ΔRaf-1:ER* Bypasses the Cyclic AMP Block of Extracellular Signal-Regulated Kinase 1 and 2 Activation but Not CDK2 Activation or Cell Cycle Reentry

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Molecular and Cellular Biology

• Publication date

  2003-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1128/MCB.23.24.9303-9317.2003PMID 14645540PMCID PMC309715
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Activation of ERK1/2 by ΔRaf-1 : ER* represses Bim expression independently of the JNK or PI3K pathways

  2003cited by this paper
• ΔMEKK3:ER* activation induces a p38α/β2-dependent cell cycle arrest at the G2 checkpoint

  2002cited by this paper
• Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry

  2002cited by this paper
• Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1.

  2002cited by this paper
• Mutations of the BRAF gene in human cancer

  2002cited by this paper
• A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK

  2002cited by this paper
• AP-1 as a regulator of cell life and death

  2002cited by this paper
• Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation.

  2002cited by this paper
• Cyclic AMP-Dependent Kinase Regulates Raf-1 Kinase Mainly by Phosphorylation of Serine 259

  2002influential reference
• Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint.

  2002cited by this paper
• Cyclic AMP Blocks Cell Growth through Raf-1-Dependent and Raf-1-Independent Mechanisms

  2002influential reference
• Role of p27(Kip1) in cAMP- and TGF-beta2-mediated antiproliferation in rabbit corneal endothelial cells.

  2001cited by this paper
• Role of p27Kip1 in cAMP- and TGF-β2–Mediated Antiproliferation in Rabbit Corneal Endothelial Cells

  2001cited by this paper
• Cyclic AMP-Mediated Inhibition of Cell Growth Requires the Small G Protein Rap1

  2001cited by this paper
• Radiologic-Pathologic Correlation of Unusual Lingual Masses: Part II: Benign and Malignant Tumors

  2001cited by this paper
• Signalling pathways of insulin-like growth factor-I that are augmented by cAMP in FRTL-5 cells.

  2000cited by this paper
• Involvement of Myc Activity in a G1/S-Promoting Mechanism Parallel to the pRb/E2F Pathway

  2000cited by this paper
• The p21WAF1/CIP1 Promoter Is Methylated in Rat-1 Cells: Stable Restoration of p53-Dependent p21WAF1/CIP1 Expression after Transfection of a Genomic Clone Containing the p21WAF1/CIP1 Gene

  2000cited by this paper
• Induction of p21WAF1 expression via Sp1-binding sites by tamoxifen in estrogen receptor-negative lung cancer cells

  2000cited by this paper
• The cAMP Signaling Pathway as a Therapeutic Target in Lymphoid Malignancies

  2000cited by this paper
• Phosphorylation of Serine 43 Is Not Required for Inhibition of c-Raf Kinase by the cAMP-dependent Protein Kinase*

  2000influential reference
• Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling.

  2000cited by this paper
• Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions.

  2000cited by this paper
• Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.

  2000cited by this paper
• The p21(WAF1/CIP1) promoter is methylated in Rat-1 cells: stable restoration of p53-dependent p21(WAF1/CIP1) expression after transfection of a genomic clone containing the p21(WAF1/CIP1) gene.

  2000cited by this paper
• Cell cycle regulation by the Cdc25 phosphatase family.

  2000cited by this paper
• The biphasic induction of p21 and p27 in breast cancer cells by modulators of cAMP is posttranscriptionally regulated and independent of the PKA pathway.

  1999cited by this paper
• Differential regulation of extracellular signal-regulated protein kinases (ERKs) 1 and 2 by cAMP and dissociation of ERK inhibition from anti-mitogenic effects in rabbit vascular smooth muscle cells.

  1999cited by this paper
• Rescue of cyclin D1 deficiency by knockin cyclin E.

  1999cited by this paper
• Cyclin D3 accumulation and activity integrate and rank the comitogenic pathways of thyrotropin and insulin in thyrocytes in primary culture

  1999cited by this paper
• Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells

  1999cited by this paper
• CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S Phase

  1999cited by this paper
• Activated MEK Stimulates Expression of AP-1 Components Independently of Phosphatidylinositol 3-Kinase (PI3-Kinase) but Requires a PI3-Kinase Signal To Stimulate DNA Synthesis

  1999cited by this paper
• Ectopic Expression of Cdc25A Accelerates the G1/S Transition and Leads to Premature Activation of Cyclin E- and Cyclin A-Dependent Kinases

  1999cited by this paper
• How do small GTPase signal transduction pathways regulate cell cycle entry?

  1999influential reference
• Effects of Cyclic AMP on Components of the Cell Cycle Machinery Regulating DNA Synthesis in Cultured Astrocytes

  1999cited by this paper
• The Repertoire of Fos and Jun Proteins Expressed during the G1 Phase of the Cell Cycle Is Determined by the Duration of Mitogen-Activated Protein Kinase Activation

  1999influential reference
• Signal transduction through MAP kinase cascades.

  1998cited by this paper
• Synergistic effect of cyclic AMP and insulin on the expression of cyclin A gene in Swiss 3T3 cells.

  1998cited by this paper
• Cell cycle targets of Ras/Raf signalling

  1998influential reference
• Activation and repression of p21WAF1/CIP1 transcription by RB binding proteins

  1998cited by this paper
• The regulation of E2F by pRB-family proteins.

  1998influential reference
• Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.

  1997cited by this paper
• Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1

  1997influential reference
• Cyclic AMP negatively controls c-myc transcription and G1 cell cycle progression in p210 BCR-ABL transformed cells: inhibitory activity exerted through cyclin D1 and cdk4

  1997cited by this paper
• The dog thyroid primary culture system: a model of the regulation of function, growth and differentiation expression by cAMP and other well-defined signaling cascades.

  1997cited by this paper
• Regulation of Mitogen-activated Protein Kinase Phosphatase-1 Expression by Extracellular Signal-related Kinase-dependent and Ca2+-dependent Signal Pathways in Rat-1 Cells*

  1997cited by this paper
• G1 phase arrest of human smooth muscle cells by heparin, IL-4 and cAMP is linked to repression of cyclin D1 and cdk2.

  1997cited by this paper
• cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway.

  1997cited by this paper
• New functional activities for the p21 family of CDK inhibitors.

  1997influential reference
• The effect of cyclic adenosine monophosphate on the mitogen-activated protein kinase pathway depends on both the cell type and the type of tyrosine kinase-receptor.

  1997cited by this paper
• Mitogen-activated protein kinase pathways.

  1997cited by this paper
• Effect of dibutyryl cyclic AMP on the cyclin-dependent kinase inhibitor p27Kip1 in the human hepatoma cells PLC/PRF/5.

  1997cited by this paper
• Cyclin D1 expression is a major target of the cAMP-induced inhibition of cell cycle entry in fibroblasts

  1997cited by this paper
• Negative regulation of Raf-1 by phosphorylation of serine 621

  1996influential reference
• cAMP-mediated Growth Inhibition in Fibroblasts Is Not Mediated via Mitogen-activated Protein (MAP) Kinase (ERK) Inhibition

  1996cited by this paper
• Cdc25 cell-cycle phosphatase as a target of c-myc

  1996cited by this paper
• Requirement of p27Kip1 for Restriction Point Control of the Fibroblast Cell Cycle

  1996cited by this paper
• Expression and subcellular localization of CDK2 and cdc2 kinases and their common partner cyclin A in thyroid epithelial cells: Comparison of cyclic AMP‐dependent and ‐independent cell cycles

  1996cited by this paper
• Perturbation of cell cycle regulators in human cancer.

  1996cited by this paper
• Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

  1996cited by this paper
• E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.

  1995cited by this paper
• The MEK Kinase Activity of the Catalytic Domain of RAF-1 Is Regulated Independently of Ras Binding in T Cells (*)

  1995cited by this paper
• Differential regulation of Raf-1 and B-Raf and Ras-dependent activation of mitogen-activated protein kinase by cyclic AMP in PC12 cells

  1995cited by this paper
• Differential effects on cAMP on the MAP kinase cascade: evidence for a cAMP-insensitive step that can bypass Raf-1.

  1995cited by this paper
• A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins.

  1995cited by this paper
• Overexpression of cyclin A in the mammary glands of transgenic mice results in the induction of nuclear abnormalities and increased apoptosis.

  1995cited by this paper
• TGF-beta 1 and cAMP attenuate cyclin A gene transcription via a cAMP responsive element through independent pathways.

  1995cited by this paper
• Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.

  1994cited by this paper
• Participation of cyclin A in Myc-induced apoptosis.

  1994cited by this paper
• Mechanism of inhibition of Raf-1 by protein kinase A

  1994cited by this paper
• cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts.

  1994cited by this paper
• Cdc25A is a novel phosphatase functioning early in the cell cycle.

  1994cited by this paper
• Inhibition by cAMP of Ras-dependent activation of Raf.

  1993influential reference
• Human cyclin D1 encodes a labile nuclear protein whose synthesis is directly induced by growth factors and suppressed by cyclic AMP.

  1993cited by this paper
• Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase

  1993cited by this paper
• cAMP antagonizes p21ras‐directed activation of extracellular signal‐regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.

  1993cited by this paper
• Identification of the major phosphorylation sites of the Raf-1 kinase.

  1993cited by this paper
• Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate.

  1993cited by this paper
• Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

  1993cited by this paper
• Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.

  1992cited by this paper
• Cyclin activation of p34cdc2.

  1990cited by this paper
• Site‐selective 8‐chloroadenosine 3′,5′‐cyclic monophosphate inhibits transformation and transforming growth factor α production in Ki‐ras‐transformed rat fibroblasts

  1989cited by this paper
• Cyclic AMP inhibits mitogen‐induced DNA synthesis in hamster fibroblasts, regardless of the signalling pathway involved

  1989cited by this paper
• Inhibition of growth and modulation of gene expression in human lung carcinoma in athymic mice by site-selective 8-Cl-cyclic adenosine monophosphate.

  1989cited by this paper
• Role of cyclic nucleotides in growth control.

  1975cited by this paper

• Somatostatin and Somatostatin Receptors in Tumour Biology

  2023cites this paper
• Assessment of the impact of deregulated signal transduction pathways on the radiotherapy response of non-small-cell lung cancer

  2018cites this paper
• Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling

  2014cites this paper
• Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression.

  2014cites this paper
• Treating brain tumors with PDE4 inhibitors.

  2011cites this paper
• Signal control through Raf: in sickness and in health

  2011cites this paper
• Increased mitogen-activated protein kinase kinase/extracellularly regulated kinase activity in human endometrial stromal fibroblasts of women with endometriosis reduces 3',5'-cyclic adenosine 5'-monophosphate inhibition of cyclin D1.

  2009cites this paper
• Phospholipase C delta 1 regulates cell proliferation and cell-cycle progression from G1- to S-phase by control of cyclin E-CDK2 activity.

  2008cites this paper
• Cyclic AMP inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation.

  2008cites this paper
• Blocking CXCR 4-Mediated Cyclic AMP Suppression Inhibits Brain Tumor Growth In vivo

  2007cites this paper
• Rafs constitute a nodal point in the regulation of embryonic endothelial progenitor cell growth and differentiation

  2007cites this paper
• Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo.

  2007cites this paper
• The effects of PACAP on neural cell proliferation.

  2006cites this paper
• Radiotherapy-induced signal transduction.

  2006influential citation
• Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways

  2005cites this paper
• H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.

  2005cites this paper
• Radiation-Stimulated ERK1/2 and JNK1/2 Signaling can Promote Cell Cycle Progression in Human Colon Cancer Cells

  2005cites this paper
• The Long and Short of Vascular Smooth Muscle Phosphodiesterase-4 As a Putative Therapeutic Target

  2005cites this paper
• Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.

  2005cites this paper
• Activation of FoxO transcription factors contributes to the antiproliferative effect of cAMP

  2005cites this paper