Chemoattractants and receptors in Alzheimer's disease.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Frontiers in Bioscience

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2741/S81PMID 20036964
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Peripheral T cells derived from Alzheimer's disease patients overexpress CXCR2 contributing to its transendothelial migration, which is microglial TNF-alpha-dependent.

  2010influential reference
• RANTES upregulation in the Alzheimer's disease brain: a possible neuroprotective role.

  2010influential reference
• Monocyte Chemoattractant Protein‐1 Plays a Dominant Role in the Chronic Inflammation Observed in Alzheimer's Disease

  2009cited by this paper
• Chemokines and chemokine receptors: an overview.

  2009cited by this paper
• AAV1/2-mediated CNS Gene Delivery of Dominant-negative CCL2 Mutant Suppresses Gliosis, β-amyloidosis, and Learning Impairment of APP/PS1 Mice.

  2009cited by this paper
• Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway.

  2009cited by this paper
• Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition.

  2008cited by this paper
• A rescue factor for Alzheimer's diseases: discovery, activity, structure, and mechanism.

  2008cited by this paper
• Decreased CXCL12 (SDF-1) Plasma Levels in Early Alzheimer's Disease: A Contribution to a Deficient Hematopoietic Brain Support?

  2008cited by this paper
• All-or-nothing type biphasic cytokine production of human lymphocytes after exposure to Alzheimer's beta-amyloid peptide.

  2008cited by this paper
• Decreased Fractalkine and Increased IP-10 Expression in Aged Brain of APPswe Transgenic Mice

  2008cited by this paper
• Peripheral Chemokine Receptors, Their Ligands, Cytokines and Alzheimer's Disease

  2008influential reference
• Involvement of formyl-peptide-receptor-like-1 and phospholipase D in the internalization and signal transduction of amyloid beta 1-42 in glial cells.

  2008cited by this paper
• Novel role of CXCR2 in regulation of gamma-secretase activity.

  2008cited by this paper
• Changes in the levels of plasma soluble fractalkine in patients with mild cognitive impairment and Alzheimer's disease.

  2008cited by this paper
• Functional consequences of locus coeruleus degeneration in Alzheimer's disease.

  2008cited by this paper
• Association between the macrophage inflammatory protein-l alpha gene polymorphism and Alzheimer's disease in the Chinese population.

  2008cited by this paper
• IP‐10 serum levels are not increased in mild cognitive impairment and Alzheimer's disease

  2007cited by this paper
• Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues.

  2007influential reference
• Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease.

  2007cited by this paper
• Peripheral T cells overexpress MIP-1alpha to enhance its transendothelial migration in Alzheimer's disease.

  2007influential reference
• Expression of Macrophage Inflammatory Protein 1-α is Elevated in Alzheimer's Vessels and is Regulated by Oxidative Stress

  2007influential reference
• CXC chemokine receptor 4 regulates neuronal migration and axonal pathfinding in the developing nervous system: implications for neuronal regeneration in the adult brain.

  2007cited by this paper
• Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease

  2007cited by this paper
• Multiple actions of the chemokine stromal cell-derived factor-1alpha on neuronal activity.

  2007cited by this paper
• Modulation of interleukin-1β mediated inflammatory response in human astrocytes by flavonoids: Implications in neuroprotection

  2007cited by this paper
• IL-8 Induces Expression of Matrix Metalloproteinases, Cell Cycle and Pro-Apoptotic Proteins, and Cell Death in Cultured Neurons

  2007cited by this paper
• Reduced CXCL12/CXCR4 results in impaired learning and is downregulated in a mouse model of Alzheimer disease.

  2007cited by this paper
• Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease.

  2007cited by this paper
• Intrathecal chemokine synthesis in mild cognitive impairment and Alzheimer disease.

  2006influential reference
• Role of toll-like receptor signalling in Abeta uptake and clearance.

  2006cited by this paper
• CXCL10‐induced cell death in neurons: role of calcium dysregulation

  2006cited by this paper
• Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer's disease.

  2006cited by this paper
• Amyloid-β peptides induce several chemokine mRNA expressions in the primary microglia and Ra2 cell line via the PI3K/Akt and/or ERK pathway

  2006cited by this paper
• RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein‐coupled receptor 75

  2006influential reference
• Activation of Toll-like Receptor 2 on Microglia Promotes Cell Uptake of Alzheimer Disease-associated Amyloid β Peptide*

  2006cited by this paper
• A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development

  2006influential reference
• Thrombin and inflammatory proteins are elevated in Alzheimer's disease microvessels: Implications for disease pathogenesis

  2006cited by this paper
• Association between the Polymorphism of CCR5 and Alzheimer's Disease

  2006cited by this paper
• Anti-inflammatory effect of jeongshintang through suppression of p38 activation in human astrocytoma, U373MG cells.

  2006influential reference
• Locus Ceruleus Degeneration Promotes Alzheimer Pathogenesis in Amyloid Precursor Protein 23 Transgenic Mice

  2006cited by this paper
• Control of microglial neurotoxicity by the fractalkine receptor

  2006cited by this paper
• The chemokine and chemokine receptor superfamilies and their molecular evolution

  2006cited by this paper
• Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice

  2005cited by this paper
• Expression and production of two selected beta-chemokines in peripheral blood mononuclear cells from patients with Alzheimer's disease.

  2005cited by this paper
• Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases.

  2005cited by this paper
• Mechanism of amyloid peptide induced CCR5 expression in monocytes and its inhibition by siRNA for Egr-1.

  2005cited by this paper
• Measurement of Thirteen Biological Markers in CSF of Patients with Alzheimer’s Disease and Other Dementias

  2005cited by this paper
• CpG‐containing oligodeoxynucleotide promotes microglial cell uptake of amyloid β 1–42 peptide by up‐regulating the expression of the G‐protein‐coupled receptor mFPR2

  2005cited by this paper
• Chemokines and brain functions.

  2005cited by this paper
• Age-Dependent Changes in CXC Chemokine Ligand 10 Serum Levels in Euthyroid Subjects

  2005cited by this paper
• Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population.

  2005cited by this paper
• IL-8 enhancement of amyloid-beta (Aβ1-42)-induced expression and production of pro-inflammatory cytokines and COX-2 in cultured human microglia

  2005cited by this paper
• Macrophage inflammatory protein 2 inhibits beta-amyloid peptide (1-42)-mediated hippocampal neuronal apoptosis through activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways.

  2005cited by this paper
• Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition.

  2005cited by this paper
• No evidence for association of the monocyte chemoattractant protein-1 (-2518) gene polymorphism and Alzheimer's disease.

  2004cited by this paper
• Curcumin, the active constituent of turmeric, inhibits amyloid peptide‐induced cytochemokine gene expression and CCR5‐mediated chemotaxis of THP‐1 monocytes by modulating early growth response‐1 transcription factor

  2004cited by this paper
• Humanin, a Newly Identified Neuroprotective Factor, Uses the G Protein-Coupled Formylpeptide Receptor-Like-1 as a Functional Receptor1

  2004influential reference
• The chemokine receptor CCR5-Δ32 gene mutation is not protective against Alzheimer’s disease

  2004cited by this paper
• Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease.

  2004cited by this paper
• Binding sites of amyloid beta-peptide in cell plasma membrane and implications for Alzheimer's disease.

  2004cited by this paper
• Ginger Extract Inhibits β-Amyloid Peptide–Induced Cytokine and Chemokine Expression in Cultured THP-1 Monocytes

  2004cited by this paper
• Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism and risk of Alzheimer's disease in Italians.

  2004cited by this paper
• IL-10 and glucocorticoids inhibit Abeta(1-42)- and lipopolysaccharide-induced pro-inflammatory cytokine and chemokine induction in the central nervous system.

  2003cited by this paper
• CCR1 is an early and specific marker of Alzheimer's disease

  2003influential reference
• Production and neuroprotective functions of fractalkine in the central nervous system.

  2003cited by this paper
• Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis

  2003influential reference
• Amyloid-β-induced chemokine production in primary human macrophages and astrocytes

  2002cited by this paper
• Up-regulation of FPR2, a chemotactic receptor for amyloid beta 1-42 (A beta 42), in murine microglial cells by TNF alpha.

  2002cited by this paper
• Bacterial Lipopolysaccharide Selectively Up-Regulates the Function of the Chemotactic Peptide Receptor Formyl Peptide Receptor 2 in Murine Microglial Cells1

  2002cited by this paper
• GROalpha/KC, a chemokine receptor CXCR2 ligand, can be a potent trigger for neuronal ERK1/2 and PI-3 kinase pathways and for tau hyperphosphorylation-a role in Alzheimer's disease?

  2002cited by this paper
• Fractalkine and fractalkine receptors in human neurons and glial cells

  2002influential reference
• Noradrenergic Depletion Potentiates β-Amyloid-Induced Cortical Inflammation: Implications for Alzheimer's Disease

  2002cited by this paper
• Manipulating chemoattractant and receptor genes.

  2002cited by this paper
• Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1.

  2001influential reference
• Inflammatory factors are elevated in brain microvessels in Alzheimer's disease.

  2001cited by this paper
• Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages.

  2001cited by this paper
• Amyloid-β Induces Chemotaxis and Oxidant Stress by Acting at Formylpeptide Receptor 2, a G Protein-coupled Receptor Expressed in Phagocytes and Brain*

  2001cited by this paper
• CXCR3 expression in human central nervous system diseases

  2001cited by this paper
• Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro

  2001cited by this paper
• Aging and proinflammatory cytokines

  2001cited by this paper
• Gene expression profiling of amyloid beta peptide-stimulated human post-mortem brain microglia.

  2001influential reference
• A burgeoning family of biological mediators: chemokines and chemokine receptors.

  2000cited by this paper
• Neuroprotective activity of chemokines against N-methyl-D-aspartate or beta-amyloid-induced toxicity in culture.

  2000influential reference
• Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer's disease.

  2000cited by this paper
• A central role for astrocytes in the inflammatory response to beta-amyloid; chemokines, cytokines and reactive oxygen species are produced.

  1999cited by this paper
• A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression.

  1999cited by this paper
• Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with beta-amyloid[25-35].

  1999cited by this paper
• Amyloid-β Induces Chemokine Secretion and Monocyte Migration across a Human Blood-Brain Barrier Model

  1998cited by this paper
• Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains.

  1998influential reference
• A new class of membrane-bound chemokine with a CX3C motif

  1997cited by this paper
• Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation

  1997influential reference
• Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease.

  1997cited by this paper
• Identification of monocyte chemoattractant protein‐1 in senile plaques and reactive microglia of Alzheimer's disease

  1997cited by this paper
• Nitric oxide synthase activity is elevated in brain microvessels in Alzheimer's disease.

  1994cited by this paper
• NEURONAL DEGENERATION IN LOCUS CERULEUS AND CORTICAL CORRELATES OF ALZHEIMER DISEASE

  1987cited by this paper
• Loss of nerve cells from locus coeruleus in Alzheimer's disease is topographically arranged.

  1986cited by this paper

• B Lymphocytes in Alzheimer’s Disease—A Comprehensive Review

  2022cites this paper
• New Insights on Formyl Peptide Receptor Type 2 Involvement in Nociceptive Processes in the Spinal Cord

  2022cites this paper
• The Role of Melatonin on Behavioral Changes and Concomitant Oxidative Stress in icvAβ1-42 Rat Model with Pinealectomy

  2021cites this paper
• Differential chemokine expression under the control of peripheral blood mononuclear cells issued from Alzheimer’s patients in a human blood brain barrier model

  2018cites this paper
• Longitudinal chemokine profile expression in a blood-brain barrier model from Alzheimer transgenic versus wild-type mice

  2018cites this paper
• Inflammation in Alzheimer’s Disease and Molecular Genetics: Recent Update

  2015cites this paper
• The Potential Role of Chemokines in Alzheimer’s Disease Pathogenesis

  2014cites this paper
• Neuroinflammation and β Amyloid Deposition in Alzheimer's Disease: In vivo Quantification with Molecular Imaging

  2013cites this paper