Glutathione-S-Transferase as a selective inhibitor of oncogenic ras-p21-induced mitogenic signaling through blockade of activation of jun by jun-N-terminal kinase.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Annals of Clinical and Laboratory Science

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10678584
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of JNK signaling by GSTp

  1999cited by this paper
• Selective inhibition of oncogenic ras-p21 in vivo by agents that block its interaction with jun-N-kinase (JNK) and jun proteins. Implications for the design of selective chemotherapeutic agents

  1997cited by this paper
• Insulin stimulation of a MEK-dependent but ERK-independent SOS protein kinase

  1996cited by this paper
• Activation of c-Jun-NH2-Kinase by UV Irradiation Is Dependent on p21ras*

  1996cited by this paper
• Complexes of p21RAS with JUN N-terminal kinase and JUN proteins.

  1995cited by this paper
• JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.

  1994cited by this paper
• Evidence that oocyte maturation induced by an oncogenic ras-p21 protein and insulin is mediated by overlapping yet distinct mechanisms.

  1992cited by this paper
• Pathways for activation of the ras-oncogene-encoded p21 protein.

  1992cited by this paper
• Evidence that the ras oncogene-encoded p21 protein induces oocyte maturation via activation of protein kinase C.

  1992cited by this paper
• Monoclonal antibodies to glutathione S‐Transferase π–immunohistochemical analysis of human tissues and cancers

  1991cited by this paper
• A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and In vitro anti‐proliferative as well as In vivo anti‐tumor activity

  1989cited by this paper
• Glutathione transferases--structure and catalytic activity.

  1988cited by this paper
• Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes.

  1988cited by this paper
• Insulin induction of Xenopus laevis oocyte maturation is inhibited by monoclonal antibody against p21 ras proteins.

  1987cited by this paper
• ras genes.

  1987cited by this paper
• ras proteins can induce meiosis in Xenopus oocytes.

  1985cited by this paper
• Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family

  1982cited by this paper
• Purification of glutathione S-transferases from human liver by glutathione-affinity chromatography.

  1977cited by this paper
• Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.

  1974cited by this paper

• Towards the regulation of ASK-1 by ras activity in the mouse brain

  2016cites this paper
• Molecular Pathology and Diagnostics of Prostate Cancer

  2014cites this paper
• Selective induction of glutathione S-transferases in round spermatids from the Brown-Norway rat by the chemotherapeutic regimen for testicular cancer.

  2013cites this paper
• Thiazolide-induced apoptosis in colorectal cancer cells is mediated via the Jun kinase–Bim axis and reveals glutathione-S-transferase P1 as Achilles’ heel

  2012cites this paper
• Glutathione-S-Transferases in Development, Progression and Therapy of Colorectal Cancer

  2012cites this paper
• The role of a membrane-bound glutathione transferase in the peroxynitrite-induced mitochondrial permeability transition pore: formation of a disulfide-linked protein complex.

  2011cites this paper
• Kinases and glutathione transferases: selective and sensitive targeting

  2011cites this paper
• Regulation of the Glutathione S-Transferase P1 Expression in Melanoma Cells

  2011cites this paper
• Inhibition of mitochondrial membrane bound-glutathione transferase by mitochondrial permeability transition inhibitors including cyclosporin A.

  2010cites this paper
• Anti-Angiogenic Therapy Induces Integrin-Linked Kinase 1 Up-Regulation in a Mouse Model of Glioblastoma

  2010cites this paper
• Serum glutathione transferase does not respond to indole-3-carbinol: A pilot study

  2010cites this paper
• Serum glutathione transferase does not respond to indole-3-carbinol: A pilot study

  2010cites this paper
• Serum glutathione transferase does not respond to indole-3-carbinol: A pilot study

  2010cites this paper
• Mechanisms of tumor promotion by reactive oxygen species

  2010cites this paper
• Serum glutathione transferase does not respond to indole-3-carbinol: A pilot study

  2010cites this paper
• Serum glutathione transferase does not respond to indole-3-carbinol: A pilot study

  2010cites this paper
• Contribution of liver mitochondrial membrane-bound glutathione transferase to mitochondrial permeability transition pores.

  2009cites this paper
• Putative mechanisms of action for indole-3-carbinol in the prevention of colorectal cancer.

  2008cites this paper
• Two peptides derived from ras-p21 induce either phenotypic reversion or tumor cell necrosis of ras-transformed human cancer cells

  2008cites this paper
• Putative mechanisms of action for indole-3-carbinol in the prevention of colorectal cancer

  2008cites this paper
• Novel peptides from the RAS-p21 and p53 proteins for the treatment of cancer.

  2007cites this paper
• Involvement of glutathione/glutathione S‐transferase antioxidant system in butyrate‐inhibited vascular smooth muscle cell proliferation

  2007cites this paper
• Two dual specificity kinases are preferentially induced by wild-type rather than by oncogenic RAS-P21 in Xenopus oocytes.

  2006cites this paper
• Inhibition of Activator Protein-1, NF-κB, and MAPKs and Induction of Phase 2 Detoxifying Enzyme Activity by Chlorogenic Acid*

  2005cites this paper
• The chemistry and biology of inhibitors and pro-drugs targeted to glutathione S-transferases

  2005cites this paper
• The Human Glutathione S-Transferase P1 Protein Is Phosphorylated and Its Metabolic Function Enhanced by the Ser/Thr Protein Kinases, cAMP-Dependent Protein Kinase and Protein Kinase C, in Glioblastoma Cells

  2004cites this paper
• Effector peptides from glutathione-S-transferase-pi affect the activation of jun by jun-N-terminal kinase.

  2004cites this paper
• Development of new anti-cancer peptides from conformational energy analysis of the oncogenic ras-p21 protein and its complexes with target proteins.

  2004cites this paper
• Neural-specific overexpression of Drosophila Plenty of SH3s (DPOSH) extends the longevity of adult flies

  2004cites this paper
• The JNK binding domain of islet-brain 1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines.

  2003cites this paper
• Detoxification of electrophilic compounds by glutathione S‐transferase catalysis: Determinants of individual response to chemical carcinogens and chemotherapeutic drugs?

  2003cites this paper
• Ras-MAP Kinase Signaling Pathways and Control of Cell Proliferation: Relevance to Cancer Therapy

  2002cites this paper
• Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress.

  2002cites this paper
• Increased risk for therapy-associated hematologic malignancies in patients with carcinoma of the breast and combined homozygous gene deletions of glutathione transferases M1 and T1.

  2002cites this paper
• GLUTATHIONE CONJUGATES AND THEIR SYNTHETIC DERIVATIVES AS INHIBITORS OF GLUTATHIONE-DEPENDENT ENZYMES INVOLVED IN CANCER AND DRUG RESISTANCE

  2002cites this paper
• Longevity determination genes in Drosophila melanogaster.

  2002cites this paper
• Peroxynitrite activates NF-E2-related factor 2/antioxidant response element through the pathway of phosphatidylinositol 3-kinase: the role of nitric oxide synthase in rat glutathione S-transferase A2 induction.

  2002cites this paper
• A protein kinase C inhibitor induces phenotypic reversion of ras-transformed pancreatic cancer cells and cooperatively blocks tumor cell proliferation with an anti-ras peptide

  2002cites this paper
• Differences in patterns of activation of MAP kinases induced by oncogenic ras-p21 and insulin in oocytes.

  2001cites this paper
• Activation of phosphatidylinositol 3-kinase and Akt by tert-butylhydroquinone is responsible for antioxidant response element-mediated rGSTA2 induction in H4IIE cells.

  2001cites this paper
• The Gene Search System: Its Application to Functional Genomics in Drosophila Melanogaster

  2001cites this paper
• The role of glutathione S-transferase P1-1 in colorectal cancer: friend or foe?

  2001cites this paper
• The Glutathione Transferase Structural Family Includes a Nuclear Chloride Channel and a Ryanodine Receptor Calcium Release Channel Modulator*

  2001cites this paper
• Induction of oocyte maturation by jun-N-terminal kinase (JNK) on the oncogenic ras-p21 pathway is dependent on the raf-MEK signal transduction pathway.

  2000cites this paper
• Induction of oocyte maturation by jun-N-terminal kinase (JNK) on the oncogenic ras-p21 pathway is dependent on the raf-MEK-MAP kinase signal transduction pathway

  2000cites this paper
• Identification, Using Molecular Dynamics, of an Effector Domain of the ras-Binding Domain of the raf-p74 Protein That Is Uniquely Involved in Oncogenic ras-p21 Signaling

  2000cites this paper
• Identification of a Glutathione-S-Transferase Effector Domain for Inhibition of jun Kinase, by Molecular Dynamics

  1999cites this paper