Modulation of blood oxylipin levels by long-chain omega-3 fatty acid supplementation in hyper- and normolipidemic men.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Prostaglandins, Leukotrienes and Essential Fatty Acids

• Publication date

  2014-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.plefa.2013.12.008PMID 24411718PMCID PMC4130704
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis

  2013cited by this paper
• Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men.

  2013cited by this paper
• Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health.

  2013cited by this paper
• Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation.

  2012cited by this paper
• Basal omega-3 fatty acid status affects fatty acid and oxylipin responses to high-dose n3-HUFA in healthy volunteers[S]

  2012cited by this paper
• Effect of cytochrome P450-dependent epoxyeicosanoids on Ristocetin-induced thrombocyte aggregation

  2012cited by this paper
• Quantitative profiling of oxylipins through comprehensive LC-MS/MS analysis: application in cardiac surgery

  2012cited by this paper
• Elevated blood pressure in cytochrome P4501A1 knockout mice is associated with reduced vasodilation to omega-3 polyunsaturated fatty acids.

  2012cited by this paper
• Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes

  2012cited by this paper
• Omega-3 fatty acid supplementation and cardiovascular disease

  2012cited by this paper
• CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease?

  2011cited by this paper
• Investigation of human exposure to triclocarban after showering and preliminary evaluation of its biological effects.

  2011cited by this paper
• The Human Serum Metabolome

  2011cited by this paper
• Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events.

  2011cited by this paper
• Analysis of omega-3 and omega-6 fatty acid-derived lipid metabolite formation in human and mouse blood samples.

  2011cited by this paper
• Enhanced increase of omega-3 index in response to long-term n-3 fatty acid supplementation from triacylglycerides versus ethyl esters

  2011cited by this paper
• Arachidonic Acid-metabolizing Cytochrome P450 Enzymes Are Targets of ω-3 Fatty Acids*

  2010cited by this paper
• Cytochrome P450-dependent metabolism of omega-6 and omega-3 long-chain polyunsaturated fatty acids.

  2010influential reference
• Cytochrome P450-dependent metabolism of ω-6 and ω-3 long-chain polyunsaturated fatty acids

  2010cited by this paper
• Detection of omega-3 oxylipins in human plasma and response to treatment with omega-3 acid ethyl esters[S]

  2010cited by this paper
• Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids[S]

  2010cited by this paper
• Quantitative profiling method for oxylipin metabolome by liquid chromatography electrospray ionization tandem mass spectrometry.

  2009cited by this paper
• An integrated omics analysis of eicosanoid biology.

  2009cited by this paper
• alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans.

  2009cited by this paper
• Metabolism of eicosapentaenoic and docosahexaenoic acids by recombinant human cytochromes P450.

  2008cited by this paper
• The opposing effects of n-3 and n-6 fatty acids.

  2008cited by this paper
• Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements.

  2007cited by this paper
• Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids.

  2006cited by this paper
• Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults.

  2005cited by this paper
• Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles.

  2005cited by this paper
• Soluble epoxide hydrolase is a therapeutic target for acute inflammation.

  2005cited by this paper
• The Omega-3 Index: a new risk factor for death from coronary heart disease?

  2004cited by this paper
• Cytochrome P450 pathways of arachidonic acid metabolism

  2002cited by this paper
• Lipoxygenases: Occurrence, Functions, Catalysis, and Acquisition of Substrate*

  1999cited by this paper
• Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes.

  1998cited by this paper
• Incorporation of n-3 fatty acids into plasma lipid fractions, and erythrocyte membranes and platelets during dietary supplementation with fish, fish oil, and docosahexaenoic acid-rich oil among healthy young men

  1997cited by this paper

• Effects of Antarctic krill oil on lipid profiles and SPM levels in rats over time.

  2026cites this paper
• Altered Plasma Endocannabinoids and Oxylipins in Adolescents with Major Depressive Disorders: A Case–Control Study

  2026cites this paper
• Quantification of esterified oxylipins following HILIC-fractionation of lipid classes

  2025cites this paper
• Randomized dose-response trial of n-3 fatty acids in hormone receptor negative breast cancer survivors-impact on breast adipose oxylipin and DNA methylation patterns.

  2025cites this paper
• An Optimized Ex Vivo n–3 PUFA Supplementation Strategy for Primary Human Macrophages Shows That DHA Suppresses Prostaglandin E2 Formation

  2024cites this paper
• Optimal Pair Matching Combined with Machine Learning Predicts a Significant Reduction in Myocardial Infarction Risk in African Americans Following Omega-3 Fatty Acid Supplementation

  2024cites this paper
• Optimal Pair Matching Combined with Machine Learning Predicts that Omega-3 Fatty Acid Supplementation Markedly Reduces the Risk of Myocardial Infarction in African Americans

  2024cites this paper
• Stearidonic acid improves eicosapentaenoic acid status: studies in humans and cultured hepatocytes

  2024cites this paper
• In vitro digestion and culture in Caco‐2 cells to assess the bioavailability of fatty acids: A case study in meat matrix enriched with ω‐3 microcapsules

  2024cites this paper
• Randomized dose-response trial of n-3 fatty acids in hormone receptor negative breast cancer survivors– impact on breast adipose oxylipin and DNA methylation patterns

  2024cites this paper
• Influence of Dietary n-3 Long Chain Polyunsaturated Fatty Acid Intake on Oxylipins in Erythrocytes of Women with Rheumatoid Arthritis

  2023cites this paper
• Prevention of colitis-induced liver oxidative stress and inflammation in a transgenic mouse model with increased omega-3 polyunsaturated fatty acids

  2023cites this paper
• Oxylipin status, before and after LC n-3 PUFA supplementation, has little relationship with skeletal muscle biology in older adults at risk of sarcopenia.

  2023cites this paper
• A walnut-enriched diet for 2 years changes the serum oxylipin profile in healthy older persons.

  2023cites this paper
• Effects of conventionally treated and ozonated wastewater on the damselfly larva oxylipidome in response to on-site exposure.

  2022cites this paper
• Lipid Serum Profiling of Boar-Tainted and Untainted Pigs Using GC×GC–TOFMS: An Exploratory Study

  2022cites this paper
• Pharmaceutical nanoformulation strategies to spatiotemporally manipulate oxidative stress for improving cancer therapies — exemplified by polyunsaturated fatty acids and other ROS-modulating agents

  2022cites this paper
• Eicosanoids in inflammation in the blood and the vessel

  2022influential citation
• The FADS1 rs174550 Genotype Modifies the n‐3 and n‐6 PUFA and Lipid Mediator Responses to a High Alpha‐Linolenic Acid and High Linoleic Acid Diets

  2022cites this paper
• 12,13-diHOME as a new therapeutic target for metabolic diseases.

  2021cites this paper
• Dynamic Role of Phospholipases A2 in Health and Diseases in the Central Nervous System

  2021cites this paper
• Disentangling the Molecular Mechanisms of the Antidepressant Activity of Omega-3 Polyunsaturated Fatty Acid: A Comprehensive Review of the Literature

  2021cites this paper
• APOE Genotype Modifies the Plasma Oxylipin Response to Omega-3 Polyunsaturated Fatty Acid Supplementation in Healthy Individuals

  2021cites this paper
• Exploiting oxidized lipids and the lipid‐binding GPCRs against cardiometabolic diseases

  2020cites this paper
• Effect of dietary EPA and DHA on murine blood and liver fatty acid profile and liver oxylipin pattern depending on high and low dietary n6-PUFA.

  2020cites this paper
• Harmonized procedures lead to comparable quantification of total oxylipins across laboratories

  2020cites this paper
• Profiling of Endogenous and Gut Microbial Metabolites to Indicate Metabotype-Specific Dietary Responses: A Systematic Review.

  2020cites this paper
• Oxylipin profiling in endothelial cells in vitro - Effects of DHA and hydrocortisone upon an inflammatory challenge.

  2019cites this paper
• Direct and indirect effects of lipids on microglia function.

  2019cites this paper
• Metabolism of polyunsaturated fatty acids and their oxylipins

  2019cites this paper
• Plasma oxylipins respond in a linear dose-response manner with increased intake of EPA and DHA: results from a randomized controlled trial in healthy humans.

  2019cites this paper
• The proposed systemic thermogenic metabolites succinate and 12,13-diHOME are inversely associated with adiposity and related metabolic traits: evidence from a large human cross-sectional study

  2019cites this paper
• Reversed phase UHPLC/ESI-MS determination of oxylipins in human plasma: a case study of female breast cancer

  2019cites this paper
• Oxylipin Profiling of Alzheimer’s Disease in Nondiabetic and Type 2 Diabetic Elderly

  2019cites this paper
• Dietary omega-3 PUFA improved tubular function after ischemia induced acute kidney injury in mice but did not attenuate impairment of renal function.

  2019cites this paper
• Lipidomic methodologies for biomarkers of chronic inflammation in nutritional research: ω-3 and ω-6 lipid mediators.

  2019cites this paper
• Spectrum evaluation‐assisted eicosanoid metabolomics for global eicosanoid profiling in human vascular endothelial cells

  2018cites this paper
• Effects of a 12-week high-α-linolenic acid intervention on EPA and DHA concentrations in red blood cells and plasma oxylipin pattern in subjects with a low EPA and DHA status.

  2018cites this paper
• Effect of Omega-3 Fatty Acid Supplementation on Oxylipins in a Routine Clinical Setting

  2018cites this paper
• Anti-inflammatory effects of α-linolenic acid in M1-like macrophages are associated with enhanced production of oxylipins from α-linolenic and linoleic acid.

  2018cites this paper
• Dietary ALA, EPA and DHA have distinct effects on oxylipin profiles in female and male rat kidney, liver and serum.

  2018cites this paper
• Intra-individual variance of the human plasma oxylipin pattern: Low inter-day variability in fasting blood samples: Versus high variability during the day

  2018cites this paper
• Dietary Docosahexaenoic Acid and trans-10, cis-12-Conjugated Linoleic Acid Differentially Alter Oxylipin Profiles in Mouse Periuterine Adipose Tissue

  2017cites this paper
• Alterations of specific lipid groups in serum of obese humans: a review

  2017cites this paper
• Effects of omega-3 fatty acid supplementation on the pattern of oxylipins: a short review about the modulation of hydroxy-, dihydroxy-, and epoxy-fatty acids.

  2017cites this paper
• Marine Lipids on Cardiovascular Diseases and Other Chronic Diseases Induced by Diet: An Insight Provided by Proteomics and Lipidomics

  2017cites this paper
• A diet rich in omega-3 fatty acids enhances expression of soluble epoxide hydrolase in murine brain.

  2017cites this paper
• Modulation of the endogenous omega-3 fatty acid and oxylipin profile in vivo—A comparison of the fat-1 transgenic mouse with C57BL/6 wildtype mice on an omega-3 fatty acid enriched diet

  2017cites this paper
• The future for long chain n-3 PUFA in the prevention of coronary heart disease: do we need to target non-fish-eaters?

  2017cites this paper
• Dietary modulation of oxylipins in cardiovascular disease and aging.

  2017cites this paper
• Bioavailability of Dietary Omega-3 Fatty Acids Added to a Variety of Sausages in Healthy Individuals

  2017cites this paper
• Effect of DHA supplementation on oxylipin levels in plasma and immune cell stimulated blood.

  2017influential citation
• Effects of Mediterranean Diet on the Metabolome

  2016cites this paper
• Effects of docosahexaenoic acid supplementation on PUFA levels in red blood cells and plasma.

  2016cites this paper
• Influence of weight reduction on blood levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and oxylipins in obese subjects.

  2016influential citation
• Divergent shifts in lipid mediator profile following supplementation with n‐3 docosapentaenoic acid and eicosapentaenoic acid

  2016cites this paper
• Influence of four weeks of n-3 polyunsaturated fatty acid supplementation on fat metabolism during prolonged exercise

  2016cites this paper
• A lipidomic analysis approach in patients undergoing lipoprotein apheresis.

  2016cites this paper
• Dietary flax oil rich in α-linolenic acid reduces renal disease and oxylipin abnormalities, including formation of docosahexaenoic acid derived oxylipins in the CD1-pcy/pcy mouse model of nephronophthisis.

  2015cites this paper
• Systematic metabolomic analysis of eicosanoids after omega-3 polyunsaturated fatty acid supplementation by a highly specific liquid chromatography-tandem mass spectrometry-based method.

  2015cites this paper
• Profiling the Oxylipin and Endocannabinoid Metabolome by UPLC-ESI-MS/MS in Human Plasma to Monitor Postprandial Inflammation

  2015cites this paper
• Whatever Happened to the Epoxyeicosatrienoic Acid-Like Endothelium-Derived Hyperpolarizing Factor? The Identification of Novel Classes of Lipid Mediators and Their Role in Vascular Homeostasis

  2015cites this paper
• The Pharmacology of the Cytochrome P450 Epoxygenase/Soluble Epoxide Hydrolase Axis in the Vasculature and Cardiovascular Disease

  2014cites this paper
• ncrease of EPA-derived hydroxy , epoxy and dihydroxy fatty acid evels in human plasma after a single dose of long-chain omega-3 UFA an

  2014cites this paper
• The Pharmacology of the Cytochrome P 450 Epoxygenase / Soluble Epoxide Hydrolase Axis in the Vasculature and Cardiovascular Disease

  2014cites this paper
• Comparison of the effects of long-chain omega-3 fatty acid supplementation on plasma levels of free and esterified oxylipins.

  2014cites this paper
• ω-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer.

  2014cites this paper
• Increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acid levels in human plasma after a single dose of long-chain omega-3 PUFA.

  2014cites this paper
• Prostaglandins and Other Lipid Mediators omparison of the effects of long-chain omega-3 fatty acid upplementation on plasma levels of free and esterified oxylipins ils

  2014cites this paper
• High-fat meals rich in EPA plus DHA compared with DHA only have differential effects on postprandial lipemia and plasma 8-isoprostane F2α concentrations relative to a control high–oleic acid meal: a randomized controlled trial

  2014cites this paper
• Determining the fatty acid composition in plasma and tissues as fatty acid methyl esters using gas chromatography – a comparison of different derivatization and extraction procedures.

  2014cites this paper
• PHARMREV007781 1106..1140

  2014cites this paper
• postprandial lipemia and plasma 8-isoprostane F 2 a concentrations relative to a control high – oleic acid meal : a randomized controlled trial

  2014cites this paper
• Oxylipins in human plasma – method development and dietary effects on levels

  2014influential citation
• Quantitation of oxylipins in biological samples, focusing on plasma and urine.

  year unknowncites this paper