Curcumin Inhibition of the Functional Interaction between Integrin α6β4 and the Epidermal Growth Factor Receptor

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Molecular Cancer Therapeutics

• Publication date

  2011-03-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1535-7163.MCT-10-1053PMID 21388972
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structural basis of the interaction between integrin α6β4 and plectin at the hemidesmosomes

  2009cited by this paper
• Alpha6beta4 integrin crosslinking induces EGFR clustering and promotes EGF-mediated Rho activation in breast cancer

  2009cited by this paper
• Phosphorylation of a novel site on the {beta}4 integrin at the trailing edge of migrating cells promotes hemidesmosome disassembly.

  2009cited by this paper
• Epidermal growth factor receptor inhibitors in cancer treatment: advances, challenges and opportunities.

  2009cited by this paper
• Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism

  2008cited by this paper
• Curcumin Inhibition of Integrin (α6β4)-Dependent Breast Cancer Cell Motility and Invasion

  2008cited by this paper
• Dissecting lipid raft facilitated cell signaling pathways in cancer.

  2008cited by this paper
• Curcumin: Preventive and Therapeutic Properties in Laboratory Studies and Clinical Trials

  2008cited by this paper
• A key tyrosine (Y1494) in the beta4 integrin regulates multiple signaling pathways important for tumor development and progression.

  2008cited by this paper
• Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

  2008cited by this paper
• Lipid Rafts and Caveolae in Signaling by Growth Factor Receptors

  2007cited by this paper
• The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARγ in rat activated hepatic stellate cell in vitro

  2007cited by this paper
• Serine phosphorylation of the integrin beta4 subunit is necessary for epidermal growth factor receptor induced hemidesmosome disruption.

  2007cited by this paper
• Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1

  2006influential reference
• p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration

  2006cited by this paper
• A simplified method for the preparation of detergent-free lipid rafts Published, JLR Papers in Press, February 16, 2005. DOI 10.1194/jlr.D400041-JLR200

  2005cited by this paper
• Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression.

  2005cited by this paper
• Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling.

  2004cited by this paper
• Protein Kinase C- (cid:2) Phosphorylation of Specific Serines in the Connecting Segment of the (cid:3) 4 Integrin Regulates the Dynamics of Type II Hemidesmosomes

  2004cited by this paper
• Adhesion-independent alpha6beta4 integrin clustering is mediated by phosphatidylinositol 3-kinase.

  2004cited by this paper
• Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor‐κB signaling

  2004cited by this paper
• Adhesion-Independent α6β4 Integrin Clustering Is Mediated by Phosphatidylinositol 3-Kinase

  2004cited by this paper
• Compartmentalization of integrin α6β4 signaling in lipid rafts

  2003cited by this paper
• Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells 1

  2003cited by this paper
• Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way.

  2003cited by this paper
• Epidermal growth factor receptor: mechanisms of activation and signalling.

  2003cited by this paper
• Inhibition of cell survival signal protein kinase B/Akt by curcumin in human prostate cancer cells

  2003cited by this paper
• Epidermal growth factor receptor: mechanisms of activation and signalling.

  2003cited by this paper
• Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells.

  2003cited by this paper
• Autocrine laminin-5 ligates 6 4 integrin and activates RAC and NF B to mediate anchorage-independent survival of mammary tumors

  2003cited by this paper
• Cell Migration: Integrating Signals from Front to Back

  2003cited by this paper
• Integrin (α6β4) regulation of eIF-4E activity and VEGF translation

  2002cited by this paper
• Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells.

  2002cited by this paper
• EGF-R signaling through Fyn kinase disrupts the function of integrin α6β4 at hemidesmosomes

  2001cited by this paper
• The alpha 6 beta 4 integrin and epithelial cell migration.

  2001cited by this paper
• The α6β4 integrin and epithelial cell migration

  2001cited by this paper
• Lipid rafts and signal transduction

  2000cited by this paper
• Cooperative Signaling between α6β4Integrin and ErbB-2 Receptor Is Required to Promote Phosphatidylinositol 3-Kinase-dependent Invasion*

  2000cited by this paper
• Structure and function of hemidesmosomes: more than simple adhesion complexes.

  1999cited by this paper
• Chemoprevention by curcumin during the promotion stage of tumorigenesis of mammary gland in rats irradiated with gamma-rays.

  1999cited by this paper
• Protein Kinase C–Dependent Mobilization of the α6β4 Integrin from Hemidesmosomes and Its Association with Actin-Rich Cell Protrusions Drive the Chemotactic Migration of Carcinoma Cells

  1999influential reference
• The intracellular functions of alpha6beta4 integrin are regulated by EGF

  1996cited by this paper
• Controlling Epidermal Growth Factor (EGF)-stimulated Ras Activation in Intact Cells by a Cell-permeable Peptide Mimicking Phosphorylated EGF Receptor*

  1996cited by this paper

• Cancer-specific cytotoxicity of curcumin through regulation of integrin β1 expression in colon cancer

  2025cites this paper
• Diet therapy abates mutant APC and KRas effects by reshaping plasma membrane cholesterol nanodomains.

  2024cites this paper
• Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK.

  2024cites this paper
• Anticancer Properties of Different Varieties of Date Palm (Phoenix dactylifera L.) Leaf Extracts in Human Tumor Cells: a Comparative Study

  2024cites this paper
• Targeting receptor tyrosine kinase signaling: Avenues in the management of cutaneous squamous cell carcinoma

  2023cites this paper
• Prospects of Curcumin Nanoformulations in Cancer Management

  2022cites this paper
• Neuroprotective Activities of Curcumin in Parkinson’s Disease: A Review of the Literature

  2021cites this paper
• How Effective is Curcumin in Prevention of Cancer

  2021cites this paper
• Treating Carcinomas through Integrin α6β4 Modification and Inhibition

  2021cites this paper
• Roles of Membrane Domains in Integrin-Mediated Cell Adhesion

  2020cites this paper
• Crosstalk between Epidermal Growth Factor Receptors (EGFR) and integrins in resistance to EGFR tyrosine kinase inhibitors (TKIs) in solid tumors.

  2020cites this paper
• Vascular endothelial growth factor: An important molecular target of curcumin

  2019cites this paper
• The Role of Human α7-Nicotinic Acetylcholine Receptors in Mediating Neuroprotective Action of Curcumin

  2018cites this paper
• Molecular Mechanisms of Breast Cancer Metastasis and Potential Anti-metastatic Compounds.

  2018cites this paper
• Curcumin modulates endothelial permeability and monocyte transendothelial migration by affecting endothelial cell dynamics.

  2017cites this paper
• Curcumin mediates anticancer effects by modulating multiple cell signaling pathways.

  2017cites this paper
• Phytotherapy and Nutritional Supplements on Breast Cancer

  2017cites this paper
• Progress toward Understanding Protein S-acylation: Prospective in Plants

  2017cites this paper
• Emerging role of chemoprotective agents in the dynamic shaping of plasma membrane organization.

  2017cites this paper
• Diverse Roles of Protein S-acyl Transferases in Arabidopsis thaliana

  2016cites this paper
• Rapidly cycling Lgr5+ stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk

  2016cites this paper
• Chemoprevention of Breast Cancer by Dietary Polyphenols

  2015cites this paper
• Clinical significance of the integrin α6β4 in human malignancies

  2015cites this paper
• Therapeutic targeting of replicative immortality

  2015cites this paper
• Curcumin Prevents Palmitoylation of Integrin β4 in Breast Cancer Cells

  2015cites this paper
• Dissecting the Role of Curcumin in Tumour Growth and Angiogenesis in Mouse Model of Human Breast Cancer

  2015cites this paper
• EGFR Inhibition by Curcumin in Cancer Cells: A Dual Mode of Action.

  2015cites this paper
• Targeting epidermal growth factor receptors and downstream signaling pathways in cancer by phytochemicals

  2015cites this paper
• The Multifaceted Role of Curcumin in Cancer Prevention and Treatment

  2015cites this paper
• CLINICAL AND PATHOLOGIC SIGNIFICANCE OF INTEGRIN α6β4 EXPRESSION IN HUMAN MALIGNANCIES

  2015cites this paper
• Phytochemicals and Cancer – Possible Molecular Targets of Phytochemicals in Cancer Prevention and Therapy

  2015cites this paper
• The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

  2014influential citation
• Curcumin Enhances Docetaxel-Induced Apoptosis of 8505C Anaplastic Thyroid Carcinoma Cells

  2014cites this paper
• Review on the contribution of Ura-Marunnu, a traditional baby care practice in southern India

  2014cites this paper
• Bcl-2 family proteins and cytoskeleton changes involved in DM-1 cytotoxic effect on melanoma cells

  2013cites this paper
• The Effect of Curcumin on Breast Cancer Cells

  2013cites this paper
• Potential Therapeutic Molecular Targets for Nasopharyngeal Carcinoma

  2012cites this paper
• Curcumin and its formulations: potential anti-cancer agents.

  2012cites this paper
• Chemopreventive and chemotherapeutic potential of curcumin in breast cancer.

  2012cites this paper
• Polyphenols as Receptor Tyrosine Kinase Inhibitors and Anti-cancer Agents

  2012cites this paper
• Critical role of plectin in anti-migration potential of curcumin

  2011cites this paper
• Pharmacological and clinical properties of curcumin

  2011cites this paper
• N-Glycosylation of ß4 Integrin Controls the Adhesion and Motility of Keratinocytes

  2011cites this paper
• Progress towards Understanding Protein S-acylation : Prospective in Plants 1 2

  year unknowncites this paper
• Deficiency of G-protein coupled receptor 40, a lipid-activated receptor, heightens in vitro-and in vivo-induced murine osteoarthritis

  year unknowncites this paper