IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2010-09-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1012977107PMID 20876105PMCID PMC2955119
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pattern recognition receptors and inflammation.

  2010cited by this paper
• Faculty Opinions recommendation of IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors.

  2010influential reference
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  2010cited by this paper
• IκBζ regulates TH17 development by cooperating with ROR nuclear receptors

  2010cited by this paper
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  2010cited by this paper
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  2009cited by this paper
• In vitro and in vivo differentiated effector CD8 T cells display divergent histone acetylation patterns within the Ifng locus.

  2009cited by this paper
• Poly I:C-Induced Activation of NK Cells by CD8α+ Dendritic Cells via the IPS-1 and TRIF-Dependent Pathways1

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• A Novel Role for IκBζ in the Regulation of IFNγ Production

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• Fcgamma receptors as regulators of immune responses.

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• Evolutionary struggles between NK cells and viruses

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• Crucial roles of binding sites for NF-κB and C/EBPs in IκB-ζ-mediated transcriptional activation

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• Crucial roles of binding sites for NF-kappaB and C/EBPs in IkappaB-zeta-mediated transcriptional activation.

  2007cited by this paper
• Genetic analysis of resistance to viral infection

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  2006cited by this paper
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  2006cited by this paper
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• NK cell recognition.

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• Histone hyperacetylated domains across the Ifng gene region in natural killer cells and T cells.

  2005cited by this paper
• Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta.

  2004influential reference
• T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells.

  2004cited by this paper
• Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ

  2004cited by this paper
• Synergy of IL-12 and IL-18 for IFN-γ Gene Expression: IL-12-Induced STAT4 Contributes to IFN-γ Promoter Activation by Up-Regulating the Binding Activity of IL-18-Induced Activator Protein 11

  2002cited by this paper
• Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1.

  2002cited by this paper
• TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes

  2002cited by this paper
• Signalling: STATs: transcriptional control and biological impact

  2002cited by this paper
• A Novel IκB Protein, IκB-ζ, Induced by Proinflammatory Stimuli, Negatively Regulates Nuclear Factor-κB in the Nuclei*

  2001cited by this paper
• Interleukin-18 regulates both Th1 and Th2 responses.

  2001influential reference
• A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei.

  2001cited by this paper
• A novel transcription factor, T-bet, directs Th1 lineage commitment.

  2000cited by this paper
• Mucosa-Specific Targets for Regulation of IFN-γ Expression: Lamina Propria T Cells Use Different cis-Elements than Peripheral Blood T Cells to Regulate Transactivation of IFN-γ Expression1

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• Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

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• Single-cell RNA-seq reveals the immune profile changes in patients with diarrhoeal-irritable bowel syndrome.

  2025cites this paper
• LINC01686 affects LPS‐induced cytokine expression via the miR‐18a‐5p/A20/STAT1 axis in THP‐1 cells

  2024cites this paper
• The Nuclear NF-κB Regulator IκBζ: Updates on Its Molecular Functions and Pathophysiological Roles

  2024cites this paper
• Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng.

  2024cites this paper
• Perturbomics of tumor-infiltrating NK cells

  2023cites this paper
• Regulation of lymphoid-myeloid lineage bias through regnase-1/3-mediated control of Nfkbiz

  2023cites this paper
• Regulation of IkappaB Protein Expression by Early Gestation in the Thymus of Ewes

  2023cites this paper
• The central inflammatory regulator IκBζ: induction, regulation and physiological functions

  2023cites this paper
• The macrophage infectivity potentiator of Trypanosoma cruzi induces innate IFN-γ and TNF-α production by human neonatal and adult blood cells through TLR2/1 and TLR4

  2023cites this paper
• Re-Exploring the Inflammation-Related Core Genes and Modules in Cerebral Ischemia

  2023cites this paper
• Spatially resolved deconvolution of the fibrotic niche in lung fibrosis

  2022cites this paper
• Vitamin A-treated natural killer cells reduce interferon-gamma production and support regulatory T cell differentiation

  2022cites this paper
• IκBζ controls IL-17-triggered gene expression program in intestinal epithelial cells that restricts colonization of SFB and prevents Th17-associated pathologies

  2022cites this paper
• Genetic variants in the NF-κB signaling pathway (NFKB1, NFKBIA, NFKBIZ) and risk of critical outcome among COVID-19 patients

  2022cites this paper
• Loss of IκBζ Drives Dentin Formation via Altered H3K4me3 Status

  2022cites this paper
• Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses

  2021cites this paper
• NF-κB and Its Regulators During Pregnancy

  2021cites this paper
• Aging-associated lncRNAs are evolutionarily conserved and participate in NFκB signaling

  2021cites this paper
• Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity.

  2020cites this paper
• Delayed IL-12 production by macrophages during Toxoplasma gondii infection is regulated by miR-187

  2020cites this paper
• In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated γδ T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells

  2020cites this paper
• Paradoxical psoriasis induced by TNF‐α blockade shows immunological features typical of the early phase of psoriasis development

  2019cites this paper
• IFNG-AS1 Enhances Interferon Gamma Production in Human Natural Killer Cells

  2019cites this paper
• IκBζ facilitates protective immunity against Salmonella infection via Th1 differentiation and IgG production

  2019cites this paper
• Identification of the E3 Ligase TRIM29 as a Critical Checkpoint Regulator of NK Cell Functions

  2019cites this paper
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  2019cites this paper
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  2018cites this paper
• NF-kappaB: Two Sides of the Same Coin

  2018cites this paper
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  2017cites this paper
• Toll-like receptor 9 stimulation can induce IκBζ expression and IgM secretion in chronic lymphocytic leukemia cells

  2017cites this paper
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  2017cites this paper
• Srebp-controlled glucose metabolism is essential for NK cell functional responses

  2017cites this paper
• Involvement of NF-κBIZ and related cytokines in age-associated renal fibrosis

  2017cites this paper
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  2016cites this paper
• Chromatin Remodeling and Transcriptional Control in Innate Immunity: Emergence of Akirin2 as a Novel Player

  2015cites this paper
• Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

  2015cites this paper
• Akirin2 is critical for inducing inflammatory genes by bridging IκB‐ζ and the SWI/SNF complex

  2014cites this paper
• Specific Dysregulation of IFNγ Production by Natural Killer Cells Confers Susceptibility to Viral Infection

  2014cites this paper
• Control of Toll-like Receptor-mediated T Cell-independent Type 1 Antibody Responses by the Inducible Nuclear Protein IκB-ζ

  2014cites this paper
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  2014cites this paper
• Transcriptional and post-transcriptional regulation of IκB-ζ upon engagement of the BCR, TLRs and FcγR.

  2013cites this paper
• Priming of NK Cell Anti-Viral Effector Mechanisms by Direct Recognition of Human Cytomegalovirus

  2013cites this paper
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  2013cites this paper
• Identification of interleukin‐1 receptor‐associated kinase 1 as a critical component that induces post‐transcriptional activation of IκB‐ζ

  2012cites this paper
• It takes two to tango: IκBs, the multifunctional partners of NF‐κB

  2012cites this paper
• Alternative nuclear functions for NF-κB family members.

  2011cites this paper
• NK cells: immune cross-talk and therapeutic implications.

  2011cites this paper
• IκBζ augments IL-12- and IL-18-mediated IFN-γ production in human NK cells.

  2011cites this paper