Synthesis of 5- and 6-Carboxy-X-rhodamines

An efficient route is reported to 5- and 6-carboxy-X-rhodamines (compounds 1 and 2) that contain multiple n-propylene or γ,γ-dimethylpropylene groups bridging terminal nitrogen atoms and the central xanthene core. Gram quantities of these dyes are synthesized from inexpensive starting materials. The isolated products are activated by selective transformation of the carboxylic acid group into N-hydroxysuccinimidyl esters in situ and then conjugated with an amino group of a molecule of interest.

• Publication year

  2008

• Venue

  Organic Letters

• Publication date

  2008-10-07

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/ol801904kPMID 18837556PMCID 2646678
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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