Amyloid-β induced astrocytosis and astrocyte death: Implication of FoxO3a-Bim-caspase3 death signaling.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Molecular and cellular neurosciences

• Publication date

  2015-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.mcn.2015.08.002PMID 26260111
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2012influential reference
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  2011influential reference
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  2010influential reference
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  2000influential reference
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  1995influential reference
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  1995cited by this paper
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  1991cited by this paper
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