Effects of intranasal oxytocin on tactile perception.

In addition to its role in childbirth labor and lactation, oxytocin is a well-known neurohormone, having several prosocial effects. Moreover, oxytocin seems to play a significant modulatory role in painful experiences, due to its participation in central and peripheral processing of nociceptive somatosensory information. Despite studies on oxytocin in pain modulation, there is a scarce literature investigating the role of oxytocin in tactile perception. Here we investigate the effects of 24 and 40 IU intranasal administration of oxytocin in the non-harmful mechanical tactile detection threshold in men. The data showed a significant increase in tactile perception in an experimental 40 IU oxytocin group. We suggest that this effect could be the basis for the oxytocin-bonding effect via touch.

• Publication year

  2019

• Venue

  Neuroscience Letters

• Publication date

  2019-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.neulet.2018.12.032PMID 30582971
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Oxytocin Receptor: From Intracellular Signaling to Behavior.

  2018cited by this paper
• Timing Mechanisms Underlying Gate Control by Feedforward Inhibition.

  2018cited by this paper
• Plasma Oxytocin in Children with Autism and Its Correlations with Behavioral Parameters in Children and Parents

  2016cited by this paper
• Oxytocin receptor: Expression in the trigeminal nociceptive system and potential role in the treatment of headache disorders

  2016cited by this paper
• The Social Salience Hypothesis of Oxytocin.

  2016cited by this paper
• Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation

  2015cited by this paper
• Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model.

  2015cited by this paper
• Activation of hypothalamic oxytocin neurons following tactile stimuli in rats.

  2015cited by this paper
• Effects of Intranasal Oxytocin on Thermal Pain in Healthy Men: A Randomized Functional Magnetic Resonance Imaging Study

  2015cited by this paper
• Constructing and deconstructing the gate theory of pain.

  2014cited by this paper
• The neuroanatomical distribution of oxytocin receptor binding and mRNA in the male rhesus macaque (Macaca mulatta).

  2014cited by this paper
• Impaired tactile processing in children with autism spectrum disorder.

  2014cited by this paper
• The Effect of Intranasal Oxytocin Administration on Acute Cold Pressor Pain: A Placebo-Controlled, Double-Blind, Within-Participants Crossover Investigation

  2014cited by this paper
• Transmitting pain and itch messages: a contemporary view of the spinal cord circuits that generate gate control.

  2014cited by this paper
• Discriminative and affective touch: sensing and feeling.

  2014cited by this paper
• Identification of oxytocin receptor in the dorsal horn and nociceptive dorsal root ganglion neurons.

  2013cited by this paper
• Immunohistochemical localization of oxytocin receptors in human brain.

  2013cited by this paper
• The interaction between the oxytocin and pain modulation in headache patients.

  2013cited by this paper
• The role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences.

  2013cited by this paper
• Neuromodulation by oxytocin and vasopressin.

  2012cited by this paper
• Massage increases oxytocin and reduces adrenocorticotropin hormone in humans.

  2012cited by this paper
• Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial

  2012cited by this paper
• Oxytocin in the rat caudate nucleus influences pain modulation.

  2011cited by this paper
• Oxytocin Receptor Gene Associated with the Efficiency of Social Auditory Processing

  2011cited by this paper
• Plasma oxytocin is related to lower cardiovascular and sympathetic reactivity to stress.

  2011cited by this paper
• Oxytocin, dopamine, and the amygdala: a neurofunctional model of social cognitive deficits in schizophrenia.

  2011cited by this paper
• Oxytocin in the periaqueductal gray participates in pain modulation in the rat by influencing endogenous opiate peptides.

  2011cited by this paper
• Oxytocin in the periaqueductal grey regulates nociception in the rat.

  2011cited by this paper
• The social role of touch in humans and primates: behavioural function and neurobiological mechanisms.

  2010cited by this paper
• Promoting social behavior with oxytocin in high-functioning autism spectrum disorders

  2010cited by this paper
• Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans

  2010cited by this paper
• Touch and the body: The role of the somatosensory cortex in tactile awareness

  2010cited by this paper
• Oxytocin-dopamine interactions mediate variations in maternal behavior in the rat.

  2010cited by this paper
• REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy

  2010cited by this paper
• Oxytocin: the great facilitator of life.

  2009cited by this paper
• Early contact versus separation: effects on mother-infant interaction one year later.

  2009cited by this paper
• Antinociceptive action of oxytocin involves inhibition of potassium channel currents in lamina II neurons of the rat spinal cord

  2009cited by this paper
• Defective oxytocin function: a clue to understanding the cause of autism?

  2009cited by this paper
• PRIORITY COMMUNICATION-BRIEF REPORT Oxytocin Increases Gaze to the Eye Region of Human Faces

  2008cited by this paper
• Ethnicity is associated with alterations in oxytocin relationships to pain sensitivity in women

  2008cited by this paper
• Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism.

  2007cited by this paper
• Oxytocin attenuates amygdala responses to emotional faces regardless of valence.

  2007cited by this paper
• Central oxytocin enhances antinociception in the rat.

  2007cited by this paper
• Usefulness and limitations of quantitative sensory testing: clinical and research application in neuropathic pain states.

  2007cited by this paper
• Oxytocin increases retention of social cognition in autism.

  2007cited by this paper
• Oxytocin actions on afferent evoked spinal cord neuronal activities in neuropathic but not in normal rats.

  2005cited by this paper
• Selective amnesic effects of oxytocin on human memory.

  2004cited by this paper
• Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress.

  2003cited by this paper
• Postpartum maternal oxytocin release by newborns: effects of infant hand massage and sucking.

  2001cited by this paper
• Quantitative sensory testing, neurophysiological and psychological examination in patients with complex regional pain syndrome and hemisensory deficits

  2001cited by this paper
• Postnatal Oxytocin Injections Cause Sustained Weight Gain and Increased Nociceptive Thresholds in Male and Female Rats

  1998cited by this paper
• Oxytocin may mediate the benefits of positive social interaction and emotions.

  1998cited by this paper
• OXYTOCIN MAY MEDIATE THE BENEFITS OF POSITIVE SOCIAL INTERACTION AND EMOTIONS 1 The purpose of this

  1998cited by this paper
• Oxytocin increases thresholds of colonic visceral perception in patients with irritable bowel syndrome.

  1996cited by this paper
• Intrathecal Administration of Oxytocin Induces Analgesia in Low Back Pain Involving the Endogenous Opiate Peptide System

  1994cited by this paper
• Intrathecal administration of oxytocin induces analgesia in low back pain involving the endogenous opiate peptide system.

  1994cited by this paper
• Oxytocin increases and a specific oxytocin antagonist decreases pain threshold in male rats.

  1992cited by this paper
• Pain mechanisms: a new theory.

  1965cited by this paper
• Cellular Neuroscience

  year unknowncited by this paper

• Intranasal Oxytocin and Physical Intimacy for Dermatological Wound Healing and Neuroendocrine Stress

  2025cites this paper
• Social dysfunction in autism spectrum disorder: Tactility and oxytocin

  2023cites this paper
• Does losing money truly hurt? The shared neural bases of monetary loss and pain

  2022cites this paper
• The Challenges and Perspectives of the Integration Between Virtual and Augmented Reality and Manual Therapies

  2021cites this paper
• Biofeedback – wahrnehmen und beeinflussen

  2021cites this paper
• Perceived pleasantness of gentle touch in healthy individuals is related to salivary oxytocin response and EEG markers of arousal

  2020cites this paper