The anticancer effects and mechanisms of fucoxanthin combined with other drugs

No abstract is available for this paper.

• Publication year

  2019

• Venue

  Journal of Cancer Research and Clinical Oncology

• Publication date

  2019-01-09

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/s00432-019-02841-2PMID 30627824PMCID PMC11810181
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cytotoxic activity of fucoxanthin, alone and in combination with the cancer drugs imatinib and doxorubicin, in CML cell lines.

  2018cited by this paper
• Polymeric chitosan-glycolipid nanocarriers for an effective delivery of marine carotenoid fucoxanthin for induction of apoptosis in human colon cancer cells (Caco-2 cells).

  2018influential reference
• Low-dose doxorubicin with carotenoids selectively alters redox status and upregulates oxidative stress-mediated apoptosis in breast cancer cells.

  2018cited by this paper
• Fucoxanthin and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Synergistically Promotes Apoptosis of Human Cervical Cancer Cells by Targeting PI3K/Akt/NF-κB Signaling Pathway

  2018cited by this paper
• A marine bio-functional lipid, fucoxanthinol, attenuates human colorectal cancer stem-like cell tumorigenicity and sphere formation

  2017cited by this paper
• Antitumor Effects of Laminaria Extract Fucoxanthin on Lung Cancer

  2017cited by this paper
• Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways

  2017cited by this paper
• Sensitization of TRAIL-resistant cervical cancer cells through combination of TRAIL and fucoxanthin treatments.

  2017influential reference
• Fucoxanthin Activates Apoptosis via Inhibition of PI3K/Akt/mTOR Pathway and Suppresses Invasion and Migration by Restriction of p38-MMP-2/9 Pathway in Human Glioblastoma Cells

  2016cited by this paper
• Trailing TRAIL Resistance: Novel Targets for TRAIL Sensitization in Cancer Cells

  2015cited by this paper
• Anticancer effects of fucoxanthin and fucoxanthinol on colorectal cancer cell lines and colorectal cancer tissues.

  2015cited by this paper
• Fucoxanthin and Its Metabolite Fucoxanthinol in Cancer Prevention and Treatment

  2015cited by this paper
• Global cancer statistics, 2012

  2015cited by this paper
• Inhibitory effects of fucoxanthinol on the viability of human breast cancer cell lines MCF-7 and MDA-MB-231 are correlated with modulation of the NF-kappaB pathway

  2014cited by this paper
• Getting TRAIL back on track for cancer therapy

  2014cited by this paper
• The molecular mechanisms of TRAIL resistance in cancer cells: help in designing new drugs.

  2014cited by this paper
• Fucoxanthin Enhances Cisplatin-Induced Cytotoxicity via NFκB-Mediated Pathway and Downregulates DNA Repair Gene Expression in Human Hepatoma HepG2 Cells

  2013cited by this paper
• Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells.

  2013cited by this paper
• Leukaemias into the 21st century – part 2: the chronic leukaemias

  2013cited by this paper
• Epigenetic Regulation of SOX9 by the NF‐κB Signaling Pathway in Pancreatic Cancer Stem Cells

  2013cited by this paper
• Essential role of autophagy in fucoxanthin-induced cytotoxicity to human epithelial cervical cancer HeLa cells

  2013cited by this paper
• Oncogenicity of the developmental transcription factor Sox9.

  2012cited by this paper
• Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-A(y) mice.

  2012cited by this paper
• Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters.

  2012influential reference
• Transcriptional up-regulation of Sox9 by NF-κB in endometrial carcinoma cells, modulating cell proliferation through alteration in the p14(ARF)/p53/p21(WAF1) pathway.

  2012cited by this paper
• CaMKII γ, a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine.

  2012cited by this paper
• Fucoxanthin Attenuates Rifampin-Induced Cytochrome P450 3A4 (CYP3A4) and Multiple Drug Resistance 1 (MDR1) Gene Expression Through Pregnane X Receptor (PXR)-Mediated Pathways in Human Hepatoma HepG2 and Colon Adenocarcinoma LS174T Cells

  2012cited by this paper
• In Vivo Induction of Apoptosis by Fucoxanthin, a Marine Carotenoid, Associated with Down-Regulating STAT3/EGFR Signaling in Sarcoma 180 (S180) Xenografts-Bearing Mice

  2012cited by this paper
• [Single and 13-week oral toxicity study of fucoxanthin oil from microalgae in rats].

  2011cited by this paper
• Fucoxanthin and its deacetylated product, fucoxanthinol, induce apoptosis of primary effusion lymphomas.

  2011cited by this paper
• Global cancer statistics

  2011cited by this paper
• Doxorubicin pathways: pharmacodynamics and adverse effects

  2011cited by this paper
• Fucoxanthin inhibits the inflammatory response by suppressing the activation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages.

  2010cited by this paper
• Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway.

  2010cited by this paper
• Single and repeated oral dose toxicity study of fucoxanthin (FX), a marine carotenoid, in mice.

  2009cited by this paper
• Bioavailability and metabolism of fucoxanthin in rats: structural characterization of metabolites by LC-MS (APCI)

  2009cited by this paper
• Inhibition of proliferation of a hepatoma cell line by fucoxanthin in relation to cell cycle arrest and enhanced gap junctional intercellular communication.

  2009cited by this paper
• In vitro and in vivo evaluation of mutagenicity of fucoxanthin (FX) and its metabolite fucoxanthinol (FXOH).

  2009cited by this paper
• Implication of mitogen-activated protein kinase in the induction of G1 cell cycle arrest and gadd45 expression by the carotenoid fucoxanthin in human cancer cells.

  2009cited by this paper
• Novel orphan nuclear receptors-coregulator interactions controlling anti-cancer drug metabolism.

  2008cited by this paper
• Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D.

  2008cited by this paper
• Antiadult T‐cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol

  2008cited by this paper
• Evidence That Curcumin Suppresses the Growth of Malignant Gliomas in Vitro and in Vivo through Induction of Autophagy: Role of Akt and Extracellular Signal-Regulated Kinase Signaling Pathways

  2007cited by this paper
• Fucoxanthin, a natural carotenoid, induces G1 arrest and GADD45 gene expression in human cancer cells.

  2007cited by this paper
• Biochemical mechanisms of cisplatin cytotoxicity.

  2007cited by this paper
• Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma.

  2006cited by this paper
• Characterization of Apoptosis Induced by Fucoxanthin in Human Promyelocytic Leukemia Cells

  2005cited by this paper
• Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues.

  2005cited by this paper
• Cdc2 and Cdk2 play critical roles in low dose doxorubicin-induced cell death through mitotic catastrophe but not in high dose doxorubicin-induced apoptosis.

  2005cited by this paper
• Fucoxanthin induces cell cycle arrest at G0/G1 phase in human colon carcinoma cells through up-regulation of p21WAF1/Cip1.

  2005cited by this paper
• Cisplatin Damage: Are DNA Repair Proteins Saviors or Traitors to the Cell?

  2005cited by this paper
• Combined effects of As4S4 and imatinib on chronic myeloid leukemia cells and BCR-ABL oncoprotein.

  2004cited by this paper
• Mitochondrial DNA and its respiratory chain products are defective in doxorubicin nephrosis.

  2004cited by this paper
• Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells.

  2004cited by this paper
• Multidrug resistance in cancer: role of ATP–dependent transporters

  2002cited by this paper
• The nuclear receptor PXR: a master regulator of "homeland" defense.

  2002influential reference
• Characteristics of the peroxisome proliferator activated receptor γ (PPARγ) ligand induced apoptosis in colon cancer cells

  2002cited by this paper
• Brown algae fucoxanthin is hydrolyzed to fucoxanthinol during absorption by Caco-2 human intestinal cells and mice.

  2002cited by this paper
• Mechanisms of resistance to cisplatin.

  2001cited by this paper
• Down-regulation of bcr-abl and bcl-x(L) expression in a leukemia cell line and its doxorubicin-resistant variant by topoisomerase II inhibitors.

  2000cited by this paper
• Carotenoids and colon cancer.

  2000cited by this paper
• Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance.

  2000cited by this paper
• Review of the comparative pharmacology and clinical activity of cisplatin and carboplatin.

  1999cited by this paper
• Cancer prevention by carotenoids

  1999cited by this paper
• Activation of PPARγ leads to inhibition of anchorage-independent growth of human colorectal cancer cells

  1998cited by this paper
• Activation of PPARgamma leads to inhibition of anchorage-independent growth of human colorectal cancer cells.

  1998cited by this paper
• Beta‐carotene, carotenoids, and disease prevention in humans

  1996cited by this paper

• Transformative potential of plant-based nanoparticles in cancer diagnosis and treatment: bridging traditional medicine and modern therapy

  2025cites this paper
• Seaweed in the Diet as a Source of Bioactive Metabolites and a Potential Natural Immunity Booster: A Comprehensive Review

  2025cites this paper
• Systems Metabolic Engineering for Efficient Violaxanthin Production in Yeast.

  2024cites this paper
• Pregnane X Receptor Signaling Pathway and Vitamin K: Molecular Mechanisms and Clinical Relevance in Human Health

  2024cites this paper
• Alginate Profile, Antioxidant, and Antibacterial Activities of Brown Algae Sargassum cristaefolium from Pane Island, North Sumatera

  2023cites this paper
• Phytochemical compounds with promising biological activities from Ascophyllum nodosum extracts using microwave-assisted extraction.

  2023cites this paper
• Nanocomposite zinc oxide@ γ-linolenic acid-canagliflozin-fucoxanthin and/or γ-radiation perturbs key metabolic effectors and suppresses the proliferation of breast cancer cells in vitro

  2023cites this paper
• Anticancer Effects of Fucoxanthin through Cell Cycle Arrest, Apoptosis Induction, Angiogenesis Inhibition, and Autophagy Modulation

  2022cites this paper
• Carotenoids in Drug Discovery and Medicine: Pathways and Molecular Targets Implicated in Human Diseases

  2022cites this paper
• Production of Diadinoxanthin in an Intensive Culture of the Diatomaceous Alga Cylindrotheca closterium (Ehrenb.) Reimann et Lewin. and Its Proapoptotic Activity

  2022cites this paper
• Carotenoids from Marine Microalgae as Antimelanoma Agents

  2022cites this paper
• Fucoxanthin Suppresses Osteoclastogenesis via Modulation of MAP Kinase and Nrf2 Signaling

  2021cites this paper
• Innovation and Collaboration: Opportunities for the European Seaweed Sector in Global Value Chains

  2021influential citation
• Antiproliferative activity of marine brown algae-derived compounds: A review

  2021cites this paper
• Nutraceutical and Cosmeceutical Potential of Seaweed Derived Fucoxanthin

  2021cites this paper
• Bioprospecting of fucoxanthin from diatoms — Challenges and perspectives

  2021cites this paper
• Effects of Different Seaweed Bioactive Compounds on Neurodegenerative Disorders, Potential Uses on Insomnia: A Mini-review

  2021cites this paper
• Exploring the potential of photosynthetic induction factor for the commercial production of fucoxanthin in Phaeodactylum tricornutum

  2021cites this paper
• Seaweeds’ nutraceutical and biomedical potential in cancer therapy: a concise review

  2021cites this paper
• Fucoxanthin induced apoptotic cell death in oral squamous carcinoma (KB) cells

  2021cites this paper
• Fucoxanthin, A Xanthophyll from Macro- and Microalgae: Extraction Techniques, Bioactivities and Their Potential Application in Nutra- and Cosmeceutical Industries

  2021cites this paper
• Fucoxanthin and Phenolic Contents of Six Dictyotales From the Tunisian Coasts With an Emphasis for a Green Extraction Using a Supercritical CO2 Method

  2021cites this paper
• Fucoxanthin Holds Potential to Become a Drug Adjuvant in Breast Cancer Treatment: Evidence from 2D and 3D Cell Cultures

  2021cites this paper
• Cordycepin enhances the chemosensitivity of esophageal cancer cells to cisplatin by inducing the activation of AMPK and suppressing the AKT signaling pathway

  2020cites this paper
• Fucoxanthin modulates the development of 7, 12-dimethyl benz (a) anthracene-induced skin carcinogenesis in swiss albino mice in vivo

  2020cites this paper
• Heterologous production of the epoxycarotenoid violaxanthin in Saccharomyces cerevisiae.

  2020cites this paper
• Updated pigment composition of Tisochrysis lutea and purification of fucoxanthin using centrifugal partition chromatography coupled to flash chromatography for the chemosensitization of melanoma cells

  2020cites this paper
• Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials

  2019cites this paper
• Low-dose doxorubicin with carotenoids selectively alters redox status and upregulates oxidative stress-mediated apoptosis in breast cancer cells.

  2018cites this paper
• Identification of North Sea areas suitable for cultivating Saccharina latissima as an alternative source of protein

  year unknowncites this paper
• The Plymouth Student Scientist The Plymouth Student Scientist

  year unknowncites this paper