Positive regulation of osteogenesis by bile acid through FXR

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Bone and Mineral Research

• Publication date

  2013-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/jbmr.1961PMID 23609136
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Investigation of imatinib and other approved drugs as starting points for antidiabetic drug discovery with FXR modulating activity.

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  2011influential reference
• Activation of Liver X Receptor (LXR) Inhibits Receptor Activator of Nuclear Factor κB Ligand (RANKL)-induced Osteoclast Differentiation in an LXRβ-dependent Mechanism*

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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
• Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders.

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  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
• Lipids isolated from bone induce the migration of human breast cancer cells Published, JLR Papers in Press, January 26, 2006.

  2006cited by this paper
• International Union of Pharmacology. LXII. The NR1H and NR1I Receptors: Constitutive Androstane Receptor, Pregnene X Receptor, Farnesoid X Receptor α, Farnesoid X Receptor β, Liver X Receptor α, Liver X Receptor β, and Vitamin D Receptor

  2006cited by this paper
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  2006cited by this paper
• Farnesoid X receptor is essential for normal glucose homeostasis.

  2006cited by this paper
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  2006cited by this paper
• Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.

  2006cited by this paper
• Farnesoid X receptor: from structure to potential clinical applications.

  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2000influential reference
• The Farnesoid X-activated Receptor Mediates Bile Acid Activation of Phospholipid Transfer Protein Gene Expression*

  2000cited by this paper
• Identification of a nuclear receptor for bile acids.

  1999cited by this paper
• Bile acids: natural ligands for an orphan nuclear receptor.

  1999cited by this paper
• Embedding of Bone Samples in Methylmethacrylate: An Improved Method Suitable for Bone Histomorphometry, Histochemistry, and Immunohistochemistry

  1997cited by this paper
• Identification of a nuclear receptor that is activated by farnesol metabolites.

  1995cited by this paper
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  1987cited by this paper
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  1987cited by this paper

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