Iron regulatory element and internal loop/bulge structure for ferritin mRNA studied by cobalt(III) hexammine binding, molecular modeling, and NMR spectroscopy.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Biochemistry

• Publication date

  1998-01-23

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/BI9719814PMID 9484220
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ferritin mRNA probed, near the iron regulatory region, with protein and chemical (1,10-phenanthroline-Cu) nucleases A possible role for base-paired flanking regions

  2005cited by this paper
• Solution structure of a metal-binding site in the major groove of RNA complexed with cobalt (III) hexammine.

  1997cited by this paper
• Probing the structure of the regulatory region of human transferrin receptor messenger RNA and its interaction with iron regulatory protein-1.

  1997cited by this paper
• Solution structure of the HIV-2 TAR-argininamide complex.

  1997cited by this paper
• Structure and dynamics of the iron responsive element RNA: implications for binding of the RNA by iron regulatory binding proteins.

  1997cited by this paper
• Effects of the ferritin open reading frame on translational induction by iron.

  1996cited by this paper
• Sequence effects on RNA bulge-induced helix bending and a conserved five-nucleotide bulge from the group I introns.

  1996cited by this paper
• Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

  1996cited by this paper
• Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing

  1996cited by this paper
• Differences in the RNA binding sites of iron regulatory proteins and potential target diversity.

  1996cited by this paper
• A constant-time 13C−1H HSQC with uniform excitation over the complete 13C chemical shift range

  1995cited by this paper
• The importance of a single G in the hairpin loop of the iron responsive element (IRE) in ferritin mRNA for structure: an NMR spectroscopy study

  1995cited by this paper
• Determination of nucleotide distances in RNA by means of copper phenanthroline-generated hydroxyl radical cleavage pattern.

  1995cited by this paper
• Multidimensional heteronuclear NMR experiments for structure determination of isotopically labeled RNA.

  1995cited by this paper
• Solution Structure of a Bovine Immunodeficiency Virus Tat-TAR Peptide-RNA Complex

  1995cited by this paper
• Improved sensitivity of HSQC spectra of exchanging protons at short interscan delays using a new fast HSQC (FHSQC) detection scheme that avoids water saturation.

  1995cited by this paper
• 1H NMR studies of the high-affinity Rev binding site of the Rev responsive element of HIV-1 mRNA: base pairing in the core binding element.

  1994cited by this paper
• The iron-responsive element-binding protein: localization of the RNA-binding site to the aconitase active-site cleft.

  1994cited by this paper
• Optimal sequence and structure of iron-responsive elements. Selection of RNA stem-loops with high affinity for iron regulatory factor.

  1994cited by this paper
• The putative iron-responsive element in the human erythroid 5-aminolevulinate synthase mRNA mediates translational control.

  1993cited by this paper
• The influence of the base-paired flanking region on structure and function of the ferritin mRNA iron regulatory element.

  1993cited by this paper
• Preparation of 13C and 15N labelled RNAs for heteronuclear multi-dimensional NMR studies.

  1992cited by this paper
• The iron regulatory region of ferritin mRNA is also a positive control element for iron-independent translation.

  1992cited by this paper
• Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions

  1992cited by this paper
• Ferritin mRNA: interactions of iron regulatory element with translational regulator protein P-90 and the effect on base-paired flanking regions.

  1991cited by this paper
• Preparation of a mixture of nucleoside triphosphates suitable for use in synthesis of nucleotide phosphate sugars from ribonucleic acid using nuclease P1, a mixture of nucleoside monophosphokinases and acetate kinase

  1990cited by this paper
• Chemical nucleases.

  1990cited by this paper
• Structure of the 5' untranslated regulatory region of ferritin mRNA studied in solution.

  1990cited by this paper
• Use of T7 RNA polymerase to direct expression of cloned genes.

  1990cited by this paper
• The importance of the 3'-untranslated region in the translational control of ferritin mRNA.

  1988cited by this paper
• Regulation of ferritin mRNA: a possible gene-sparing phenomenon. Induction of ferritin synthesis by iron in liver as well as red cells combines high translational efficiency with increased utilization of preformed ferritin mRNA.

  1983cited by this paper
• Translational control of ferritin synthesis by iron in embryonic reticulocytes of the bullfrog.

  1982cited by this paper

• Origin of ribonucleotide recognition motifs through ligand mimicry at early earth

  2024cites this paper
• Ferroptosis: Regulatory mechanisms and potential targets for bone metabolism: A review

  2024cites this paper
• A Review on Biologically Active oxo-bridged diiron (III,III) centers

  2024cites this paper
• Modulation of iron metabolism by new chemicals interacting with the iron regulatory system

  2024cites this paper
• Iron-dependent post transcriptional control of mitochondrial aconitase expression.

  2023cites this paper
• Interaction of ferritin iron responsive element (IRE) mRNA with translation initiation factor eIF4F.

  2020cites this paper
• Iron regulates mRNA translation initiation through RNA iron responsive element (IRE)

  2020cites this paper
• Adverse effects of the renal accumulation of haem proteins. Novel therapeutic approaches.

  2018cites this paper
• Adverse effects of the renal accumulation of haem proteins. Novel therapeutic approaches

  2018cites this paper
• Iron regulates mRNA translation initiation through RNA iron responsive element ( IRE )

  2017cites this paper
• Thermodynamic and Kinetic Analyses of Iron Response Element (IRE)-mRNA Binding to Iron Regulatory Protein, IRP1

  2017cites this paper
• Rapid kinetics of iron responsive element (IRE) RNA/iron regulatory protein 1 and IRE-RNA/eIF4F complexes respond differently to metal ions

  2014cites this paper
• Iron regulates mRNA translation initiation through RNA iron responsive element (IRE)

  2014cites this paper
• RNA Information Gene Diseases: Nano-RNA-Based Medical Devices with Corporate Chemotherapy and Gene Therapy

  2014cites this paper
• Mammalian iron metabolism and its control by iron regulatory proteins.

  2012cites this paper
• Fe2+ binds iron responsive element-RNA, selectively changing protein-binding affinities and regulating mRNA repression and activation

  2012cites this paper
• Spectroscopic investigations of lanthanide ion binding to nucleic acids.

  2012cites this paper
• Solution structure of an alternate conformation of helix27 from Escherichia coli16S rRNA.

  2011cites this paper
• Iron responsive mRNAs: a family of Fe2+ sensitive riboregulators.

  2011cites this paper
• Nature of guanine oxidation in RNA via the flash-quench technique versus direct oxidation by a metal oxo complex.

  2010cites this paper
• Ferritin iron minerals are chelator targets, antioxidants, and coated, dietary iron

  2010cites this paper
• Multiple determinants within iron-responsive elements dictate iron regulatory protein binding and regulatory hierarchy.

  2010cites this paper
• Roles of protons and structure in electron -transfer reactions of DNA and RNA

  2009cites this paper
• Cysteine Oxidation Regulates the RNA-Binding Activity of Iron Regulatory Protein 2

  2009cites this paper
• Fluorescence and NMR studies of the role of metal ions in HIV-1 genomic RNA dimerization and maturation

  2009cites this paper
• Direct Fe2+ Sensing by Iron-responsive Messenger RNA·Repressor Complexes Weakens Binding*

  2009cites this paper
• Living with iron (and oxygen): questions and answers about iron homeostasis.

  2009cites this paper
• RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha.

  2008cites this paper
• Dynamics, Degradation, and Chemical Modification of Non-Coding RNA

  2008cites this paper
• The functional duality of iron regulatory protein 1.

  2008cites this paper
• Computational identification of non-coding RNAs

  2007cites this paper
• Evolution of the iron-responsive element.

  2007influential citation
• The family of iron responsive RNA structures regulated by changes in cellular iron and oxygen

  2007cites this paper
• Renal iron metabolism: transferrin iron delivery and the role of iron regulatory proteins.

  2007cites this paper
• Finding a Common Motif of RNA Sequences Using Genetic Programming: The GeRNAMo System

  2007influential citation
• RNA-Binding Proteins HuR and PTB Promote the Translation of Hypoxia-Inducible Factor 1α

  2007cites this paper
• Coordinating responses to iron and oxygen stress with DNA and mRNA promoters: The ferritin story

  2007cites this paper
• Crystallization and preliminary X-ray diffraction analysis of iron regulatory protein 1 in complex with ferritin IRE RNA.

  2006cites this paper
• The up-regulation of ferritin expression using a small-molecule ligand to the native mRNA.

  2006cites this paper
• Probing RNA hairpins with cobalt(III)hexammine and electrospray ionization mass spectrometry

  2006cites this paper
• The role of iron regulatory proteins in mammalian iron homeostasis and disease

  2006cites this paper
• FOCUS: NUCLEIC ACIDS IN MASS SPECTROMETRY Probing RNA Hairpins with Cobalt(III)hexammine and Electrospray Ionization Mass Spectrometry

  2006cites this paper
• Cellular regulation and molecular interactions of the ferritins

  2006cites this paper
• Ferritins: iron/oxygen biominerals in protein nanocages

  2006cites this paper
• FOCUS :N UCLEIC ACIDS IN MASS SPECTROMETRY Probing RNA Hairpins with Cobalt(III)hexammine and Electrospray Ionization Mass Spectrometry

  2006cites this paper
• Molecular control of vertebrate iron homeostasis by iron regulatory proteins.

  2006cites this paper
• Structure of Dual Function Iron Regulatory Protein 1 Complexed with Ferritin IRE-RNA

  2006cites this paper
• Integrating iron and oxygen/antioxidant signals via a combinatorial array of DNA - (antioxidant response elements) and mRNA (iron responsive elements) sequences.

  2006cites this paper
• Cellular regulation and molecular interactions of the ferritins

  2006cites this paper
• Mapping nucleic acid structure by hydroxyl radical cleavage.

  2005cites this paper
• Solution probing of metal ion binding by helix 27 from Escherichia coli 16S rRNA.

  2005influential citation
• Parameter optimization of an evolutionary algorithm for RNA structure discovery

  2004cites this paper
• Iron and ageing: an introduction to iron regulatory mechanisms.

  2004cites this paper
• RNAProfile: an algorithm for finding conserved secondary structure motifs in unaligned RNA sequences.

  2004cites this paper
• The Apical Loop of the HIV-1 TAR RNA Hairpin Is Stabilized by a Cross-loop Base Pair*

  2003cites this paper
• Gene expression in the trabecular meshwork and the influence of intraocular pressure.

  2003cites this paper
• pH dependent conformational changes within the iron responsive element

  2002influential citation
• Discovery of RNA structural elements using evolutionary computation.

  2002cites this paper
• Molecular and Cellular Iron Transport

  2002influential citation
• Expression profile and genome location of cDNA clones from an infant human trabecular meshwork cell library.

  2002cites this paper
• Structural Changes Associated with Switching Activities of Human Iron Regulatory Protein 1*

  2002cites this paper
• Multiple, Conserved Iron-responsive Elements in the 3′-Untranslated Region of Transferrin Receptor mRNA Enhance Binding of Iron Regulatory Protein 2*

  2002cites this paper
• The bulge region of HIV-1 TAR RNA binds metal ions in solution.

  2002cites this paper
• An mRNA Loop/Bulge in the Ferritin Iron-responsive Element Forms in Vivo and Was Detected by Radical Probing with Cu-1,10-phenantholine and Iron Regulatory Protein Footprinting*

  2002cites this paper
• Iron-Responsive Elements (IRE)

  2002cites this paper
• Post-Transcriptional Regulation of Iron Metabolism

  2002cites this paper
• Systemic iron metabolism: a review and implications for brain iron metabolism.

  2001cites this paper
• RNAMotif, an RNA secondary structure definition and search algorithm.

  2001cites this paper
• The Hairpin Loop but Not the Bulged C of the Iron Responsive Element Is Essential for High Affinity Binding to Iron Regulatory Protein-1*

  2001cites this paper
• Stress Conditions Applied to the Interpretation Of Translation Machinery

  2001cites this paper
• Effects of cobalt hexammine on folding and self-cleavage of the Neurospora VS ribozyme.

  2001cites this paper
• The roles of iron in health and disease.

  2001cites this paper
• Internal loop/bulge and hairpin loop of the iron-responsive element of ferritin mRNA contribute to maximal iron regulatory protein 2 binding and translational regulation in the iso-iron-responsive element/iso-iron regulatory protein family.

  2000cites this paper
• Iron regulatory proteins and the molecular control of mammalian iron metabolism.

  2000cites this paper
• Determination of metal ion binding sites within the hairpin ribozyme domains by NMR.

  2000cites this paper
• In vivo, high-resolution analysis of yeast and mammalian RNA-protein interactions, RNA structure, RNA splicing and ribozyme cleavage by use of terminal transferase-dependent PCR.

  2000cites this paper
• Targeting mRNA to regulate iron and oxygen metabolism.

  2000cites this paper
• Metal-phosphate interactions in the hammerhead ribozyme observed by 31P NMR and phosphorothioate substitutions.

  2000cites this paper
• Cobalt hexammine inhibition of the hammerhead ribozyme.

  2000cites this paper
• Combinatorial mRNA Regulation: Iron Regulatory Proteins and Iso-iron-responsive Elements (Iso-IREs)*

  2000cites this paper
• Conformational dynamics of a 5S rRNA hairpin domain containing loop D and a single nucleotide bulge.

  2000cites this paper
• The IRE Model for Families of RNA Structures

  1999cites this paper
• Regulation of the iron regulatory proteins by reactive nitrogen and oxygen species.

  1999cites this paper
• Iron metabolism.

  1999cites this paper
• Identification of RNA‐binding surfaces in iron regulatory protein‐1

  1999influential citation
• 12 The Role of Metal Ions in RNA Biochemistry

  1999cites this paper
• Structure of influenza virus panhandle RNA studied by NMR spectroscopy and molecular modeling.

  1999cites this paper
• Regulation of genes of iron metabolism by the iron-response proteins.

  1999cites this paper
• Thermodynamics of stabilization of RNA pseudoknots by cobalt(III) hexaammine.

  1999cites this paper
• Recent Advances in Nutritional Science IronRegulatoryProteins,IronResponsiveElementsandIronHomeostasis 1,2

  1998cites this paper
• Oxidation of guanines in the iron-responsive element RNA: similar structures from chemical modification and recent NMR studies.

  1998cites this paper
• Exploration of metal ion binding sites in RNA folds by Brownian-dynamics simulations.

  1998cites this paper
• Loops and Bulge/Loops in Iron-responsive Element Isoforms Influence Iron Regulatory Protein Binding

  1998cites this paper
• Iron regulatory proteins, iron responsive elements and iron homeostasis.

  1998cites this paper