Insulin causes airway hyper-reactivity

Background: We explored the acute effects of insulin and one possible mechanism underlying the acute contractile effects of insulin on isolated tracheal smooth muscle of guinea pig in vitro. Methods: Effects of increasing concentrations of histamine (10 −7 -10 −3 M), insulin (10 −7 -10 −3 M), insulin pretreated with a fixed concentration of indomethacin (10 −6 M) were studied on isolated tracheal tissue of guinea pig in vitro by constructing cumulative concentration response curves. The tracheal smooth muscle contractions were recorded with transducer on four channel oscillograph. Results: Histamine and insulin produced a concentration-dependent reversible contraction of isolated tracheal muscle of guinea pig. The mean±standard error of the mean of maximum amplitudes of contraction with histamine, insulin and insulin pretreated with indomethacin were 92.5±1.20 mm, 35±1.13 mm and 14.55±0.62 mm respectively. Indomethacin shifted the concentration-response curve of insulin to the right and downwards. Conclusions: Insulin has acute contractile effects on guinea pig airways, which were significantly inhibited by prostaglandin synthesis inhibitor indomethacin confirming the involvement of contractile prostaglandins in insulin-induced airway hyper-responsiveness.

• Publication year

  2014

• Venue

  International journal of basic and clinical pharmacology

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.5455/2319-2003.IJBCP20141001
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Insulin Lung Deposition and Clearance Following Technosphere® Insulin Inhalation Powder Administration

  2011cited by this paper
• Anti-asthmatic and Anti-allergic effects of Thymoquinone on Airway-Induced Hypersensitivity in Experimental Animals

  2011cited by this paper
• Treatment of Type 1 and Type 2 Diabetes Mellitus with Insulin Detemir, a Long-Acting Insulin Analog

  2010cited by this paper
• Functional consequences of human airway smooth muscle phenotype plasticity

  2010cited by this paper
• Effect of Insulin on Airway Responsiveness in Patients with Type 2 Diabetes Mellitus: A Cohort Study

  2009cited by this paper
• Insulin-induced laminin expression promotes a hypercontractile airway smooth muscle phenotype.

  2009cited by this paper
• Insulin induces airway smooth muscle contraction

  2007cited by this paper
• EVALUATION OF ANTIHISTAMINIC ACTIVITY OF PIPER BETEL LEAF IN GUINEA PIG

  2006cited by this paper
• Lipopolysaccharide Induces Epithelium- and Prostaglandin E2-Dependent Relaxation of Mouse Isolated Trachea through Activation of Cyclooxygenase (COX)-1 and COX-2

  2006cited by this paper
• Mechanisms underlying the relaxation response induced by bradykinin in the epithelium‐intact guinea‐pig trachea in vitro

  2005cited by this paper
• Efficacy and safety of inhaled insulin (exubera) compared with subcutaneous insulin therapy in patients with type 2 diabetes: results of a 6-month, randomized, comparative trial.

  2004cited by this paper
• Down-regulation of mast cell activation and airway reactivity in diabetic rats: role of insulin

  2004cited by this paper
• Hyperresponsiveness to bronchoconstrictor agents in experimental animals treated with terbutaline and its effect on pancreatic beta cells.

  1995cited by this paper

• No citing papers are available for this paper.