Swine interferon-induced transmembrane protein, sIFITM3, inhibits foot-and-mouth disease virus infection in vitro and in vivo

Highlights • Swine IFITM3 (sIFITM3) shares the conserved functional domains and amino acid residues with its human ortholog.• sIFITM3 restricts FMDV infection in BHK cells.• sIFITM3 disrupts FMDV viral attachment to the host cell surface.• sIFITM3 protects suckling mice from FMDV challenge.

• Publication year

  2014

• Venue

  Antiviral Research

• Publication date

  2014-06-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.antiviral.2014.06.008PMID 24973762PMCID 7113896
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cholesterol Dependence of Collagen and Echovirus 1 Trafficking along the Novel α2β1 Integrin Internalization Pathway

  2013cited by this paper
• The CD225 Domain of IFITM3 Is Required for both IFITM Protein Association and Inhibition of Influenza A Virus and Dengue Virus Replication

  2013influential reference
• Enhanced immunogenicity induced by an alphavirus replicon-based pseudotyped baculovirus vaccine against porcine reproductive and respiratory syndrome virus.

  2013cited by this paper
• Cholesterol Dependence of Collagen and Echovirus 1 Trafficking along the Novel alpha 2 beta 1 Integrin Internalization Pathway

  2013cited by this paper
• The Antiviral Effector IFITM3 Disrupts Intracellular Cholesterol Homeostasis to Block Viral Entry

  2013influential reference
• Interferon-inducible Transmembrane Protein 3 (IFITM3) Restricts Reovirus Cell Entry*

  2013cited by this paper
• Poly(I:C) combined with multi-epitope protein vaccine completely protects against virulent foot-and-mouth disease virus challenge in pigs.

  2013cited by this paper
• Enhanced inhibition of foot-and-mouth disease virus by combinations of porcine interferon-α and antiviral agents

  2012cited by this paper
• The N-Terminal Region of IFITM3 Modulates Its Antiviral Activity by Regulating IFITM3 Cellular Localization

  2012cited by this paper
• Novel Antiviral Therapeutics to Control Foot-and-Mouth Disease

  2012cited by this paper
• Innate immunity.

  2012cited by this paper
• IFITM1 is a tight junction protein that inhibits hepatitis C virus entry†, ‡

  2012cited by this paper
• Systematic identification of type I and type II interferon-induced antiviral factors

  2012cited by this paper
• IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry

  2011cited by this paper
• The Small Interferon-Induced Transmembrane Genes and Proteins

  2011influential reference
• Epidemic and Economic Impacts of Delayed Detection of Foot-And-Mouth Disease: A Case Study of a Simulated Outbreak in California

  2011cited by this paper
• Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus

  2011cited by this paper
• The Pfam protein families database

  2011cited by this paper
• Protective immunity elicited by a pseudotyped baculovirus-mediated bivalent H5N1 influenza vaccine.

  2011cited by this paper
• Development of vaccines toward the global control and eradication of foot-and-mouth disease

  2011cited by this paper
• Identification of Five Interferon-Induced Cellular Proteins That Inhibit West Nile Virus and Dengue Virus Infections

  2010cited by this paper
• Baculovirus treatment fully protects mice against a lethal challenge of FMDV.

  2010cited by this paper
• Interferon-Induced Cell Membrane Proteins, IFITM3 and Tetherin, Inhibit Vesicular Stomatitis Virus Infection via Distinct Mechanisms

  2010cited by this paper
• Ebola virus uses clathrin-mediated endocytosis as an entry pathway.

  2010cited by this paper
• The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.

  2009influential reference
• A Dominant-Negative Mutant of rab5 Inhibits Infection of Cells by Foot-and-Mouth Disease Virus: Implications for Virus Entry

  2009cited by this paper
• A pseudotype baculovirus-mediated vaccine confers protective immunity against lethal challenge with H5N1 avian influenza virus in mice and chickens.

  2009cited by this paper
• Development and validation of a duplex quantitative real-time RT-PCR assay for simultaneous detection and quantitation of foot-and-mouth disease viral positive-stranded RNAs and negative-stranded RNAs.

  2009cited by this paper
• Serological Survey for Foot-and-Mouth Disease Virus in Wildlife in Eastern Africa and Estimation of Test Parameters of a Nonstructural Protein Enzyme-Linked Immunosorbent Assay for Buffalo

  2008cited by this paper
• Interferon-inducible antiviral effectors

  2008cited by this paper
• Immune evasion during foot‐and‐mouth disease virus infection of swine

  2008cited by this paper
• The Pfam protein families database

  2007cited by this paper
• Vaccination against foot-and-mouth disease virus confers complete clinical protection in 7 days and partial protection in 4 days: Use in emergency outbreak response.

  2005cited by this paper
• Role of clathrin-mediated endocytosis during vesicular stomatitis virus entry into host cells.

  2005cited by this paper
• Endocytosis of influenza viruses.

  2004cited by this paper
• Foot-and-Mouth Disease

  2004cited by this paper
• Inhibition of proliferation by 1-8U in interferon-alpha-responsive and non-responsive cell lines.

  2003cited by this paper
• Inhibition of proliferation by 1-8U in interferon-α-responsive and non-responsive cell lines

  2003cited by this paper
• Novel Viral Disease Control Strategy: Adenovirus Expressing Alpha Interferon Rapidly Protects Swine from Foot-and-Mouth Disease

  2003cited by this paper
• Foot and mouth disease.

  2002influential reference
• Epidemiological characteristics and financial costs of the 1997 foot-and-mouth disease epidemic in Taiwan

  1999cited by this paper
• Innate immunity.

  1996cited by this paper
• Efficient selection for high-expression transfectants with a novel eukaryotic vector

  1991cited by this paper
• Efficient selection for high-expression transfectants with a novel eukaryotic vector.

  1991cited by this paper
• A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS

  1938cited by this paper

• Silencing RNA-Mediated Knockdown of IFITM3 Enhances Senecavirus A Replication

  2024influential citation
• Development and Application of a TaqMan RT-qPCR for the Detection of Foot-and-Mouth Disease Virus in Pigs

  2024cites this paper
• “Unveiling the genetic symphony: Diversity and expression of chicken IFITM genes in Aseel and Kadaknath breeds”

  2024cites this paper
• Analysis of Chicken IFITM3 Gene Expression and Its Effect on Avian Reovirus Replication

  2024cites this paper
• Chicken interferon-induced transmembrane protein 1 promotes replication of coronavirus infectious bronchitis virus in a cell-specific manner

  2022cites this paper
• Interferon–Inducible Transmembrane Protein 3 (IFITM3) Restricts Rotavirus Infection

  2022cites this paper
• Intrinsic antiviral immunity of barrier cells revealed by an iPSC-derived blood-brain barrier cellular model

  2022cites this paper
• Molecular characterization, expression and functional analysis of yak IFITM3 gene.

  2021cites this paper
• Regulatory Single Nucleotide Polymorphism of the Bovine IFITM3 Gene Induces Differential Transcriptional Capacities of Hanwoo and Holstein Cattle

  2021cites this paper
• DNA Methylation and SNP in IFITM3 are correlated with patients with hand, foot and mouth disease caused by enterovirus 71.

  2021cites this paper
• S-palmitoylation of swine interferon-inducible transmembrane protein is essential for its anti-JEV activity

  2020cites this paper
• A ferritin nanoparticle vaccine for foot-and-mouth disease virus elicited partial protection in mice.

  2020cites this paper
• Host antiviral protein IFITM2 restricts pseudorabies virus replication

  2020cites this paper
• Ethnic variation in risk genotypes based on single nucleotide polymorphisms (SNPs) of the interferon-inducible transmembrane 3 (IFITM3) gene, a susceptibility factor for pandemic 2009 H1N1 influenza A virus

  2020cites this paper
• Antiviral Role of IFITM Proteins in Classical Swine Fever Virus Infection

  2019cites this paper
• IFITM Genes, Variants, and Their Roles in the Control and Pathogenesis of Viral Infections

  2019cites this paper
• Construction, expression and antiviral activity analysis of recombinant adenovirus expressing human IFITM3 in vitro

  2019cites this paper
• The Host Restriction Factor Interferon-Inducible Transmembrane Protein 3 Inhibits Vaccinia Virus Infection

  2018cites this paper
• Combined administration of synthetic RNA and a conventional vaccine improves immune responses and protection against foot‐and‐mouth disease virus in swine

  2017cites this paper
• Characterization and anti-inflammation role of swine IFITM3 gene

  2017cites this paper
• 438. Human, Pig and Mouse IFITMs Partially Restrict Pseudotyped Lentiviral Vectors

  2016cites this paper
• Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism.

  2016cites this paper
• Esterase D enhances type I interferon signal transduction to suppress foot-and-mouth disease virus replication.

  2016cites this paper
• Immunogenicity of a recombinant Sendai virus expressing the capsid precursor polypeptide of foot-and-mouth disease virus.

  2016cites this paper
• Induction of systemic IFITM3 expression does not effectively control foot-and-mouth disease viral infection in transgenic pigs

  2016cites this paper
• Human, Pig, and Mouse Interferon-Induced Transmembrane Proteins Partially Restrict Pseudotyped Lentiviral Vectors

  2016cites this paper
• Global Foot-and-Mouth Disease Research Update and Gap Analysis: 5 - Biotherapeutics and Disinfectants.

  2016cites this paper
• Apigenin Restricts FMDV Infection and Inhibits Viral IRES Driven Translational Activity

  2015cites this paper