• Adipsin, a Biomarker of Gastrointestinal Toxicity Mediated by a Functional γ-Secretase Inhibitor*

  2003cited by this paper
• Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages.

  2003cited by this paper
• Catalytic Site-Directed γ-Secretase Complex Inhibitors Do Not Discriminate Pharmacologically between Notch S3 and β-APP Cleavages

  2003cited by this paper
• Brain-specific endothelial induction of prostaglandin E(2) synthesis enzymes and its temporal relation to fever.

  2002cited by this paper
• Signalling: γ-Secretase-mediated proteolysis in cell-surface-receptor signalling

  2002cited by this paper
• Systemic LPS injection leads to granulocyte influx into normal and injured brain: effects of ICAM-1 deficiency.

  2001cited by this paper
• Implication of Glutamate in the Expression of Inducible Nitric Oxide Synthase After Oxygen and Glucose Deprivation in Rat Forebrain Slices

  2000cited by this paper
• Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain

  2000cited by this paper
• Local Neurochemicals and Site‐Specific Immune Regulation in the CNS

  2000cited by this paper
• Lipopolysaccharide Injected into the Cerebral Ventricle Evokes Fever through Induction of Cyclooxygenase-2 in Brain Endothelial Cells

  1999cited by this paper
• Notch signaling: cell fate control and signal integration in development.

  1999cited by this paper
• Notch Signaling : Cell Fate Control and Signal Integration in Development

  1999cited by this paper
• Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

  1999cited by this paper
• Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

  1998cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper

• Impact prediction of translocation of the mitochondrial outer membrane 70 as biomarker in Alzheimer's disease

  2022cites this paper
• The Notch Signaling Pathway Regulates Differentiation of NG2 Cells into Oligodendrocytes in Demyelinating Diseases

  2021cites this paper
• Preactivation of Notch1 in remote ischemic preconditioning reduces cerebral ischemia-reperfusion injury through crosstalk with the NF-κB pathway

  2019cites this paper
• Lentivirus-mediated overexpression of OTULIN ameliorates microglia activation and neuroinflammation by depressing the activation of the NF-κB signaling pathway in cerebral ischemia/reperfusion rats

  2018cites this paper
• Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization

  2017cites this paper
• Portulaca oleracea L. prevents lipopolysaccharide-induced passive avoidance learning and memory and TNF-α impairments in hippocampus of rat.

  2017cites this paper
• The Effects of Pentoxifylline on Serum Levels of Interleukin 10 and Interferon Gamma and Memory Function in Lipopolysaccharide-induced Inflammation in Rats

  2017cites this paper
• Effects of the Notch signalling pathway on hyperoxia-induced immature brain damage in newborn mice.

  2017cites this paper
• Blockade of Notch signaling promotes acetaminophen-induced liver injury

  2017cites this paper
• Phosphatase and tensin homolog–β‐catenin signaling modulates regulatory T cells and inflammatory responses in mouse liver ischemia/reperfusion injury

  2017cites this paper
• Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity

  2016cites this paper
• Lingo-1 shRNA and Notch signaling inhibitor DAPT promote differentiation of neural stem/progenitor cells into neurons.

  2016cites this paper
• IL-17A is implicated in lipopolysaccharide-induced neuroinflammation and cognitive impairment in aged rats via microglial activation

  2015cites this paper
• Omega-3 fatty acids prevent LPS-induced passive avoidance learning and memory and CaMKII-α gene expression impairments in hippocampus of rat

  2015cites this paper
• Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice

  2013cites this paper