Functional Interactions in Transcription and Splicing of Ewing’s Sarcoma

No abstract is available for this paper.

• Publication year

  2013

• Venue

  International Scholarly Research Notices

• Publication date

  2013-07-22

• Fields of study

  Biology

• Identifiers
  DOI 10.5402/2013/184063
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• The Transcriptional Repressor

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• Disorder structural predictions of the native EWS and its oncogenic fusion proteins in rapport with the function

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• The RNA Pol II sub-complex hsRpb4/7 is required for viability of multiple human cell lines

  2012cited by this paper
• I and J

  2012influential reference
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  2011cited by this paper
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  2011cited by this paper
• The Ewing sarcoma protein regulates DNA damage-induced alternative splicing.

  2011cited by this paper
• A fraction of the transcription factor TAF15 participates in interactions with a subset of the spliceosomal U1 snRNP complex.

  2011cited by this paper
• A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs

  2011cited by this paper
• Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence.

  2011cited by this paper
• Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma

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• Promiscuous partnerships in Ewing's sarcoma.

  2011influential reference
• Downstream EWS/FLI1 - upstream Ewing's sarcoma

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• Oncogenic Partnerships: EWS-FLI1 Protein Interactions Initiate Key Pathways of Ewing's Sarcoma

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• Cotranscriptional exon skipping in the genotoxic stress response

  2010cited by this paper
• Ewing Tumors That Do Not Overexpress BMI-1 Are a Distinct Molecular Subclass with Variant Biology: A Report from the Children's Oncology Group

  2010cited by this paper
• Mesenchymal Stem Cells and the Origin of Ewing's Sarcoma

  2010cited by this paper
• FOXO1 is a direct target of EWS-Fli1 oncogenic fusion protein in Ewing's sarcoma cells.

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• An atlas of combinatorial transcriptional regulation in mouse and man.

  2010cited by this paper
• Identification of a self-association domain in the Ewing's sarcoma protein: a novel function for arginine-glycine-glycine rich motifs?

  2010cited by this paper
• Analysis of Ewing sarcoma (EWS)-binding proteins: interaction with hnRNP M, U, and RNA-helicases p68/72 within protein-RNA complexes.

  2009cited by this paper
• In vitro interaction between the N-terminus of the Ewing’s sarcoma protein and the subunit of RNA polymerase II hsRPB7

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• Induced ncRNAs Allosterically Modify RNA Binding Proteins in cis to Inhibit Transcription

  2008cited by this paper
• Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development.

  2007cited by this paper
• Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteins

  2007cited by this paper
• TLS, EWS and TAF15: a model for transcriptional integration of gene expression.

  2006cited by this paper
• Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A.

  2006cited by this paper
• Γ and B

  2004cited by this paper
• Cooperative Interaction of EWS with CREB-binding Protein Selectively Activates Hepatocyte Nuclear Factor 4-mediated Transcription*

  2003cited by this paper
• Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion protein

  2003cited by this paper
• Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method

  2002cited by this paper
• Interaction of the EWS NH2 terminus with BARD1 links the Ewing's sarcoma gene to a common tumor suppressor pathway.

  2002cited by this paper
• An hsRPB4/7-dependent yeast assay for trans-activation by the EWS oncogene

  2001cited by this paper
• The Ewing's sarcoma gene product functions as a transcriptional activator.

  2001influential reference
• Oncogenic TLS/ERG and EWS/Fli-1 fusion proteins inhibit RNA splicing mediated by YB-1 protein.

  2001influential reference
• The Splicing Factor U1C Represses EWS/FLI-mediated Transactivation*

  2000cited by this paper
• EWS·Fli-1 Fusion Protein Interacts with Hyperphosphorylated RNA Polymerase II and Interferes with Serine-Arginine Protein-mediated RNA Splicing*

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• Modification of EWS/WT1 functional properties by phosphorylation.

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• Tyrosine kinase Pyk2 mediates G-protein-coupled receptor regulation of the Ewing sarcoma RNA-binding protein EWS.

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• Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II

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• The EWS/ATF1 fusion protein contains a dispersed activation domain that functions directly

  1998cited by this paper
• EWS, but Not EWS-FLI-1, Is Associated with Both TFIID and RNA Polymerase II: Interactions between Two Members of the TET Family, EWS and hTAFII68, and Subunits of TFIID and RNA Polymerase II Complexes

  1998cited by this paper
• The Transcriptional Repressor ZFM1 Interacts with and Modulates the Ability of EWS to Activate Transcription*

  1998cited by this paper
• The Prooncoprotein EWS Binds Calmodulin and Is Phosphorylated by Protein Kinase C through an IQ Domain*

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• RNA helicase A mediates association of CBP with RNA polymerase II.

  1997cited by this paper
• Dimerization of the TATA Binding Protein (*)

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• The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains.

  1994cited by this paper
• Genomic structure of the EWS gene and its relationship to EWSR1, a site of tumor-associated chromosome translocation.

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• and as an in

  year unknowncited by this paper

• Structure-Function Based Molecular Relationships in Ewing's Sarcoma

  2015cites this paper