Metastasis-inducing dna regulates the expression of the osteopontin gene by binding the transcription factor Tcf-4.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Cancer Research

• Publication date

  2002-04-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1100/TSW.2002.238PMID 11454716
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• beta-catenin expression in primary and metastatic colorectal carcinoma.

  1999cited by this paper
• The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors

  1999influential reference
• β‐catenin expression in primary and metastatic colorectal carcinoma

  1999cited by this paper
• Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium.

  1999cited by this paper
• Co‐expression of osteopontin and CD44v9 in gastric cancer

  1998cited by this paper
• Osteopontin expression in a group of lymph node negative breast cancer patients

  1998cited by this paper
• HMG box containing transcription factors in lymphocyte differentiation.

  1998cited by this paper
• Identification of c-MYC as a target of the APC pathway.

  1998cited by this paper
• How a Growth Control Path Takes a Wrong Turn to Cancer

  1998cited by this paper
• Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

  1998cited by this paper
• Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma

  1997cited by this paper
• Characterization of the interactions of α-catenin with α-actinin and β-catenin / plakoglobin

  1997cited by this paper
• Interaction between estradiol and growth factors in the regulation of specific gene expression in MCF-7 human breast cancer cells.

  1997cited by this paper
• Characterization of the interactions of alpha-catenin with alpha-actinin and beta-catenin/plakoglobin.

  1997cited by this paper
• Ectopic activation of lymphoid high mobility group‐box transcription factor TCF‐1 and overexpression in colorectal cancer cells

  1997cited by this paper
• Transcriptional Down-regulation of the Metastasis-inducing S100A4 (p9Ka) in Benign but Not in Malignant Rat Mammary Epithelial Cells by GC-factor*

  1997cited by this paper
• Two separate mechanisms for ligand-independent activation of the estrogen receptor.

  1997cited by this paper
• Isolation of and effector for metastasis-inducing DNAs from a human metastatic carcinoma cell line

  1997cited by this paper
• Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

  1997cited by this paper
• The identification of metastasis-related gene products in a rodent mammary tumour model.

  1996cited by this paper
• The identification of osteopontin as a metastasis-related gene product in a rodent mammary tumour model.

  1996cited by this paper
• Characterization of the Rat Osteopontin Gene

  1995cited by this paper
• Genetic and biochemical dissection of protein linkages in the cadherin-catenin complex.

  1995cited by this paper
• Wnt-4 expression induces a pregnancy-like growth pattern in reconstituted mammary glands in virgin mice.

  1995cited by this paper
• Structural basis for DNA bending by the architectural transcription factor LEF-1.

  1995cited by this paper
• Structural basis for DNA bending by the architectural transcription factor LEF-1

  1995cited by this paper
• Osteopontin (OPN) may facilitate metastasis by protecting cells from macrophage NO-mediated cytotoxicity: evidence from cell lines down-regulated for OPN expression by a targeted ribozyme

  1995cited by this paper
• Induction of metastatic ability in a stably diploid benign rat mammary epithelial cell line by transfection with DNA from human malignant breast carcinoma cell lines.

  1994cited by this paper
• Specific reduction in osteopontin synthesis by antisense RNA inhibits the tumorigenicity of transformed Rat1 fibroblasts.

  1994cited by this paper
• Reduced malignancy of ras-transformed NIH 3T3 cells expressing antisense osteopontin RNA.

  1994cited by this paper
• Osteopontin: a protein with diverse functions

  1993cited by this paper
• Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast

  1993cited by this paper
• Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system.

  1993cited by this paper
• Induction of the metastatic phenotype by transfection of a benign rat mammary epithelial cell line with the gene for p9Ka, a rat calcium-binding protein, but not with the oncogene EJ-ras-1.

  1993cited by this paper
• Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation.

  1991cited by this paper
• A genetic basis for metastasis.

  1991cited by this paper
• Identification and cloning of TCF‐1, a T lymphocyte‐specific transcription factor containing a sequence‐specific HMG box.

  1991cited by this paper
• Different malignant phenotypes induced in a stable, subdiploid, benign epithelial clone by DNA transfection.

  1991cited by this paper
• TCF-1, a T cell-specific transcription factor of the HMG box family, interacts with sequence motifs in the TCR beta and TCR delta enhancers.

  1991cited by this paper
• Cloning of murine TCF-1, a T cell-specific trans cription factor interacting with functional motifs in the CD3ε and T cell receptor α enhancers.

  1991cited by this paper
• Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers

  1991cited by this paper
• The pattern of metastases in human breast cancer: methodological aspects and influence of prognostic factors.

  1990cited by this paper
• A novel sequence-specific DNA binding protein which interacts with three regularly spaced direct repeats of the CCCTC-motif in the 5'-flanking sequence of the chicken c-myc gene.

  1990cited by this paper
• Generation of metastatic variants by transfection of a nonmetastatic rat mammary epithelial cell line with DNA from a metastatic rat mammary cell line.

  1990cited by this paper
• Transcription initiation from the dihydrofolate reductase promoter is positioned by HIP1 binding at the initiation site

  1990cited by this paper
• Simultaneous transfer of tumorigenic and metastatic phenotypes by transfection with genomic DNA from a human cutaneous squamous cell carcinoma

  1988cited by this paper
• Molecular genetics of metastasis.

  1988cited by this paper
• Selective enhancement of metastatic capacity in mouse bladder carcinoma cells after transfection with dna from liver metastases of human colon carcinoma

  1988cited by this paper
• Loss of production of myoepithelial cells and basement membrane proteins but retention of response to certain growth factors and hormones by a new malignant human breast cancer cell strain.

  1985cited by this paper
• Phenotypic instability of rat mammary tumor epithelial cells.

  1983cited by this paper
• Establishment and characterization of three new continuous cell lines derived from human breast carcinomas.

  1978cited by this paper
• A human cell line from a pleural effusion derived from a breast carcinoma.

  1973cited by this paper

• Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer

  2022cites this paper
• The β-catenin/TCF-4 pathway regulates the expression of OPN in human osteoarthritic chondrocytes

  2020cites this paper
• Role of osteopontin in lung cancer evolution and heterogeneity.

  2017cites this paper
• Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancer

  2016cites this paper
• The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution

  2015cites this paper
• Mechanisms of osteopontin-mediated effects on chronic hepatic inflammation and cancer

  2015cites this paper
• Post-Operative Plasma Osteopontin Predicts Distant Metastasis in Human Colorectal Cancer

  2015cites this paper
• Title Post-operative plasma osteopontin predicts distant metastasisin human colorectal cancer

  2015cites this paper
• Transcriptome and proteome of human hepatocellular carcinoma reveal shared metastatic pathways with significant genes

  2015cites this paper
• miR-139 regulates the proliferation and invasion of hepatocellular carcinoma through the WNT/TCF-4 pathway.

  2014cites this paper
• A Regulatory Loop between β-Catenin and Extra-cellular Matrix Components during the Proliferative Phase of Cutaneous Wound Healing

  2014cites this paper
• Potentiation of colon cancer susceptibility in mice by colonic epithelial PPAR-δ/β overexpression.

  2014cites this paper
• Upregulation of T‐cell factor‐4 isoform‐responsive target genes in hepatocellular carcinoma

  2013cites this paper
• DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin

  2012cites this paper
• Wnt–β-catenin–Tcf-4 signalling-modulated invasiveness is dependent on osteopontin expression in breast cancer

  2011cites this paper
• RAN GTPase as a target for cancer therapy: Ran binding proteins.

  2011cites this paper
• The Wnt/beta‐catenin pathway is activated during advanced arterial aging in humans

  2011influential citation
• Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression

  2010cites this paper
• Total synthesis of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin: powerful new inhibitors of beta-catenin/TCF4- and E2F-mediated gene transcription.

  2010cites this paper
• The Yin and Yang of vitamin D receptor (VDR) signaling in neoplastic progression: Operational networks and tissue-specific growth control

  2010cites this paper
• Expression and function of osteopontin variants in HCV-related liver disease and hepatocellular carcinoma.

  2010cites this paper
• Non-Canonical Wnt Signaling and N-Cadherin Related β-Catenin Signaling Play a Role in Mechanically Induced Osteogenic Cell Fate

  2009cites this paper
• Identification of genes differentially expressed between benign and osteopontin transformed rat mammary epithelial cells

  2009cites this paper
• Vitamin D receptor modulates the neoplastic phenotype through antagonistic growth regulatory signals

  2009influential citation
• Synthesis of A83586C analogs with potent anticancer and beta-catenin/ TCF4/osteopontin inhibitory effects and insights into how A83586C modulates E2Fs and pRb.

  2009cites this paper
• The metastasis-associated anterior gradient 2 protein is correlated with poor survival of breast cancer patients.

  2009cites this paper
• Role of osteopontin in cellular signaling and metastatic phenotype.

  2008cites this paper
• Osteopontin as a target for cancer therapy.

  2008cites this paper
• Agelastatin A: a novel inhibitor of osteopontin-mediated adhesion, invasion, and colony formation

  2008influential citation
• RAN GTPase is an effector of the invasive/metastatic phenotype induced by osteopontin

  2008cites this paper
• The role of LEF/TCF factors in neoplastic transformation.

  2008cites this paper
• Osteopontin: regulation in tumor metastasis

  2008cites this paper
• Polyomavirus Middle T Antigen Induces the Transcription of Osteopontin, a Gene Important for the Migration of Transformed Cells

  2008cites this paper
• Metastasis: a current perspective

  2008cites this paper
• Is there a genetic signature for liver metastasis in colorectal cancer?

  2007cites this paper
• OSTEOPONTIN AND CELL ADHESION: ROLE OF POST-TRANSLATIONAL MODIFICATIONS AND THE C-TERMINAL REGION by

  2007cites this paper
• sFAS/sFASL and sMMP-7: New soluble markers of prognosis and response to therapy in advanced colorectal cancer

  2007cites this paper
• Osteopontin gene expression determines spontaneous metastatic performance of orthotopic human breast cancer xenografts.

  2007cites this paper
• Interaction between Transcription Factor, Basal Transcription Factor 3, and the NH2-Terminal Domain of Human Estrogen Receptor α

  2007cites this paper
• Bioreactor Expansion of Human Adult Bone Marrow‐Derived Mesenchymal Stem Cells

  2006cites this paper
• BRCA1 Suppresses Osteopontin-mediated Breast Cancer*

  2006cites this paper
• An osteopontin splice variant induces anchorage independence in human breast cancer cells

  2006cites this paper
• Identification of apolipoprotein D as a novel inhibitor of osteopontin-induced neoplastic transformation.

  2006cites this paper
• Stathmin overexpression cooperates with p53 mutation and osteopontin overexpression, and is associated with tumour progression, early recurrence, and poor prognosis in hepatocellular carcinoma

  2006cites this paper
• The regulation and role of osteopontin in malignant transformation and cancer.

  2006cites this paper
• Molecular Connection Between Breast Cancer Proliferation and Metastasis Mediated by Akt Kinase

  2006cites this paper
• A Molecular Connection Between Cancer Proliferation and Metastasis Mediated by Akt Kinase

  2006cites this paper
• Aberrant expressions of annexin A10 short isoform, osteopontin and alpha-fetoprotein at chromosome 4q cooperatively contribute to progression and poor prognosis of hepatocellular carcinoma.

  2005cites this paper
• Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells.

  2005cites this paper
• TIS7 Regulation of the β-Catenin/Tcf-4 Target Gene Osteopontin (OPN) Is Histone Deacetylase-dependent*

  2005cites this paper
• Total Synthesis and Mechanism of Action Studies on the Antitumor Alkaloid (-)-Agelastatin A

  2005cites this paper
• Fluid Shear Stress Induces β-Catenin Signaling in Osteoblasts

  2004cites this paper
• Ets Gene PEA3 Cooperates with β-Catenin-Lef-1 and c-Jun in Regulation of Osteopontin Transcription*

  2004cites this paper
• Differential Osteopontin Expression in Phenotypically Distinct Subclones of Murine Breast Cancer Cells Mediates Metastatic Behavior*

  2004cites this paper
• Beta-catenin regulates the gene of MMP-26, a novel metalloproteinase expressed both in carcinomas and normal epithelial cells.

  2004cites this paper
• Transcriptional regulation of osteopontin and the metastatic phenotype: Evidence for a Ras-activated enhancer in the human OPN promoter

  2004cites this paper
• β-Catenin regulates the gene of MMP-26, a novel matrix metalloproteinase expressed both in carcinomas and normal epithelial cells

  2004cites this paper
• RESEARCH REVIEW The Role of Osteopontin in Tumor Metastasis

  2004cites this paper
• The role of Osteopontin in tumor metastasis.

  2004cites this paper
• Fluid shear stress induces beta-catenin signaling in osteoblasts.

  2004cites this paper
• Identification of metastasis‐associated proteins in a human tumor metastasis model using the mass‐mapping technique

  2004cites this paper
• Osteopontin expression correlates with adhesive and metastatic potential in metastasis-inducing DNA-transfected rat mammary cell lines

  2004cites this paper
• Overexpression of osteopontin is associated with intrahepatic metastasis, early recurrence, and poorer prognosis of surgically resected hepatocellular carcinoma

  2003cites this paper
• Growth Factor Signaling Induces Metastasis Genes in Transformed Cells: Molecular Connection between Akt Kinase and Osteopontin in Breast Cancer

  2003cites this paper
• Association of hTcf-4 gene expression and mutation with clinicopathological characteristics of hepatocellular carcinoma.

  2002cites this paper
• Regulation of epithelial cell migration and tumor formation by beta-catenin signaling.

  2002cites this paper
• Prognostic significance of the metastasis-associated protein osteopontin in human breast cancer.

  2002cites this paper
• Differential Modulation of Transcriptional Activity of Estrogen Receptors by Direct Protein-Protein Interactions with the T Cell Factor Family of Transcription Factors*

  2001cites this paper