Cell-based therapy for traumatic brain injury.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  British Journal of Anaesthesia

• Publication date

  2015-08-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1093/bja/aev229PMID 26170348PMCID PMC4500763
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition

  2016cited by this paper
• Neuroprotection for traumatic brain injury.

  2015cited by this paper
• Differentiation of Human Adipose-Derived Stem Cells into Neuron-Like Cells Which Are Compatible with Photocurable Three-Dimensional Scaffolds

  2014cited by this paper
• Immunosuppression does not affect human bone marrow mesenchymal stromal cell efficacy after transplantation in traumatized mice brain.

  2014cited by this paper
• Cell-based Therapy for Acute Organ Injury: Preclinical Evidence and Ongoing Clinical Trials Using Mesenchymal Stem Cells

  2014cited by this paper
• Basic fibroblast growth factor increases the transplantation‑mediated therapeutic effect of bone mesenchymal stem cells following traumatic brain injury.

  2014cited by this paper
• Mannitol enhances therapeutic effects of intra-arterial transplantation of mesenchymal stem cells into the brain after traumatic brain injury.

  2013cited by this paper
• Effects of Magnetically Labeled Exogenous Endothelial Progenitor Cells on Cerebral Blood Perfusion and Microvasculature Alterations after Traumatic Brain Injury in Rat Model

  2013cited by this paper
• Transplantation of mesenchymal stem cells to the brain by topical application in an experimental traumatic brain injury model.

  2013cited by this paper
• Stem Cell Recruitment of Newly Formed Host Cells via a Successful Seduction? Filling the Gap between Neurogenic Niche and Injured Brain Site

  2013cited by this paper
• Autologous bone marrow mesenchymal stem cell therapy in the subacute stage of traumatic brain injury by lumbar puncture.

  2013cited by this paper
• Hypoxic preconditioning enhances the therapeutic potential of the secretome from cultured human mesenchymal stem cells in experimental traumatic brain injury.

  2013cited by this paper
• Neural Stem-Like Cells Derived from Human Amnion Tissue are Effective in Treating Traumatic Brain Injury in Rat

  2013cited by this paper
• Protective Effects of BDNF Overexpression Bone Marrow Stromal Cell Transplantation in Rat Models of Traumatic Brain Injury

  2013cited by this paper
• The Role of Markers of Inflammation in Traumatic Brain Injury

  2013cited by this paper
• Transplantation of human mesenchymal stem cells loaded on collagen scaffolds for the treatment of traumatic brain injury in rats.

  2013cited by this paper
• Intravenous Multipotent Adult Progenitor Cell Therapy Attenuates Activated Microglial/Macrophage Response and Improves Spatial Learning After Traumatic Brain Injury

  2013cited by this paper
• Intravenous multipotent adult progenitor cell therapy after traumatic brain injury: modulation of the resident microglia population

  2012cited by this paper
• Safety of Cell Therapy with Mesenchymal Stromal Cells (SafeCell): A Systematic Review and Meta-Analysis of Clinical Trials

  2012cited by this paper
• Mesenchymal Stem Cells Regulate Blood-Brain Barrier Integrity Through TIMP3 Release After Traumatic Brain Injury

  2012cited by this paper
• Implantation of a collagen scaffold seeded with adult rat hippocampal progenitors in a rat model of penetrating brain injury.

  2012cited by this paper
• Combination of Temperature-Sensitive Stem Cells and Mild Hypothermia: A New Potential Therapy for Severe Traumatic Brain Injury

  2012cited by this paper
• Molecular Mechanisms Underlying Effects of Neural Stem Cells against Traumatic Axonal Injury

  2012cited by this paper
• Bench to Bedside of Neural Stem Cell in Traumatic Brain Injury

  2012cited by this paper
• Early distribution of intravenously injected mesenchymal stem cells in rats with acute brain trauma evaluated by (99m)Tc-HMPAO labeling.

  2011cited by this paper
• Long-Term Benefit of Human Fetal Neuronal Progenitor Cell Transplantation in a Clinically Adapted Model after Traumatic Brain Injury

  2011cited by this paper
• Comparison of Transdifferentiated and Untransdifferentiated Human Umbilical Mesenchymal Stem Cells in Rats after Traumatic Brain Injury

  2011cited by this paper
• Human umbilical cord blood mesenchymal stem cells protect mice brain after trauma*

  2011cited by this paper
• Stem cell survival and functional outcome after traumatic brain injury is dependent on transplant timing and location

  2011cited by this paper
• Transplantation of neural stem cells enhances expression of synaptic protein and promotes functional recovery in a rat model of traumatic brain injury.

  2011cited by this paper
• Mesenchymal Stem Cell Therapy Modulates the Inflammatory Response in Experimental Traumatic Brain Injury

  2011cited by this paper
• Neural Stem Cells Over-Expressing Brain-Derived Neurotrophic Factor (BDNF) Stimulate Synaptic Protein Expression and Promote Functional Recovery Following Transplantation in Rat Model of Traumatic Brain Injury

  2011cited by this paper
• Transplantation of Marrow Stromal Cells Restores Cerebral Blood Flow and Reduces Cerebral Atrophy in Rats with Traumatic Brain Injury: In vivo MRI Study

  2011cited by this paper
• Autologous Bone Marrow Mononuclear Cell Therapy for Severe Traumatic Brain Injury in Children

  2011cited by this paper
• In vivo tracking of 111In-labeled bone marrow mesenchymal stem cells in acute brain trauma model.

  2010cited by this paper
• Intravenous multipotent adult progenitor cell therapy for traumatic brain injury: preserving the blood brain barrier via an interaction with splenocytes.

  2010cited by this paper
• Comparison of transplantation of bone marrow stromal cells (BMSC) and stem cell mobilization by granulocyte colony stimulating factor after traumatic brain injury in rat.

  2010cited by this paper
• Stem cell biology in traumatic brain injury: effects of injury and strategies for repair.

  2010cited by this paper
• Direct Intrathecal Implantation of Mesenchymal Stromal Cells Leads to Enhanced Neuroprotection via an NFκB-Mediated Increase in Interleukin-6 Production

  2010cited by this paper
• Functional endothelial progenitor cells derived from adipose tissue show beneficial effect on cell therapy of traumatic brain injury.

  2010cited by this paper
• Laminin and fibronectin scaffolds enhance neural stem cell transplantation into the injured brain

  2009cited by this paper
• Endovascular transplantation of stem cells to the injured rat CNS

  2009cited by this paper
• Grafted neural progenitors migrate and form neurons after experimental traumatic brain injury

  2009cited by this paper
• Blockade of adrenoreceptors inhibits the splenic response to stroke.

  2009cited by this paper
• Transplantation of Embryonic Neural Stem/Precursor Cells Overexpressing BM88/Cend1 Enhances the Generation of Neuronal Cells in the Injured Mouse Cortex

  2009cited by this paper
• Advances in Progenitor Cell Therapy Using Scaffolding Constructs for Central Nervous System Injury

  2009cited by this paper
• Cerebral transplantation of encapsulated mesenchymal stem cells improves cellular pathology after experimental traumatic brain injury.

  2009cited by this paper
• Intravenous mesenchymal stem cell therapy for traumatic brain injury.

  2009cited by this paper
• Progenitor cell therapies for traumatic brain injury: barriers and opportunities in translation

  2009cited by this paper
• Understanding stem cell differentiation through self-organization theory.

  2008cited by this paper
• Neuroprotection in traumatic brain injury.

  2008cited by this paper
• Subacute neural stem cell therapy for traumatic brain injury.

  2008cited by this paper
• Trauma-Associated Inflammatory Response Impairs Embryonic Stem Cell Survival and Integration after Implantation into Injured Rat Brain

  2007cited by this paper
• Pluripotency of mesenchymal stem cells derived from adult marrow

  2007cited by this paper
• Guidelines for the management of severe traumatic brain injury.

  2007cited by this paper
• Embryonic Stem Cell Transplantation after Experimental Traumatic Brain Injury Dramatically Improves Neurological Outcome, But May Cause Tumors

  2007cited by this paper
• Basic fibroblast growth factor promotes bone marrow stromal cell transplantation-mediated neural regeneration in traumatic brain injury.

  2007cited by this paper
• Neuroinflammatory Responses After Experimental Diffuse Traumatic Brain Injury

  2007cited by this paper
• Long-term recovery after bone marrow stromal cell treatment of traumatic brain injury in rats.

  2006cited by this paper
• Transplantation of primed human fetal neural stem cells improves cognitive function in rats after traumatic brain injury.

  2006cited by this paper
• Sustained survival of xenografted human neural stem/progenitor cells in experimental brain trauma despite discontinuation of immunosuppression.

  2006cited by this paper
• Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.

  2006cited by this paper
• Neural progenitor cells engineered to secrete GDNF show enhanced survival, neuronal differentiation and improve cognitive function following traumatic brain injury

  2006cited by this paper
• Experimental Traumatic Brain Injury Modulates the Survival, Migration, and Terminal Phenotype of Transplanted Epidermal Growth Factor Receptor-activated Neural Stem Cells

  2005cited by this paper
• Human Marrow Stromal Cell Treatment Provides Long-lasting Benefit after Traumatic Brain Injury in Rats

  2005cited by this paper
• Transplantation of neural cells derived from retinoic acid-treated cynomolgus monkey embryonic stem cells successfully improved motor function of hemiplegic mice with experimental brain injury.

  2005cited by this paper
• Delayed Transplantation of Human Neurons following Brain Injury in Rats: A Long-Term Graft Survival and Behavior Study

  2005cited by this paper
• Cell Proliferation and Neuronal Differentiation in the Dentate Gyrus in Juvenile and Adult Rats following Traumatic Brain Injury

  2005cited by this paper
• Transplantation of Neuronal and Glial Precursors Dramatically Improves Sensorimotor Function but Not Cognitive Function in the Traumatically Injured Brain

  2004cited by this paper
• MHC expression after human neural stem cell transplantation to brain contused rats

  2004cited by this paper
• Marrow Stromal Cell Transplantation after Traumatic Brain Injury Promotes Cellular Proliferation within the Brain

  2004cited by this paper
• Intravenous Administration of Marrow Stromal Cells (MSCs) Increases the Expression of Growth Factors in Rat Brain after Traumatic Brain Injury

  2004cited by this paper
• Proliferation, migration, and differentiation of human neural stem/progenitor cells after transplantation into a rat model of traumatic brain injury.

  2004cited by this paper
• Neural progenitor cell transplants promote long-term functional recovery after traumatic brain injury.

  2004cited by this paper
• Ex Vivo Gene Therapy Using Targeted Engraftment of NGF-Expressing Human NT2N Neurons Attenuates Cognitive Deficits Following Traumatic Brain Injury in Mice

  2004cited by this paper
• Anatomical and functional recovery by embryonic stem cell-derived neural tissue of a mouse model of brain damage.

  2004cited by this paper
• Transplantation of Motoneuron-Enriched Neural Cells Derived from Mouse Embryonic Stem Cells Improves Motor Function of Hemiplegic Mice

  2003cited by this paper
• Treatment of traumatic brain injury in adult rats with intravenous administration of human bone marrow stromal cells.

  2003cited by this paper
• Neurogenesis and Glial Proliferation Persist for at Least One Year in the Subventricular Zone Following Brain Trauma in Rats

  2003cited by this paper
• Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma

  2003cited by this paper
• Genetically Modified NT2N Human Neuronal Cells Mediate Long‐Term Gene Expression as CNS Grafts In Vivo and Improve Functional Cognitive Outcome Following Experimental Traumatic Brain Injury

  2003cited by this paper
• Neuroprotection by human neural progenitor cells after experimental contusion in rats.

  2003cited by this paper
• Failure of bone marrow cells to transdifferentiate into neural cells in vivo.

  2002cited by this paper
• Transplanted Neural Stem Cells Survive, Differentiate, and Improve Neurological Motor Function after Experimental Traumatic Brain Injury

  2002cited by this paper
• Intracerebral Transplantation of Marrow Stromal Cells Cultured with Neurotrophic Factors Promotes Functional Recovery in Adult Rats Subjected to Traumatic Brain Injury

  2002cited by this paper
• Dynamic imaging in mild traumatic brain injury: support for the theory of medial temporal vulnerability.

  2002cited by this paper
• Neural and marrow-derived stromal cell sphere transplantation in a rat model of traumatic brain injury.

  2002cited by this paper
• Neuroprotective and behavioral efficacy of nerve growth factor-transfected hippocampal progenitor cell transplants after experimental traumatic brain injury.

  2001cited by this paper
• Treatment of Traumatic Brain Injury in Female Rats with Intravenous Administration of Bone Marrow Stromal Cells

  2001cited by this paper
• Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome

  2001cited by this paper
• Intraarterial Administration of Marrow Stromal Cells in a Rat Model of Traumatic Brain Injury

  2001cited by this paper
• Treatment of Traumatic Brain Injury in Adult Rats with Intravenous Administration of Human Bone Marrow Stromal Cells

  2001cited by this paper
• Transfectable and transplantable postmitotic human neurons: a potential "platform" for gene therapy of nervous system diseases.

  1997cited by this paper
• Hippocampal Pathology in Fatal Human Head Injury Without High Intracranial Pressure

  1994cited by this paper

• Protective effects of wogonin in the treatment of central nervous system and degenerative diseases.

  2025cites this paper
• Mechanisms and therapeutic potential of ozone therapy in enhancing vasculogenesis and angiogenesis through growth factor activation and oxidative signaling pathways

  2025cites this paper
• Intranasal delivery systems for traumatic brain injury: Advancements and perspectives

  2025cites this paper
• Arterial and venous flow dynamics are modified by age in the non-human primate

  2025cites this paper
• Exosomes beyond stem cells during traumatic brain injury: hype or hope?

  2025cites this paper
• Current evidence on umbilical cord and bone marrow stem cell therapy in TBI: A scoping review for future clinical practice

  2025cites this paper
• The pCREB/BDNF Pathway in the Hippocampus Is Involved in the Therapeutic Effect of Selective 5-HT Reuptake Inhibitors in Adult Male Rats Exposed to Blast Traumatic Brain Injury

  2025cites this paper
• The Breakdown of Neurovascular Barriers: Molecular Mechanisms of Tight Junction Dysfunction

  2025cites this paper
• Characteristics of Parthenogenetic Stem Cells and Their Potential Treatment Strategy for Central Nervous System Diseases

  2025cites this paper
• Advances in clinical translation of stem cell-based therapy in neurological diseases

  2025cites this paper
• Clinical Management in Traumatic Brain Injury

  2024cites this paper
• Stem Cell Interventions in Neurology: From Bench to Bedside

  2024cites this paper
• Non-pharmacological interventions for traumatic brain injury

  2024cites this paper
• Recent Advances in Biomaterials-Based Therapies for Alleviation and Regeneration of Traumatic Brain Injury.

  2023cites this paper
• Potential injectable hydrogels as biomaterials for central nervous system injury: A narrative review

  2023cites this paper
• Anti-inflammatory effect of dental pulp stem cells

  2023cites this paper
• Neurovascular Interventions for Neurotrauma: From Treatment of Injured Vessels to Treatment of the Injured Brain?

  2023cites this paper
• Therapeutic Effect of a Hydrogel-based Neural Stem Cell Delivery Sheet for Mild Traumatic Brain Injury.

  2023cites this paper
• Clonal mesenchymal stem cell-derived extracellular vesicles improve mouse model of weight drop-induced traumatic brain injury through reducing cistauosis and apoptosis.

  2023cites this paper
• Kinase inhibit region of SOCS3 attenuates IL6‐induced proliferation and astrocytic differentiation of neural stem cells via cross talk between signaling pathways

  2022cites this paper
• Cell therapies for acute and chronic traumatic brain injury

  2022cites this paper
• Guideline of clinical neurorestorative treatment for brain trauma (2022 China version)

  2022cites this paper
• The Effect of Oral Mucosal Mesenchymal Stem Cells on Pathological and Long-Term Outcomes in Experimental Traumatic Brain Injury

  2022cites this paper
• Traumatic brain injury and the development of parkinsonism: Understanding pathophysiology, animal models, and therapeutic targets.

  2022cites this paper
• Protective role of wogonin following traumatic brain injury by reducing oxidative stress and apoptosis via the PI3K/Nrf2/HO-1 pathway

  2022cites this paper
• Human embryonic stem cell-derived cerebral organoids for treatment of mild traumatic brain injury in a mouse model.

  2022cites this paper
• Magnetic resonance imaging focused on the ferritin heavy chain 1 reporter gene detects neuronal differentiation in stem cells

  2022cites this paper
• Stem cell sprays for neurological injuries: a perspective.

  2021cites this paper
• Traumatic Brain Injury: Mechanistic Insight on Pathophysiology and Potential Therapeutic Targets

  2021cites this paper
• Mesenchymal Stem Cells for Neurological Disorders

  2021cites this paper
• Effects of Selective Serotonin Reuptake Inhibitors on Depression-Like Behavior in a Laser-Induced Shock Wave Model

  2021cites this paper
• An Overview of Stem Cell Therapies for Parkinson’s Disease

  2021influential citation
• Bite-Sized Teaching Sessions Effects on Emergency Nurses' Knowledge and Practice Regarding Traumatic Brain Injury

  2021cites this paper
• Injectable hyaluronic acid hydrogel loaded with BMSC and NGF for traumatic brain injury treatment

  2021cites this paper
• Gene therapy for chronic traumatic brain injury: Challenges to resolve long-term consequences of brain damage.

  2021cites this paper
• Cryobanking of human distal lung epithelial cells for preservation of their phenotypic and functional characteristics

  2021cites this paper
• Future Perspectives in Spinal Cord Repair: Brain as Saviour? TSCI with Concurrent TBI: Pathophysiological Interaction and Impact on MSC Treatment

  2021cites this paper
• Developing a New Strategy for Delivery of Neural Transplant Populations Using Precursor Cell Sprays and Specialized Cell Media

  2021cites this paper
• Intranasally Administered L-Myc-Immortalized Human Neural Stem Cells Migrate to Primary and Distal Sites of Damage after Cortical Impact and Enhance Spatial Learning

  2021cites this paper
• Cellular and molecular imaging for stem cell tracking in neurological diseases

  2020cites this paper
• Resilience to Injury: A New Approach to Neuroprotection?

  2020cites this paper
• Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal cells

  2020cites this paper
• miR-210 enhances mesenchymal stem cell-modulated neural precursor cell migration

  2020cites this paper
• Stem cells application for the treatment of traumatic brain injury

  2020cites this paper
• Human adipose-derived mesenchymal stem cells for acute and sub-acute TBI

  2020cites this paper
• Cell therapy in experimental TBI

  2020influential citation
• Applying hiPSCs and Biomaterials Towards an Understanding and Treatment of Traumatic Brain Injury

  2020cites this paper
• Neural Stem Cells: Several Methodology In Regenerative Medicine To Cure Brain Injury

  2020cites this paper
• The Effect of Oral Mucosal Mesenchymal Stem Cells on Long-Term Brain Edema and Lesion, Anxiety-Like Behavior, and Cognitive and Motor Outcomes in Experimental Traumatic Brain Injury

  2020cites this paper
• Extracellular Vesicles Mediate Neuroprotection and Functional Recovery after Traumatic Brain Injury

  2019influential citation
• Differentiation of Mesenchymal Stem Cells to Neuroglia: in the Context of Cell Signalling

  2019cites this paper
• Human umbilical cord blood cells restore vascular integrity in injured rat brain and modulate inflammation in vitro.

  2019cites this paper
• Anti-inflammatory Effects of Traditional Chinese Medicines on Preclinical in vivo Models of Brain Ischemia-Reperfusion-Injury: Prospects for Neuroprotective Drug Discovery and Therapy

  2019cites this paper
• Feasibility of Human Neural Stem Cell Transplantation for the Treatment of Acute Subdural Hematoma in a Rat Model: A Pilot Study

  2019cites this paper
• Matrices, scaffolds & carriers for cell delivery in nerve regeneration.

  2019cites this paper
• Effectiveness of Educational Nursing Strategies on Nurse’s Knowledge and Skills regarding Traumatic Head Injury in Children

  2019cites this paper
• Superparamagnetic graphene quantum dot as a dual‐modality contrast agent for confocal fluorescence microscopy and magnetomotive optical coherence tomography

  2018cites this paper
• Nasolacrimal way of stem cells implantation

  2018cites this paper
• Biomaterial Scaffolds in Regenerative Therapy of the Central Nervous System

  2018cites this paper
• Nerve growth factor plays a role in the neurotherapeutic effect of a CD45+ pan-hematopoietic subpopulation derived from human umbilical cord blood in a traumatic brain injury model.

  2018cites this paper
• Treatment of Traumatic Brain Injury U sing Neural Stem Cells

  2018influential citation
• Treating childhood traumatic brain injury with autologous stem cell therapy

  2018cites this paper
• MRI Tracking of iPS Cells-Induced Neural Stem Cells in Traumatic Brain Injury Rats

  2018cites this paper
• Exploring Pharmacological Mechanisms of Xuefu Zhuyu Decoction in the Treatment of Traumatic Brain Injury via a Network Pharmacology Approach

  2018cites this paper
• Neuroprotection in Traumatic Brain Injury: Mesenchymal Stromal Cells can Potentially Overcome Some Limitations of Previous Clinical Trials

  2018cites this paper
• Placenta-Derived Cells for Acute Brain Injury

  2018cites this paper
• A Review of Stem Cell Therapy for Acquired Brain Injuries and Neurodegenerative Central Nervous System Diseases

  2018cites this paper
• Traumatic Brain Injury

  2017influential citation
• Upregulation of 3-MST Relates to Neuronal Autophagy After Traumatic Brain Injury in Mice

  2017cites this paper
• Endothelial Progenitor Cells Correlated with Oxidative Stress after Mild Traumatic Brain Injury

  2017cites this paper
• Seven days post-injury fate and effects of genetically labelled adipose-derived mesenchymal cells on a rat traumatic brain injury experimental model.

  2017cites this paper
• Evaluation of Parametric Response Mapping to Assess Therapeutic Response to Human Mesenchymal Stem Cells after Experimental Stroke

  2017cites this paper
• From Blood to Lesioned Brain: An In Vitro Study on Migration Mechanisms of Human Nasal Olfactory Stem Cells

  2017cites this paper
• Long-Term Motor Deficits after Controlled Cortical Impact in Rats Can Be Detected by Fine Motor Skill Tests but Not by Automated Gait Analysis

  2017cites this paper
• Induced neural stem cells modulate microglia activation states via CXCL12/CXCR4 signaling.

  2017cites this paper
• Mesenchymal stem cells maintain the microenvironment of central nervous system by regulating the polarization of macrophages/microglia after traumatic brain injury

  2017influential citation
• Biological characters of human dermal fibroblasts derived from foreskin of male infertile patients.

  2017cites this paper
• Amelioration of Penetrating Ballistic-Like Brain Injury Induced Cognitive Deficits after Neuronal Differentiation of Transplanted Human Neural Stem Cells

  2017cites this paper
• One Step at a Time, Stem Cell Therapy for Traumatic Brain Injury Needs Two More Breakthroughs

  2016cites this paper
• Mesenchymal Stem Cells of Dental Origin-Their Potential for Anti-inflammatory and Regenerative Actions in Brain and Gut Damage

  2016cites this paper
• The Role of Stem Cells in the Treatment of Cerebral Palsy: a Review

  2016cites this paper
• Innovations in Molecular Mechanisms and Tissue Engineering

  2016cites this paper
• Regenerative Strategies for the Central Nervous System

  2016cites this paper
• Electrospun nanoyarn seeded with myoblasts induced from placental stem cells for the application of stress urinary incontinence sling: An in vitro study.

  2016cites this paper
• One step at a time, stem cell therapy for traumatic brain injury needs two more breakthroughs

  2016cites this paper
• Future of Critical Care Medicine

  2016cites this paper
• Neuroanesthesiology Update

  2016cites this paper
• Treatment and Research Progress of Traumatic Brain Injury

  year unknowncites this paper