Signal-transduction pathways that regulate visceral smooth muscle function. III. Coupling of muscarinic receptors to signaling kinases and effector proteins in gastrointestinal smooth muscles.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  American Journal of Physiology - Gastrointestinal and Liver Physiology

• Publication date

  2005-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/AJPGI.00530.2004PMID 15826932
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• G protein-mediated dysfunction of excitation-contraction coupling in ileal inflammation.

  2004cited by this paper
• Muscarinic M2 Receptor Stimulation of Cav1.2b Requires Phosphatidylinositol 3-Kinase, Protein Kinase C, and c-Src

  2004cited by this paper
• ATP-dependent regulation of SK4/IK1-like currents in rat submandibular acinar cells: possible role of cAMP-dependent protein kinase.

  2004cited by this paper
• Phosphorylated HSP27 essential for acetylcholine-induced association of RhoA with PKCalpha.

  2004cited by this paper
• Translocation and association of ROCK-II with RhoA and HSP27 during contraction of rabbit colon smooth muscle cells.

  2004influential reference
• Tropomyosin interacts with phosphorylated HSP27 in agonist-induced contraction of smooth muscle.

  2004cited by this paper
• Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphat

  2003cited by this paper
• MAPK mediates PKC-dependent contraction of cat esophageal and lower esophageal sphincter circular smooth muscle.

  2003cited by this paper
• Erk1/2- and p38 MAP kinase-dependent phosphorylation and activation of cPLA2 by m3 and m2 receptors.

  2003influential reference
• Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase.

  2003cited by this paper
• Coupling of M2 muscarinic receptor to L-type Ca channel via c-src kinase in rabbit colonic circular smooth muscle.

  2002cited by this paper
• Coupling of M(2) muscarinic receptors to Src activation in cultured canine colonic smooth muscle cells.

  2002influential reference
• Coupling of M2 muscarinic receptors to Src activation in cultured canine colonic smooth muscle cells

  2002cited by this paper
• Investigations into the physiological role of muscarinic M2 and M4 muscarinic and M4 receptor subtypes using receptor knockout mice.

  2001cited by this paper
• Muscarinic receptors and gastrointestinal tract smooth muscle function.

  2001cited by this paper
• Coupling of M(2) muscarinic receptors to ERK MAP kinases and caldesmon phosphorylation in colonic smooth muscle.

  2000influential reference
• Evidence for modulation of smooth muscle force by the p38 MAP kinase/HSP27 pathway.

  2000cited by this paper
• Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle.

  2000cited by this paper
• Phosphatidylinositol 3-kinases regulate ERK and p38 MAP kinases in canine colonic smooth muscle.

  2000influential reference
• p38 MAP kinase pathway regulates angiotensin II-induced contraction of rat vascular smooth muscle.

  2000influential reference
• A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration*

  1999cited by this paper
• A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration.

  1999cited by this paper
• p38 Mitogen-activated protein kinase expression and activation in smooth muscle.

  1998cited by this paper
• Development of heart rate irregularities in chick embryos.

  1998cited by this paper
• Development of heart rate irregularities in chick embryos.

  1998cited by this paper
• Activation of MAP kinases and phosphorylation of caldesmon in canine colonic smooth muscle.

  1996cited by this paper
• Muscarinic receptors in canine colonic circular smooth muscle. II. Signal transduction pathways.

  1991cited by this paper
• Muscarinic receptors in canine colonic circular smooth muscle. I. Coexistence of M2 and M3 subtypes.

  1991cited by this paper
• Hsp27 is a mediator of sustained smooth muscle contraction in response to bombesin.

  1991cited by this paper
• highlighted topics Signal Transduction in Smooth Muscle Invited Review: Focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscle

  year unknowncited by this paper

• Sex-dependent alteration of the enteric neuromuscular function after antibiotic-induced dysbiosis in juvenile mice and effect of Lactocaseibacillus rhamnosus GG.

  2025cites this paper
• Pharmacological disadvantages in the spasmolytic effects by using the mixture known as "three toronjiles" in folk medicine.

  2023cites this paper
• In Vitro Assessment of Myorelaxant and Antispasmodic Effects of Stigmas, Tepals, and Leaves Hydroethanolic Extracts of Crocus sativus

  2023cites this paper
• Schistosoma mansoni excretory-secretory products induce protein kinase signalling, hyperkinesia, and stem cell proliferation in the opposite sex

  2023cites this paper
• Ageing causes an aortic contractile dysfunction phenotype by targeting the expression of members of the extracellular signal‐regulated kinase pathway

  2022cites this paper
• Effect of methanol extract of Anacardium occidentale stem bark on agonist-induced contraction in rat uterine muscle

  2021cites this paper
• Effects of Steganotaenia Araliacae Root Extract on Contractile Function of Isolated Rat Ileum

  2021cites this paper
• Effect of the leaves aqueous extract of Jodina rhombifolia (Hook. & Arn.) Reissek (Santalaceae) on intestinal function and its acute toxicity.

  2020cites this paper
• Study of Antispasmodic and Antidiarrheal Activities of Tagetes lucida (Mexican Tarragon) in Experimental Models and Its Mechanism of Action

  2020cites this paper
• Diterpenoids from Leaves of Cultivated Plectranthus ornatus

  2020cites this paper
• Enteric Nervous System Remodeling in a Rat Model of Spinal Cord Injury: A Pilot Study

  2020cites this paper
• Ste20-Like Kinase (SLK) Mediated Control of Actin Polymerization is a New Mechanism for Thin Filament Associated Regulation of Airway Smooth Muscle Contraction.

  2020cites this paper
• Mouse Embryonic Stem Cells Lacking p 38 α and p 38 δ can Differentiate to Endothelial Cells , Smooth Muscle Cells , and Epithelial Cells

  2019influential citation
• Gender differences in the regulation of MLC20 phosphorylation and smooth muscle contraction in rat stomach

  2018cites this paper
• Beta-3 Adrenoceptor Signaling Pathways in Urothelial and Smooth Muscle Cells in the Presence of Succinate

  2018influential citation
• Spasmolytic effect of aqueous extract of Tagetes erecta L. flowers is mediated through calcium channel blockade on the guinea-pig ileum.

  2018cites this paper
• Spasmogenic and spasmolytic activities of Agastache mexicana ssp. mexicana and A. mexicana ssp. xolocotziana methanolic extracts on the guinea pig ileum.

  2017cites this paper
• Acetylcholine‐dependent upregulation of TASK‐1 channels in thalamic interneurons by a smooth muscle‐like signalling pathway

  2017influential citation
• Ca2+/calmodulin/MLCK pathway initiates, and RhoA/ROCK maintains, the internal anal sphincter smooth muscle tone.

  2017cites this paper
• PERSPECTIVES Neurogastroenterology and Motility Ca 2 (cid:2) /calmodulin/MLCK pathway initiates, and RhoA/ROCK maintains, the internal anal sphincter smooth muscle tone

  2017cites this paper
• Ethnopharmacological basis for antispasmodic, antidiarrheal and antiemetic activities of Ceratonia siliqua pods

  2017cites this paper
• The Effects of Rosmarinus officinalis ( Rosemary ) Aqueous Extract on Smooth Muscle Contractions in Isolated Rat Urinary Bladder

  2017cites this paper
• Calcium Sensitization Mechanisms in Gastrointestinal Smooth Muscles

  2016cites this paper
• Regulation of mitogen-activated protein kinase by protein kinase C and mitogen-activated protein kinase phosphatase-1 in vascular smooth muscle.

  2016cites this paper
• Transcriptomic and proteomic analyses of Amphiura filiformis arm tissue-undergoing regeneration.

  2015cites this paper
• ERK and p38MAPK pathways regulate myosin light chain phosphatase and contribute to Ca2+ sensitization of intestinal smooth muscle contraction

  2015cites this paper
• Le CD34 dans la réactivité du système respiratoire en contexte d'asthme allergique

  2015cites this paper
• Mechanism and role of calcium in excitation-mucus secretion coupling in human colonic epithelium

  2015cites this paper
• The role of the RhoA/ROCK pathway in gender-dependent differences in gastric smooth muscle contraction

  2015cites this paper
• Cortical actin regulation modulates vascular contractility and compliance in veins

  2015cites this paper
• Role of various kinases in muscarinic M3 receptor-mediated contraction of longitudinal muscle of rat colon

  2015cites this paper
• The implication of tone on airway responsiveness in vivo in mice and on the contractile capacity of airway smooth muscle

  2015influential citation
• Antispasmodic and myorelaxant effects of the flavoring agent methyl cinnamate in gut: potential inhibition of tyrosine kinase.

  2014cites this paper
• Pulmonary , gastrointestinal and urogenital pharmacology Antispasmodic and myorelaxant effects of the fl avoring agent methyl cinnamate in gut : Potential inhibition of tyrosine kinase

  2014cites this paper
• Activation of the EGFR/p38/JNK pathway by mitochondrial-derived hydrogen peroxide contributes to oxygen-induced contraction of ductus arteriosus

  2014cites this paper
• The Allosteric Modulating Effects of Dronedarone on Muscarinic Receptor Subtypes at a Novel Allosteric Binding Site

  2013cites this paper
• Gastric body cholinergic contractile signal transduction in M2 and M3 receptor knockout mice

  2013cites this paper
• Neuroprotective Evaluation of Tiliaamericana and Annonadiversifolia in the Neuronal Damage Induced by Intestinal Ischemia

  2013influential citation
• The roles of intrinsic disorder in protein interaction networks

  2013cites this paper
• The contribution of protein kinase C and CPI‐17 signaling pathways to hypercontractility in murine experimental colitis

  2012cites this paper
• Temporal analysis of vascular smooth muscle cell elasticity and adhesion reveals oscillation waveforms that differ with aging

  2012cites this paper
• MEKK1-MKK4-JNK-AP1 Pathway Negatively Regulates Rgs4 Expression in Colonic Smooth Muscle Cells

  2012cites this paper
• Regulation of Excitation-Contraction and Excitation-Transcription Coupling in Gastrointestinal Smooth Muscle by Caveolin-1

  2012cites this paper
• Cytokine-induced alterations of gastrointestinal motility in gastrointestinal disorders.

  2011cites this paper
• The Paradigm of G Protein Receptor Transactivation: A Mechanistic Definition and Novel Example

  2011cites this paper
• Signalling pathways responsible for the methylisogermabullone‐induced contraction of ileal longitudinal muscles

  2011cites this paper
• Relaxant effects of Schisandra chinensis and its major lignans on agonists-induced contraction in guinea pig ileum.

  2011cites this paper
• Spasmolytic activity of Rosmarinus officinalis L. involves calcium channels in the guinea pig ileum.

  2011cites this paper
• Kinase pathways underlying muscarinic activation of colonic longitudinal muscle

  2011cites this paper
• Endogenous purines as potential pharmacological targets to control myenteric neurotransmissions

  2011cites this paper
• A complex of CaV1.2/PKC is involved in muscarinic signaling in smooth muscle

  2010influential citation
• Inhibition of p38 MAPK-dependent bronchial contraction after ozone by corticosteroids

  2010cites this paper
• MEK modulates force-fluctuation-induced relengthening of canine tracheal smooth muscle

  2010cites this paper
• RhoA/Rho-kinase: pathophysiologic and therapeutic implications in gastrointestinal smooth muscle tone and relaxation.

  2010cites this paper
• The Inhibitory Effect of Eupatilin on the Intestinal Contraction Induced by Carbachol

  2010cites this paper
• Opportunities to Target Specific Contractile Abnormalities with Smooth Muscle Protein Kinase Inhibitors

  2010cites this paper
• Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter‐4 and increasing glucokinase

  2010cites this paper
• Chapter 1: roles of caldesmon in cell motility and actin cytoskeleton remodeling.

  2009influential citation
• Gain of new exons and promoters by lineage-specific transposable elements-integration and conservation event on CHRM3 gene

  2009cites this paper
• Intracellular signal transduction pathways in the regulation of fowl sperm motility: Evidence for the involvement of phosphatidylinositol 3‐kinase (PI3‐K) cascade

  2009cites this paper
• Curcumin eliminates leptin's effects on hepatic stellate cell activation via interrupting leptin signaling.

  2009cites this paper
• Curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating oxidative stress

  2009cites this paper
• Ca2+-independent contraction of longitudinal ileal smooth muscle is potentiated by a zipper-interacting protein kinase pseudosubstrate peptide.

  2009cites this paper
• Immunoglobulins from scleroderma patients inhibit the muscarinic receptor activation in internal anal sphincter smooth muscle cells.

  2009cites this paper
• Arecoline‐induced phosphorylated p53 and p21WAF1 protein expression is dependent on ATM/ATR and phosphatidylinositol‐3‐kinase in clone‐9 cells

  2009cites this paper
• Mitogen-Activated Protein Kinase Pathways Contribute to Hypercontractility and Increased Ca2+ Sensitization in Murine Experimental Colitis

  2009influential citation
• Mouse embryonic stem cells lacking p38alpha and p38delta can differentiate to endothelial cells, smooth muscle cells, and epithelial cells.

  2009cites this paper
• Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology

  2009cites this paper
• Heat shock protein 90 inhibitors protect and restore pulmonary endothelial barrier function.

  2008cites this paper
• Differential Coupling of M1 Muscarinic and α7 Nicotinic Receptors to Inhibition of Pemphigus Acantholysis*

  2008cites this paper
• Calcium Sensitization in Human Esophageal Muscle: Role for RhoA Kinase in Maintenance of Lower Esophageal Sphincter Tone

  2008influential citation
• Impaired acetylcholine-induced smooth muscle contraction in colitis involves altered calcium mobilization and AKT phosphorylation

  2008influential citation
• Comparative X-Ray study of galantamine and tacrine on the evacuatory function of rat gastrointestinal tract

  2008cites this paper
• Sub-plasmalemmal [Ca2+]i upstroke in myocytes of the guinea-pig small intestine evoked by muscarinic stimulation: IP3R-mediated Ca2+ release induced by voltage-gated Ca2+ entry

  2008cites this paper
• The Use of Occupation Isoboles for Analysis of a Response Mediated by Two Receptors: M2 and M3 Muscarinic Receptor Subtype-Induced Mouse Stomach Contractions

  2008cites this paper
• Intestinal chronic obstruction affects motor responsiveness of rat hypertrophic longitudinal and circular muscles

  2008cites this paper
• Role of MAPKs in angiotensin II-induced steroidogenesis in rat glomerulosa cells.

  2007cites this paper
• MAPK‐pathway activity, Lrrk2 G2019S, and Parkinson's disease

  2007cites this paper
• Characterization of protein kinase pathways responsible for Ca2+ sensitization in rat ileal longitudinal smooth muscle.

  2007cites this paper
• CD44, a signal receptor for the inhibition of the cytoadhesion of CD36-binding Plasmodium falciparum-infected erythrocytes by CSA-binding infected erythrocytes.

  2007cites this paper
• p38α MAP kinase‐deficient mouse embryonic stem cells can differentiate to endothelial cells, smooth muscle cells, and neurons

  2007cites this paper
• Upregulation of RGS4 and downregulation of CPI-17 mediate inhibition of colonic muscle contraction by interleukin-1beta.

  2007cites this paper
• Inhibition of Colonic Muscle Contraction by Interleukin-1

  2007cites this paper
• A minor role for Ca2+ sensitization in sustained contraction through activation of muscarinic receptor in circular muscle of rat distal colon

  2007influential citation
• Differential involvement of cytoskeleton and Rho-GTPases in growth - promoting effects of angiotensin II in rat adrenal glomerulosa cells.

  2006cites this paper
• Airway smooth muscle phenotype and function: interactions with current asthma therapies.

  2006cites this paper
• Altered responsiveness of the guinea‐pig isolated ileum to smooth muscle stimulants and to electrical stimulation after in situ ischemia

  2006cites this paper
• Imatinib inhibits spontaneous rhythmic contractions of human uterus and intestine.

  2006cites this paper
• Differential involvement of cytoskeleton and rho-guanosine 5'-triphosphatases in growth-promoting effects of angiotensin II in rat adrenal glomerulosa cells.

  2006cites this paper
• Calcium signalling in smooth muscle.

  2005cites this paper
• Flexible nets

  2005cites this paper
• Modulation of PGF2alpha- and hypoxia-induced contraction of rat intrapulmonary artery by p38 MAPK inhibition: a nitric oxide-dependent mechanism.

  2005cites this paper