Nrf2, not the estrogen receptor, mediates catechol estrogen-induced activation of the antioxidant responsive element.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Biochimica et Biophysica Acta

• Publication date

  2003-10-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/J.BBAEXP.2003.08.006PMID 14522084
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of the NF-E2-related Factor-2-dependent Genes Conferring Protection against Oxidative Stress in Primary Cortical Astrocytes Using Oligonucleotide Microarray Analysis*

  2003cited by this paper
• Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence.

  2003cited by this paper
• Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression*

  2003cited by this paper
• Increased Protein Stability as a Mechanism That Enhances Nrf2-mediated Transcriptional Activation of the Antioxidant Response Element

  2003cited by this paper
• Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

  2003cited by this paper
• Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.

  2002cited by this paper
• Activation of the antioxidant response element in primary cortical neuronal cultures derived from transgenic reporter mice

  2002cited by this paper
• Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

  2002cited by this paper
• Microarray Analysis Reveals an Antioxidant Responsive Element-driven Gene Set Involved in Conferring Protection from an Oxidative Stress-induced Apoptosis in IMR-32 Cells*

  2002cited by this paper
• Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription*

  2002cited by this paper
• Site-directed mutagenesis of cysteine to serine in the DNA binding regionof Nrf2 decreases its capacity to upregulate antioxidant responseelement-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

  2002cited by this paper
• Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

  2001cited by this paper
• Phosphatidylinositol 3-Kinase, Not Extracellular Signal-regulated Kinase, Regulates Activation of the Antioxidant-Responsive Element in IMR-32 Human Neuroblastoma Cells*

  2001cited by this paper
• Regulation of human apolipoprotein A-I gene expression by equine estrogens.

  2001cited by this paper
• Effect of two mutations of human CYP1B1, G61E and R469W, on stability and endogenous steroid substrate metabolism.

  2001cited by this paper
• Nrf2-dependent activation of the antioxidant responsive element by tert-butylhydroquinone is independent of oxidative stress in IMR-32 human neuroblastoma cells.

  2001cited by this paper
• Activation of phosphatidylinositol 3-kinase and Akt by tert-butylhydroquinone is responsible for antioxidant response element-mediated rGSTA2 induction in H4IIE cells.

  2001cited by this paper
• Inhibition of ERK and p38 MAP kinases inhibits binding of Nrf2 and induction of GCS genes.

  2000cited by this paper
• Identification and Characterization of a Novel Factor That Regulates Quinone Reductase Gene Transcriptional Activity*

  2000cited by this paper
• Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells. Role of p38 kinase and Nrf2 transcription factor.

  2000cited by this paper
• Activation of Mitogen-activated Protein Kinase Pathways Induces Antioxidant Response Element-mediated Gene Expression via a Nrf2-dependent Mechanism*

  2000cited by this paper
• The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties.

  1999cited by this paper
• Activation of antioxidant/electrophile-responsive elements in IMR-32 human neuroblastoma cells.

  1999cited by this paper
• Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.

  1999cited by this paper
• The Mitogen-Activated Protein Kinase Pathway Mediates Estrogen Neuroprotection after Glutamate Toxicity in Primary Cortical Neurons

  1999cited by this paper
• Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β.

  1998cited by this paper
• Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists.

  1998cited by this paper
• Transcriptional Regulation of the Human Quinone Reductase Gene by Antiestrogen-liganded Estrogen Receptor-α and Estrogen Receptor-β*

  1998cited by this paper
• Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.

  1998cited by this paper
• Transcriptional regulation of the human quinone reductase gene by antiestrogen-liganded estrogen receptor-alpha and estrogen receptor-beta.

  1998cited by this paper
• Differential Response of Estrogen Receptor α and Estrogen Receptor β to Partial Estrogen Agonists/Antagonists

  1998cited by this paper
• 17 alpha-estradiol exerts neuroprotective effects on SK-N-SH cells.

  1997cited by this paper
• Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites.

  1997cited by this paper
• The world according to Maf.

  1997cited by this paper
• 17α-Estradiol Exerts Neuroprotective Effects on SK-N-SH Cells

  1997cited by this paper
• The quinone reductase gene: a unique estrogen receptor-regulated gene that is activated by antiestrogens.

  1997cited by this paper
• NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development.

  1996cited by this paper
• 17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.

  1996cited by this paper
• Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens.

  1995cited by this paper
• Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

  1994cited by this paper
• Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer.

  1994cited by this paper
• Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells.

  1994cited by this paper
• The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity.

  1991cited by this paper
• Activation of the ovalbumin gene by the estrogen receptor involves the fos-jun complex.

  1990cited by this paper
• Identification of an estrogen response element upstream of the human c-fos gene that binds the estrogen receptor and the AP-1 transcription factor.

  1990cited by this paper
• Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

  1986cited by this paper

• Streptococcus thermophilus CNCM I-5570 lysate counteracts the aging process in human dermal fibroblast cells by neutralizing harmful free radicals and impacting antioxidant and anti-inflammatory pathways, thus restoring their physiological functions.

  2025cites this paper
• Efficacy of an Innovative Poly-Component Formulation in Counteracting Human Dermal Fibroblast Aging by Influencing Oxidative and Inflammatory Pathways

  2024cites this paper
• Apo-form of recombinant human lactoferrin changes the genome-wide DNA methylation level and the chromatin compaction degree in neuroblastoma cell line IMR-32

  2023cites this paper
• Tissue remodeling in adult vernal keratoconjunctivitis.

  2022cites this paper
• Triad role of hepcidin, ferroportin, and Nrf2 in cardiac iron metabolism: From health to disease.

  2021cites this paper
• Role of Sex Hormones and Their Receptors on Gastric Nrf2 and Neuronal Nitric Oxide Function in an Experimental Hyperglycemia Model

  2020cites this paper
• Molecular mechanisms involved in the protective actions of Selective Estrogen Receptor Modulators in brain cells.

  2019cites this paper
• Role of sex hormones and their receptors on gastric Nrf2 and neuronal nitric oxide synthase function in an experimental hyperglycemia model

  2019cites this paper
• Ketamine ameliorates oxidative stress-induced apoptosis in experimental traumatic brain injury via the Nrf2 pathway

  2018cites this paper
• Ketamine ameliorates oxidative stress-induced apoptosis in experimental traumatic brain injury via the nrf2 pathway

  2018cites this paper
• 4-Hydroxyestradiol induces mammary epithelial cell transformation through Nrf2-mediated heme oxygenase-1 overexpression

  2016cites this paper
• Molecular changes associated with chronic liver damage and neoplastic lesions in a murine model of hereditary tyrosinemia type 1.

  2015cites this paper
• Licochalcone A activates Nrf2 in vitro and contributes to licorice extract‐induced lowered cutaneous oxidative stress in vivo

  2015cites this paper
• Quinone Methide Bioactivation Pathway: Contribution to Toxicity and/or Cytoprotection?

  2014cites this paper
• Protective effects of apomorphine against zinc-induced neurotoxicity in cultured cortical neurons.

  2013cites this paper
• LOSS of Mrp1 alters detoxification enzyme expression in a tissue‐ and hormonal‐status‐specific manner

  2013cites this paper
• Chemopreventive activity of tocopherols in mammary tumorigenesis

  2013cites this paper
• Fumaric Acid Esters Stimulate Astrocytic VEGF Expression through HIF-1α and Nrf2

  2013cites this paper
• Cell Models for the Study of Sex Steroid Hormone Neurobiology.

  2012cites this paper
• Dietary Nrf2 activators inhibit atherogenic processes.

  2012cites this paper
• 17β‐Estradiol regulates the expression of antioxidant enzymes in myocardial cells by increasing Nrf2 translocation

  2012cites this paper
• TARGETING THE GENOTOXIC EFFECTS OF ESTROGENS.

  2012cites this paper
• Phytochemical metabolites and their effects on in vitro and in vivo measures of oxidative stress

  2011influential citation
• La Autoantigen Mediates Oxidant Induced De Novo Nrf2 Protein Translation*

  2011cites this paper
• Sulforaphane inhibits redox-regulated permeability transition and provides neuroprotection following cardiac arrest

  2011cites this paper
• Soy isoflavones increase quinone reductase in hepa-1c1c7 cells via estrogen receptor beta and nuclear factor erythroid 2-related factor 2 binding to the antioxidant response element.

  2011cites this paper
• Ginsenoside Rb1 protects against 6-hydroxydopamine-induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/Akt/Nrf2-dependent pathway in human dopaminergic cells.

  2010cites this paper
• 17-β estradiol protects ARPE-19 cells from oxidative stress through estrogen receptor-β.

  2010cites this paper
• Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones.

  2010cites this paper
• Neuroprotection after Cardiac Arrest by Avoiding Acute Hyperoxia and by Antioxidant Genomic Postconditioning

  2009cites this paper
• Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1.

  2009cites this paper
• Effect of dietary genistein on Phase II and antioxidant enzymes in rat liver.

  2009cites this paper
• Aromatase: the enzyme and its inhibition.

  2009cites this paper
• Phytoestrogens modulate the expression of 17alpha-estradiol metabolizing enzymes in cultured MCF-7 cells.

  2008cites this paper
• Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1.

  2008influential citation
• The role of Nrf2 in increased reactive oxygen species and DNA damage in prostate tumorigenesis

  2008influential citation
• Potential mechanisms of estrogen quinone carcinogenesis.

  2008cites this paper
• Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1.

  2008cites this paper
• Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells.

  2008cites this paper
• Cardiovascular targets for estrogens and phytoestrogens: transcriptional regulation of nitric oxide synthase and antioxidant defense genes.

  2007cites this paper
• Protein-bound 3,4-dihydroxy-phenylanine (DOPA), a redox-active product of protein oxidation, as a trigger for antioxidant defences.

  2007cites this paper
• Insulin induces heme oxygenase‐1 through the phosphatidylinositol 3‐kinase/Akt pathway and the Nrf2 transcription factor in renal cells

  2006cites this paper
• CYP1A in TCDD Toxicity and in Physiology–with Particular Reference to CYP Dependent Arachidonic Acid Metabolism and other Endogenous Substrates

  2006cites this paper
• Phase II antioxidant enzyme activities in brain of male and female ACI rats treated chronically with estradiol.

  2006cites this paper
• Inhibitory actions of Ah receptor agonists and indole-containing compounds in breast cancer cell lines and mouse models

  2005cites this paper
• Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.

  2005cites this paper
• Specific binding of 4-hydroxyestradiol to mouse uterine protein: evidence of a physiological role for 4-hydroxyestradiol.

  2005cites this paper
• Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors.

  2004cites this paper
• Dietary clofibrate inhibits induction of hepatic antioxidant enzymes by chronic estradiol in female ACI rats.

  2004cites this paper
• In vitro and in vivo regulation of antioxidant response element-dependent gene expression by estrogens.

  2004cites this paper