Very Long-term Survival Following Resection for Pancreatic Cancer Is Not Explained by Commonly Mutated Genes: Results of Whole-Exome Sequencing Analysis

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Clinical Cancer Research

• Publication date

  2015-01-26

• Fields of study

  Medicine

• Identifiers
  DOI 10.1158/1078-0432.CCR-14-2600PMID 25623214PMCID PMC4401626
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pancreatectomy predicts improved survival for pancreatic adenocarcinoma: results of an instrumental variable analysis.

  2015cited by this paper
• Exome sequencing identifies a novel EP300 frame shift mutation in a patient with features that overlap cornelia de lange syndrome

  2014cited by this paper
• Comprehensive molecular characterization of gastric adenocarcinoma

  2014cited by this paper
• Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas

  2014cited by this paper
• 2564 resected periampullary adenocarcinomas at a single institution: trends over three decades.

  2014cited by this paper
• Cancer treatment and survivorship statistics, 2014

  2014cited by this paper
• Whole‐exome sequencing of pancreatic neoplasms with acinar differentiation

  2014cited by this paper
• Clinicopathological Correlates of Activating GNAS Mutations in Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas

  2013cited by this paper
• Genetic alterations associated with progression from pancreatic intraepithelial neoplasia to invasive pancreatic tumor.

  2013cited by this paper
• Pancreatic cancer.

  2013cited by this paper
• Does long‐term survival in patients with pancreatic cancer really exist?—Results from the CONKO‐001 study

  2013cited by this paper
• FAST-SeqS: A Simple and Efficient Method for the Detection of Aneuploidy by Massively Parallel Sequencing

  2012cited by this paper
• Pancreatic cancer: surgical management and outcomes after 6 years of follow‐up

  2012influential reference
• Clinical Significance of the Genetic Landscape of Pancreatic Cancer and Implications for Identification of Potential Long-term Survivors

  2012cited by this paper
• Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

  2012cited by this paper
• The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

  2012cited by this paper
• Pancreatic ductal adenocarcinoma: long-term survival does not equal cure.

  2012cited by this paper
• Pancreatic cancer: surgical management and outcomes after 6 years of follow‐up

  2012cited by this paper
• Pancreatic cancer; reporting and long-term survival in Sweden

  2011cited by this paper
• Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development

  2011cited by this paper
• Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

  2011cited by this paper
• Detection and quantification of rare mutations with massively parallel sequencing

  2011cited by this paper
• CA : A Cancer Journal for Clinicians

  2011cited by this paper
• Pancreatic cancer

  2011cited by this paper
• Histopathologic Basis for the Favorable Survival after Resection of Intraductal Papillary Mucinous Neoplasm-Associated Invasive Adenocarcinoma of the Pancreas

  2010influential reference
• Hepatocyte Growth Factor Reduces Susceptibility to an Irreversible Epidermal Growth Factor Receptor Inhibitor in EGFR-T790M Mutant Lung Cancer

  2010cited by this paper
• Pancreatic cancer.

  2010cited by this paper
• International network of cancer genome projects

  2010cited by this paper
• Analysis of 5-Year Survivors After a Macroscopic Curative Pancreatectomy for Invasive Ductal Adenocarcinoma

  2010cited by this paper
• Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging Agents in Pancreatic Cancer

  2010cited by this paper
• Identifying pancreatic cancer patients for targeted treatment: the challenges and limitations of the current selection process and vision for the future

  2010cited by this paper
• International network of cancer genome projects

  2010cited by this paper
• Long-Term Survival After Multidisciplinary Management of Resected Pancreatic Adenocarcinoma

  2009cited by this paper
• SMAD4 Gene Mutations Are Associated with Poor Prognosis in Pancreatic Cancer

  2009cited by this paper
• Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene

  2009cited by this paper
• DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer.

  2009cited by this paper
• Pancreatic Adenocarcinoma: The Actual 5-Year Survivors

  2008cited by this paper
• Mucinous Cystic Neoplasm of the Pancreas is Not an Aggressive Entity: Lessons From 163 Resected Patients

  2008cited by this paper
• Long-term survivors among Danish patients after resection for ductal adenocarcinoma of the pancreas

  2008cited by this paper
• Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

  2008cited by this paper
• Long-Term Survival (5-20 Years) After Pancreatectomy for Pancreatic Ductal Adenocarcinoma: A Series of 30 Patients Collected From 3 Institutions

  2008cited by this paper
• Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma.

  2007cited by this paper
• Tumors of the Pancreas (Atlas of Tumor Pathology Series 4)

  2007cited by this paper
• Analysis of Long-term Survivors After Surgical Resection for Pancreatic Cancer

  2006cited by this paper
• Resected periampullary adenocarcinoma: 5-year survivors and their 6- to 10-year follow-up.

  2006cited by this paper
• Targeting the DNA repair defect of BRCA tumours.

  2005cited by this paper
• Analysis of long-term survivors after surgical resection for invasive pancreatic cancer.

  2005cited by this paper
• Fanconi anemia gene mutations in young-onset pancreatic cancer.

  2003cited by this paper
• AJCC cancer staging handbook : from the AJCC cancer staging manual

  2002cited by this paper
• The Dichotomy in the Preinvasive Neoplasia to Invasive Carcinoma Sequence in the Pancreas: Differential Expression of MUC1 and MUC2 Supports the Existence of Two Separate Pathways of Carcinogenesis

  2002influential reference
• The n e w e n g l a n d j o u r n a l of m e d i c i n e

  2001cited by this paper
• The society for surgery of the alimentary tract postgraduate course

  1982cited by this paper
• Atlas of tumor pathology

  1954cited by this paper
• Tumors of the pancreas.

  1951cited by this paper

• The dual role of gut microbiota in pancreatic cancer: new insights into onset and treatment

  2025cites this paper
• Incidental Diagnosis of Pancreatic Cancer and Association with Improved Patient Outcomes: Assessing the Potential Clinical Utility of Liquid Biopsy Based Screening Tests.

  2025cites this paper
• 10-year survival after resection of pancreatic ductal adenocarcinoma with pathological re-examination of a nationwide cohort.

  2025cites this paper
• Mapping the Proteomic Landscape of Pancreatic Cancer: Prognostic Insights and Subtype Stratification

  2025cites this paper
• Classic versus innovative strategies for immuno-therapy in pancreatic cancer.

  2025cites this paper
• The Relationship of the Microbiome, Associated Metabolites and the Gut Barrier with Pancreatic Cancer.

  2025cites this paper
• Predictors for Long-Term Survival After Resection of Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis

  2024cites this paper
• The tumor immune microenvironment in resected treatment-naive pancreatic cancer patients with long-term survival.

  2024cites this paper
• Roadmap for providing and leveraging annotated data by cytologists in the PDAC domain as open data: support for AI-based pathology image analysis development and data utilization strategies

  2024cites this paper
• Prolonged length of stay and omission of adjuvant therapy are associated with early mortality after pancreatic adenocarcinoma resection

  2024cites this paper
• Analysis of the fecal metagenome in long‐term survivors of pancreas cancer

  2023cites this paper
• Metagenomic analysis unveils the microbial landscape of pancreatic tumors

  2023cites this paper
• Clinical features of germline BRCA1/2 or ATM pathogenic variant positive pancreatic cancer in Japan.

  2023cites this paper
• Galectin-1 in Pancreatic Ductal Adenocarcinoma: Bridging Tumor Biology, Immune Evasion, and Therapeutic Opportunities

  2023cites this paper
• Splicing alterations in pancreatic ductal adenocarcinoma: a new molecular landscape with translational potential

  2023cites this paper
• Predicting Long-term Disease-free Survival After Resection of Pancreatic Ductal Adenocarcinoma

  2023cites this paper
• Agrimoniin is a dual inhibitor of AKT and ERK pathways that inhibit pancreatic cancer cell proliferation

  2023cites this paper
• SETD8 inhibits ferroptosis in pancreatic cancer by inhibiting the expression of RRAD

  2023cites this paper
• A Comprehensive Review of the Current and Future Role of the Microbiome in Pancreatic Ductal Adenocarcinoma

  2022cites this paper
• Differentiation of pancreatic ductal adenocarcinoma and chronic pancreatitis using graph neural networks on histopathology and collagen fiber features

  2022cites this paper
• Suppressive effect of YY1-mediated RGS22 regulation on the proliferation, migration and invasion of pancreatic ductal adenocarcinoma

  2022cites this paper
• Artificial intelligence in pancreatic cancer

  2022cites this paper
• Neoantigens and their clinical applications in human gastrointestinal cancers

  2022cites this paper
• Single Cell RNA Sequencing: A New Frontier in Pancreatic Ductal Adenocarcinoma

  2022cites this paper
• Cellular metabolism in pancreatic cancer as a tool for prognosis and treatment (Review)

  2022cites this paper
• Establishment and Application of a Novel Difficulty Scoring System for da Vinci Robotic Pancreatoduodenectomy

  2022cites this paper
• Predictors of Long-Term Survival in Pancreatic Ductal Adenocarcinoma after Pancreatectomy: TP53 and SMAD4 Mutation Scoring in Combination with CA19-9

  2022cites this paper
• Isolated Pancreatic Metastases of Renal Cell Cancer: Genetics and Epigenetics of an Unusual Tumour Entity

  2022cites this paper
• Vascular Resections in Association With Pancreatic Resections for Locally Advanced Pancreatic Cancer

  2022cites this paper
• Could fecal microbial transplantation offer a new potential in the treatment of metastatic pancreatic ductal adenocarcinoma?

  2022cites this paper
• Genetic Alterations Predict Long-Term Survival in Ductal Adenocarcinoma of the Pancreatic Head

  2022cites this paper
• Impact of completeness of adjuvant gemcitabine, relapse pattern, and subsequent therapy on outcome of patients with resected pancreatic ductal adenocarcinoma - A pooled analysis of CONKO-001, CONKO-005, and CONKO-006 trials.

  2021cites this paper
• ACTR3 promotes cell migration and invasion by inducing epithelial mesenchymal transition in pancreatic ductal adenocarcinoma.

  2021cites this paper
• Metagenomic analysis of gut microbiome reveals a dynamic change in Alistipes onderdonkii in the preclinical model of pancreatic cancer, suppressing its proliferation

  2021cites this paper
• Genomic Heterogeneity of Pancreatic Ductal Adenocarcinoma and Its Clinical Impact

  2021cites this paper
• Identification of KRAS G12V associated clonal neoantigens and immune microenvironment in long-term survival of pancreatic adenocarcinoma

  2021influential citation
• Hallmarks of cancer—the new testament

  2021cites this paper
• A Four-Methylated lncRNAs-Based Prognostic Signature for Hepatocellular Carcinoma

  2020cites this paper
• Development of a four-gene prognostic model for pancreatic cancer based on transcriptome dysregulation

  2020cites this paper
• Correction to: Twelve Hundred Consecutive Pancreato-Duodenectomies from Single Centre: Impact of Centre of Excellence on Pancreatic Cancer Surgery Across India

  2020cites this paper
• The YY1/miR-548t-5p/CXCL11 signaling axis regulates cell proliferation and metastasis in human pancreatic cancer

  2020cites this paper
• BRCA Mutations in Pancreas Cancer: Spectrum, Current Management, Challenges and Future Prospects

  2020cites this paper
• Hypoxia: Friend or Foe for drug delivery in Pancreatic Cancer.

  2020cites this paper
• Pros and Cons: High Proportion of Stromal Component Indicates Better Prognosis in Patients With Pancreatic Ductal Adenocarcinoma—A Research Based on the Evaluation of Whole-Mount Histological Slides

  2020cites this paper
• Identification of genomic alterations and associated transcriptomic profiling reveal the prognostic significance of MMP14 and PKM2 in patients with pancreatic cancer

  2020cites this paper
• STRAP as a New Therapeutic Target for Poor Prognosis of Pancreatic Ductal Adenocarcinoma Patients Mainly Caused by TP53 Mutation

  2020cites this paper
• The actual 5-year survivors of pancreatic ductal adenocarcinoma based on real-world data

  2020cites this paper
• SETD8 potentiates constitutive ERK1/2 activation via epigenetically silencing DUSP10 expression in pancreatic cancer.

  2020cites this paper
• CMAR_A_211151 2731..2742

  2020cites this paper
• The Role of F11R in Pancreatic Cancer Malignancy and Its Clinical Implication as a Therapeutic Target

  2019cites this paper
• Dissecting the molecular landscape of pancreatic cancer: towards a precision medicine approach

  2019cites this paper
• DNA sequencing of cytopathologically inconclusive EUS-FNA from solid pancreatic lesions suspicious for malignancy confirms EUS diagnosis

  2019cites this paper
• Genomics meets immunity in pancreatic cancer: Current research and future directions for pancreatic adenocarcinoma immunotherapy

  2019cites this paper
• Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes.

  2019cites this paper
• Why is pancreatic cancer so deadly? The pathologist's view

  2019cites this paper
• Keratin 17 identifies the most lethal molecular subtype of pancreatic cancer

  2019cites this paper
• Evolutionary Origins of Recurrent Pancreatic Cancer

  2019cites this paper
• Analysis of CDKN2A gene alterations in recurrent and non-recurrent meningioma

  2019cites this paper
• Twelve Hundred Consecutive Pancreato-Duodenectomies from Single Centre: Impact of Centre of Excellence on Pancreatic Cancer Surgery Across India

  2019cites this paper
• Disparities in the Use of Chemotherapy in Patients with Resected Pancreatic Ductal Adenocarcinoma

  2019cites this paper
• CHARACERIZING DRIVER GENE HETEROGENEITY AND CLONAL ORIGIN OF INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS OF THE PANCREAS

  2019cites this paper
• SERPINB7 Expression Predicts Poor Pancreatic Cancer Survival Upon Gemcitabine Treatment

  2018cites this paper
• Identification of genes highly downregulated in pancreatic cancer through a meta-analysis of microarray datasets: implications for discovery of novel tumor-suppressor genes and therapeutic targets

  2018cites this paper
• Tumour budding in pancreatic cancer revisited: validation of the ITBCC scoring system

  2018cites this paper
• IPMNs with co-occurring invasive cancers: neighbours but not always relatives

  2018cites this paper
• A novel scoring system predicts postsurgical survival and adjuvant chemotherapeutic benefits in patients with pancreatic adenocarcinoma: Implications for AJCC‐TNM staging

  2018cites this paper
• Precision medicine based on next-generation sequencing and master controllers

  2018cites this paper
• From somatic mutation to early detection: insights from molecular characterization of pancreatic cancer precursor lesions

  2018cites this paper
• Multimodal treatment of resectable pancreatic ductal adenocarcinoma.

  2017cites this paper
• Genetic Profiling of Cancers of the Digestive System: Biological Insights and Clinical Implications

  2017cites this paper
• Chapter 5 – The Genomic Landscape of Cancers

  2017cites this paper
• The history and evolution of pancreaticoduodenectomy

  2017cites this paper
• Exosome targeted therapy—a step in the future

  2017cites this paper
• New Developments in the Molecular Mechanisms of Pancreatic Tumorigenesis.

  2017cites this paper
• Key biological processes driving metastatic spread of pancreatic cancer as identified by multi-omics studies.

  2017cites this paper
• Computational discovery of tissue morphology biomarkers in very long-term survivors with pancreatic ductal adenocarcinoma

  2017influential citation
• CA19-9-Low&Lewis (+) pancreatic cancer: A unique subtype.

  2017cites this paper
• Long-term survivors of pancreatic adenocarcinoma show low rates of genetic alterations in KRAS, TP53 and SMAD4

  2017influential citation
• From Clinical Standards to Translating Next-Generation Sequencing Research into Patient Care Improvement for Hepatobiliary and Pancreatic Cancers

  2017influential citation
• Next generation sequencing of pancreatic ductal adenocarcinoma: right or wrong?

  2017cites this paper
• Never let it go: Stopping key mechanisms underlying metastasis to fight pancreatic cancer.

  2017cites this paper
• Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine.

  2016cites this paper
• SMAD4 loss enables EGF, TGFβ1 and S100A8/A9 induced activation of critical pathways to invasion in human pancreatic adenocarcinoma cells

  2016cites this paper
• Molecular Genetics of Pancreatic Neoplasms.

  2016cites this paper
• Macrophages and pancreatic ductal adenocarcinoma.

  2016cites this paper
• Highly aligned stromal collagen is a negative prognostic factor following pancreatic ductal adenocarcinoma resection

  2016cites this paper
• Long-term survival in patients with pancreatic ductal adenocarcinoma.

  2016cites this paper
• The role of hypoxia in pancreatic cancer: a potential therapeutic target?

  2016cites this paper
• Bioinformatic analysis reveals pancreatic cancer molecular subtypes specific to the tumor and the microenvironment

  2016cites this paper
• Análisis de la heterogeneidad genética del adenocarcinoma ductal de páncreas y su relación con las características de la enfermedad

  2015cites this paper
• Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

  2015cites this paper
• Pancreatic cancer surgery: past, present, and future.

  2015cites this paper
• Very long-term survival in pancreatic cancer

  2015cites this paper
• Quoi de neuf en recherche fondamentale et translationnelle sur le cancer du pancréas ?

  2015cites this paper