The Maintenance of Epigenetic States by p53: The Guardian of the Epigenome

// Arnold J. Levine 1 and Benjamin Greenbaum 1 1 Institute for Advanced Study, Einstein Road, Princeton, N.J. Correspondence: Arnold J. Levine , email: // Keywords : TP53, virus, cancer, cell death, epigenetic stability Received : December 08, 2012, Accepted : December 10, 2012, Published : December 11, 2012 Commentary on: Leonova et al. p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs. PNAS, USA, 2012; in press.

• Publication year

  2012

• Venue

  OncoTarget

• Publication date

  2012-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.18632/ONCOTARGET.780PMID 23237909PMCID 3681489
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Interfaces Between Signal Transduction Pathways: IGF-1/mTor, p53 and the Parkinson Disease Pathway

  2012cited by this paper
• p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs

  2012cited by this paper
• Multiple roles of p53-related pathways in somatic cell reprogramming and stem cell differentiation.

  2012cited by this paper
• Aberrant Overexpression of Satellite Repeats in Pancreatic and Other Epithelial Cancers

  2011cited by this paper
• Molecular classification of prostate cancer using curated expression signatures

  2011cited by this paper
• Oligonucleotide Motifs That Disappear during the Evolution of Influenza Virus in Humans Increase Alpha Interferon Secretion by Plasmacytoid Dendritic Cells

  2011cited by this paper
• Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures

  2010cited by this paper
• Stem cell biology meets p53

  2009cited by this paper
• Patterns of Oligonucleotide Sequences in Viral and Host Cell RNA Identify Mediators of the Host Innate Immune System

  2009cited by this paper
• Patterns of Evolution and Host Gene Mimicry in Influenza and Other RNA Viruses

  2008cited by this paper
• Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

  2006cited by this paper
• Global loss of imprinting leads to widespread tumorigenesis in adult mice.

  2005cited by this paper
• Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

  2001cited by this paper
• Surfing the p53 network

  2000cited by this paper

• Repeats mimic pathogen-associated patterns across a vast evolutionary landscape

  2025cites this paper
• Decoding p53 tumor suppression: a crosstalk between genomic stability and epigenetic control?

  2024cites this paper
• ΔNp63 silencing, DNA methylation shifts, and epithelial-mesenchymal transition resulted from TAp63 genome editing in squamous cell carcinoma

  2023cites this paper
• Cancer: Evidence Consistent with Epigenetic Carcinogenesis

  2022cites this paper
• Repeats Mimic Immunostimulatory Viral Features Across a Vast Evolutionary Landscape

  2021cites this paper
• Overcoming the problem of the lack of an immune response to cancer: A possible haptogenic approach to cancer immunotherapy

  2021cites this paper
• p53: 800 million years of evolution and 40 years of discovery

  2020cites this paper
• Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia

  2020cites this paper
• Non-Random Selection of Cancer-Causing Mutations in Tissue-Specific Stem Cells Cause Cancer.

  2020cites this paper
• Comparative STAT3-Regulated Gene Expression Profile in Renal Cell Carcinoma Subtypes

  2019cites this paper
• Omics Approaches to Uncover Germline and Somatic Variation Underlying Inherited Sarcomagenesis

  2018cites this paper
• Epimutation and Cancer: Carcinogenesis Viewed as Error-Prone Inheritance of Epigenetic Information

  2018cites this paper
• Innate immune driven evolution via immunostimulatory RNA: Viruses that mimic hosts, tumors that mimic viruses

  2017cites this paper
• Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.

  2017cites this paper
• Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity

  2017cites this paper
• p53: master of life, death, and the epigenome

  2017cites this paper
• p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity

  2017cites this paper
• Genetic and Epigenetic Crosstalk Define TP53-Mediated Human Cancer Susceptibility

  2016influential citation
• P53 and the defenses against genome instability caused by transposons and repetitive elements

  2016cites this paper
• Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells

  2015cites this paper
• p53 binding to human genome: crowd control navigation in chromatin context

  2014cites this paper
• Cell Context Dependent p53 Genome-Wide Binding Patterns and Enrichment at Repeats

  2014cites this paper
• Heritable one-hit events defining cancer prevention?

  2013cites this paper
• Recent discoveries in the cycling , growing and aging of the p 53 field

  2013cites this paper
• Targeting nucleocytoplasmic transport in cancer therapy

  2013cites this paper
• Pancreatic cancer screening: what we do and do not know.

  2013cites this paper
• Recent discoveries in the cycling, growing and aging of the p53 field

  2012cites this paper