SCIENCE@home

Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

D. Kov,Aneta Mal,Jitka Mlźochov,M. Kalina,Zdenka Fohlerov,Antonín Hlav,žek,Zdenźk Farka,Petr Skl,Dal,Zenon Starźuk,Radovan Jiźík,Ondźej Slabý,J. Hub

Published 2017 in Journal of Nanomaterials

ABSTRACT

Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. The citrate-stabilised particles were produced with a narrow average size range below 2źnm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI) was then evaluated. The relaxivities (r1,r2) and r2/r1 ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T2-contrast probe.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-37 of 37 references · Page 1 of 1

CITED BY

Showing 1-33 of 33 citing papers · Page 1 of 1