Cytotoxicity of Clostridium difficile toxin B does not require cysteine protease-mediated autocleavage and release of the glucosyltransferase domain into the host cell cytosol.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Pathogens and Disease

• Publication date

  2013-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/2049-632X.12016PMID 23620115PMCID PMC3742912
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TcdB from hypervirulent Clostridium difficile exhibits increased efficiency of autoprocessing

  2012cited by this paper
• A Chimeric Toxin Vaccine Protects against Primary and Recurrent Clostridium difficile Infection

  2012cited by this paper
• Autoproteolytic cleavage mediates cytotoxicity of Clostridium difficile toxin A

  2011cited by this paper
• Host S-nitrosylation inhibits clostridial small molecule–activated glucosylating toxins

  2011influential reference
• Super toxins from a super bug: structure and function of Clostridium difficile toxins.

  2011cited by this paper
• Four distinct structural domains in Clostridium difficile toxin B visualized using SAXS.

  2010cited by this paper
• Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins

  2010cited by this paper
• Variations in TcdB Activity and the Hypervirulence of Emerging Strains of Clostridium difficile

  2010cited by this paper
• Structural organization of the functional domains of Clostridium difficile toxins A and B

  2010cited by this paper
• The role of toxin A and toxin B in Clostridium difficile infection

  2010cited by this paper
• Antibody-Enhanced, Fc Gamma Receptor-Mediated Endocytosis of Clostridium difficile Toxin A

  2009cited by this paper
• Autocatalytic Processing of Clostridium difficile Toxin B

  2009cited by this paper
• Structure-Function Analysis of Inositol Hexakisphosphate-induced Autoprocessing in Clostridium difficile Toxin A*

  2009cited by this paper
• Toxin B is essential for virulence of Clostridium difficile

  2009cited by this paper
• Clostridium difficile infection: new developments in epidemiology and pathogenesis

  2009cited by this paper
• Clostridium difficile–related Hospitalizations among US Adults, 2006

  2009cited by this paper
• BMC Microbiology BioMed Central Methodology article Detection of Balamuthia mandrillaris DNA by real-time PCR

  2008influential reference
• Comparative analysis of BI/NAP1/027 hypervirulent strains reveals novel toxin B-encoding gene (tcdB) sequences.

  2008cited by this paper
• Clostridium difficile--more difficult than ever.

  2008cited by this paper
• Clostridium difficile toxins: more than mere inhibitors of Rho proteins.

  2008cited by this paper
• Processing of Clostridium difficile toxins.

  2008cited by this paper
• Structure and mode of action of clostridial glucosylating toxins: the ABCD model.

  2008cited by this paper
• Autocatalytic cleavage of Clostridium difficile toxin B

  2007cited by this paper
• Clostridium difficile toxin A-induced apoptosis is p53-independent but depends on glucosylation of Rho GTPases

  2007cited by this paper
• Autoprocessing of the Vibrio cholerae RTX toxin by the cysteine protease domain

  2007cited by this paper
• Auto-catalytic Cleavage of Clostridium difficile Toxins A and B Depends on Cysteine Protease Activity*

  2007cited by this paper
• Cellular stability of Rho‐GTPases glucosylated by Clostridium difficile toxin B

  2006cited by this paper
• Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A.

  2005cited by this paper
• Characterization of the cleavage site and function of resulting cleavage fragments after limited proteolysis of Clostridium difficile toxin B (TcdB) by host cells.

  2005cited by this paper
• Clostridium difficile Toxins: Mechanism of Action and Role in Disease

  2005cited by this paper
• Cellular Uptake of Clostridium difficile Toxin B

  2003cited by this paper
• Clostridium difficile toxin B activates dual caspase‐dependent and caspase‐independent apoptosis in intoxicated cells

  2002cited by this paper
• Low pH-induced Formation of Ion Channels by Clostridium difficile Toxin B in Target Cells*

  2001cited by this paper
• pH-Induced Conformational Changes inClostridium difficile Toxin B

  2000cited by this paper
• Localization of the Glucosyltransferase Activity of Clostridium difficile Toxin B to the N-terminal Part of the Holotoxin*

  1997cited by this paper
• Glucosylation of Rho proteins by Clostridium difficile toxin B

  1995cited by this paper
• Mutagenesis of the Clostridium difficile toxin B gene and effect on cytotoxic activity.

  1994cited by this paper
• Evidence for a modular structure of the homologous repetitive C-terminal carbohydrate-binding sites of Clostridium difficile toxins and Streptococcus mutans glucosyltransferases

  1992cited by this paper

• Cysteine proteases and how YabG fits into clan CD of the MEROPS database

  2025cites this paper
• The anti-inflammatory and anti-apoptotic effects of Achillea millefolium L. extracts on Clostridioides difficile ribotype 001 in human intestinal epithelial cells

  2024cites this paper
• Development and characterization of phage display-derived anti-toxin antibodies neutralizing TcdA and TcdB of Clostridioides difficile

  2023cites this paper
• Structures of distant diphtheria toxin homologs reveal functional determinants of an evolutionarily conserved toxin scaffold

  2022cites this paper
• Curcumin and capsaicin regulate apoptosis and alleviate intestinal inflammation induced by Clostridioides difficile in vitro

  2022cites this paper
• Structures of distant diphtheria toxin homologs reveal functional determinants of an evolutionarily conserved toxin scaffold

  2022cites this paper
• Structure-function analysis of distant diphtheria toxin homologs reveals insights into host adaptation

  2021cites this paper
• Mode of action of a novel lymphocyte inhibitory factor of attaching and effacing Escherichia coli

  2020cites this paper
• Deletion of a 19-Amino-Acid Region in Clostridioides difficile TcdB2 Results in Spontaneous Autoprocessing and Reduced Cell Binding and Provides a Nontoxic Immunogen for Vaccination

  2019influential citation
• Cysteine Protease-Mediated Autocleavage of Clostridium difficile Toxins Regulates Their Proinflammatory Activity

  2018cites this paper
• Novel Chimeric Protein Vaccines Against Clostridium difficile Infection

  2018cites this paper
• Structure Function Studies of Large Clostridial Cytotoxins

  2017cites this paper
• Structure-Function Study of Large Clostridial Toxins and their Glucosyltransferase Domains

  2017cites this paper
• The role of purified Clostridium difficile glucosylating toxins in disease pathogenesis utilizing a murine cecum injection model.

  2017cites this paper
• The role of toxins in Clostridium difficile infection.

  2017cites this paper
• Chemical Strategies To Target Bacterial Virulence.

  2017cites this paper
• Bacterial Infections of the Small and Large Intestine

  2016cites this paper
• Pathogenic effects of glucosyltransferase from Clostridium difficile toxins.

  2016cites this paper
• Comment on “A small-molecule antivirulence agent for treating Clostridium difficile infection”

  2016cites this paper
• Defective mutations within the translocation domain of Clostridium difficile toxin B impair disease pathogenesis.

  2016cites this paper
• Response to Comment on “A small-molecule antivirulence agent for treating Clostridium difficile infection”

  2016cites this paper
• infection ' ' Clostridium difficile Comment on ' ' A small-molecule antivirulence agent for treating

  2016cites this paper
• Role of Clostridium difficile Toxins in Antibiotic-Associated Diarrhea and Pseudomembranous Colitis

  2016cites this paper
• Role of Clostridium Perfringens Alpha, Beta, Epsilon and Lota Toxins in Enterotoxemia of Monogastrics and Ruminants

  2016cites this paper
• Binding and entry of Clostridium difficile toxin B is mediated by multiple domains

  2015cites this paper
• Masking autoprocessing of Clostridium difficile toxin A by the C-terminus combined repetitive oligo peptides.

  2015cites this paper
• Distinct Roles of the Repeat-Containing Regions and Effector Domains of the Vibrio vulnificus Multifunctional-Autoprocessing Repeats-in-Toxin (MARTX) Toxin

  2015cites this paper
• Small Molecules Take A Big Step Against Clostridium difficile.

  2015cites this paper
• Small molecule inhibitors of Clostridium difficile toxin B-induced cellular damage.

  2015cites this paper
• A small-molecule antivirulence agent for treating Clostridium difficile infection

  2015cites this paper
• Exposure of Neutralizing Epitopes in the Carboxyl-terminal Domain of TcdB Is Altered by a Proximal Hypervariable Region*

  2015cites this paper
• Critical Roles of Clostridium difficile Toxin B Enzymatic Activities in Pathogenesis

  2014influential citation
• Molecular characterization of pathogenic Clostridium difficile strains

  2014cites this paper
• The role of local and systemic cytokines in patients infected with Clostridium difficile.

  2014cites this paper
• Mechanisms of Protection against Clostridium difficile Infection by the Monoclonal Antitoxin Antibodies Actoxumab and Bezlotoxumab

  2014cites this paper
• A novel approach to generate a recombinant toxoid vaccine against Clostridium difficile

  2013cites this paper
• Recent insights into Clostridium difficile pathogenesis

  2013cites this paper