Tumor microenvironmental plasmacytoid dendritic cells contribute to breast cancer lymph node metastasis via CXCR4/SDF-1 axis

No abstract is available for this paper.

• Publication year

  2019

• Venue

  Breast Cancer Research and Treatment

• Publication date

  2019-01-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s10549-019-05129-8PMID 30632021
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The development and function of dendritic cell populations and their regulation by miRNAs

  2017cited by this paper
• Clinical implications of tumor necrosis factor receptor 2 in breast cancer.

  2017cited by this paper
• CXCR4 Ligands: The Next Big Hit?

  2017cited by this paper
• Prognostic impact of high levels of circulating plasmacytoid dendritic cells in breast cancer

  2016cited by this paper
• Immune microenvironment as a factor of breast cancer progression

  2015cited by this paper
• CXCR4 in breast cancer: oncogenic role and therapeutic targeting

  2015cited by this paper
• Positive lymph‐node breast cancer patients – activation of NF‐κB in tumor‐associated leukocytes stimulates cytokine secretion that promotes metastasis via C‐C chemokine receptor CCR7

  2015cited by this paper
• SDF-1/CXCR4 promotes epithelial-mesenchymal transition and progression of colorectal cancer by activation of the Wnt/β-catenin signaling pathway.

  2014cited by this paper
• The intricate role of CXCR4 in cancer.

  2014cited by this paper
• Tumor-Infiltrating Immune Cells Promoting Tumor Invasion and Metastasis: Existing Theories

  2013cited by this paper
• The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting.

  2013cited by this paper
• BDCA-2 (CD303): a highly specific marker for normal and neoplastic plasmacytoid dendritic cells.

  2013cited by this paper
• Dendritic Cells in the Cancer Microenvironment

  2012cited by this paper
• Quantitative comparison of immunohistochemical staining measured by digital image analysis versus pathologist visual scoring

  2012cited by this paper
• Standardizing immunophenotyping for the Human Immunology Project

  2012cited by this paper
• Depletion of Plasmacytoid Dendritic Cells Inhibits Tumor Growth and Prevents Bone Metastasis of Breast Cancer Cells

  2012cited by this paper
• CXCR4/SDF-1 axis is involved in lymph node metastasis of gastric carcinoma.

  2011cited by this paper
• Cathepsin b: a potential prognostic marker for inflammatory breast cancer

  2011cited by this paper
• CXCR4 and Axillary Lymph Nodes: Review of a Potential Biomarker for Breast Cancer Metastasis

  2011cited by this paper
• The dendritic cell-tumor cross-talk in cancer.

  2011cited by this paper
• Plasmacytoid dendritic cells: recent progress and open questions.

  2011cited by this paper
• Metastasis to sentinel lymph nodes in breast cancer is associated with maturation arrest of dendritic cells and poor co-localization of dendritic cells and CD8+ T cells

  2011cited by this paper
• NF-κB and cancer: a paradigm of Yin-Yang.

  2011cited by this paper
• Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells.

  2010cited by this paper
• Capturing and Characterizing Immune Cells from Breast Tumor Microenvironment: An Innovative Surgical Approach

  2010cited by this paper
• CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

  2010cited by this paper
• Molecular signatures of maturing dendritic cells: implications for testing the quality of dendritic cell therapies

  2010cited by this paper
• TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion

  2010cited by this paper
• Multiplexed immunophenotyping of human antigen-presenting cells in whole blood by polychromatic flow cytometry

  2010cited by this paper
• Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists.

  2010cited by this paper
• Quantifying Western blots: Pitfalls of densitometry

  2009cited by this paper
• Circulating tumor cells in pulmonary venous blood of primary lung cancer patients.

  2009cited by this paper
• Flow cytometric detection of circulating dendritic cells in healthy subjects.

  2009cited by this paper
• Migration of dendritic cell subsets and their precursors.

  2008cited by this paper
• Metastasis Suppressors and the Tumor Microenvironment

  2008cited by this paper
• Moving targets: cell migration inhibitors as new anti-inflammatory therapies

  2008cited by this paper
• Does the Presence of Circulating Tumor Cells in the Venous Drainage of Curative Colorectal Cancer Resections Determine Prognosis? A Meta-Analysis

  2008cited by this paper
• Accurate step wedge calibration for densitometry of electrophoresis gels

  2008cited by this paper
• Division of labor, plasticity, and crosstalk between dendritic cell subsets.

  2008cited by this paper
• Orchestrating the orchestrators: chemokines in control of T cell traffic

  2008cited by this paper
• Dendritic cells and cytokines in human inflammatory and autoimmune diseases.

  2008cited by this paper
• Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue.

  2007cited by this paper
• Butein, a Tetrahydroxychalcone, Inhibits Nuclear Factor (NF)-κB and NF-κB-regulated Gene Expression through Direct Inhibition of IκBα Kinase β on Cysteine 179 Residue*

  2007cited by this paper
• Breast cancer instructs dendritic cells to prime interleukin 13–secreting CD4+ T cells that facilitate tumor development

  2007cited by this paper
• Lower expression of CXCR4 in lymph node metastases than in primary breast cancers: potential regulation by ligand-dependent degradation and HIF-1alpha.

  2006cited by this paper
• TNF-α in promotion and progression of cancer

  2006cited by this paper
• TNF-alpha in promotion and progression of cancer.

  2006cited by this paper
• Silencing of CXCR4 blocks breast cancer metastasis.

  2005cited by this paper
• Plasmacytoid dendritic cells induce CD8+ regulatory T cells in human ovarian carcinoma.

  2005cited by this paper
• Stromal cell derived factor-1: its influence on invasiveness and migration of breast cancer cells in vitro, and its association with prognosis and survival in human breast cancer

  2005cited by this paper
• Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.

  2004cited by this paper
• Techniques of image analysis for quantitative immunohistochemistry.

  2004cited by this paper
• Dendritic Cell Infiltration and Prognosis of Early Stage Breast Cancer

  2004cited by this paper
• NF-κ B Promotes Breast Cancer Cell Migration and Metastasis by Inducing the Expression of the Chemokine Receptor CXCR4*

  2003cited by this paper
• Insights into the mechanisms of lymph node metastasis

  2003cited by this paper
• Cutting Edge: STAT6-Deficient Mice Have Enhanced Tumor Immunity to Primary and Metastatic Mammary Carcinoma1

  2000cited by this paper
• Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

  1998cited by this paper
• The process of metastasis

  1991cited by this paper
• The dendritic cell system and its role in immunogenicity.

  1991cited by this paper
• Axillary versus peripheral blood levels of sialic acid, ferritin, and CEA in patients with breast cancer

  1990cited by this paper
• The process of metastasis

  1985cited by this paper

• Immune Microenvironment in Breast Cancer Metastasis.

  2025cites this paper
• Suppressive effects on metastasis and tumor growth by the knockout of chemokine receptors in a canine cutaneous lymphoma model.

  2025cites this paper
• Multi-omics and functional characterization of the tumor-killing capacity of Imiquimod-activated plasmacytoid dendritic cells

  2025cites this paper
• Myeloid cells are involved in tumor immunity, metastasis and metabolism in tumor microenvironment

  2025cites this paper
• Single-cell transcriptomics of melanoma sentinel lymph nodes identifies immune cell signatures associated with metastasis

  2025cites this paper
• Tumor-infiltrating myeloid cells; mechanisms, functional significance, and targeting in cancer therapy

  2025cites this paper
• TNIP1 Impacts Prognosis by Modulating the Immune Microenvironment in BRCA

  2025cites this paper
• Malignancies and immunoglobulin G4‐related disease

  2025cites this paper
• Chemokines in the tumor microenvironment: implications for lung cancer and immunotherapy

  2024cites this paper
• High tumor glucocorticoid receptor expression in early-stage, triple-negative breast cancer is associated with increased T-regulatory cell infiltration

  2024cites this paper
• An insight into the role of innate immune cells in breast tumor microenvironment

  2024cites this paper
• Effector Functions of Dendritic Cells in Cancer: Role of Cytotoxicity and Growth Inhibition.

  2024cites this paper
• Plasmacytoid dendritic cells at the forefront of anti-cancer immunity: rewiring strategies for tumor microenvironment remodeling

  2024cites this paper
• The Multifaceted Functionality of Plasmacytoid Dendritic Cells in Gastrointestinal Cancers: A Potential Therapeutic Target?

  2024cites this paper
• Impact of the Cancer Cell Secretome in Driving Breast Cancer Progression

  2023cites this paper
• Role of indoleamine 2, 3-dioxygenase 1 in immunosuppression of breast cancer

  2023cites this paper
• Dendritic Cell Subpopulations Are Associated with Prognostic Characteristics of Breast Cancer after Neoadjuvant Chemotherapy—An Observational Study

  2023cites this paper
• Emerging roles of plasmacytoid dendritic cell crosstalk in tumor immunity

  2023cites this paper
• Competing endogenous RNA network characterization of lymph node metastases in Leuran gastric cancer subtypes

  2023cites this paper
• Lymph node metastasis and tumor-educated immune tolerance: Potential therapeutic targets against distant metastasis.

  2023cites this paper
• The Influence of the microbiome on the innate immune microenvironment of solid tumors

  2023cites this paper
• Beyond Immunosuppression: The Multifaceted Functions of Tumor-Promoting Myeloid Cells in Breast Cancers

  2022cites this paper
• Tumor‐associated human dendritic cell subsets: Phenotype, functional orientation, and clinical relevance

  2022cites this paper
• Epigenetic Regulation of CXCR4 Signaling in Cancer Pathogenesis and Progression.

  2022cites this paper
• Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer

  2022cites this paper
• Increased tumor-infiltrating plasmacytoid dendritic cells promote cancer cell proliferation and invasion via TNF-α/NF-κB/CXCR-4 pathway in oral squamous cell carcinoma

  2021cites this paper
• A Comprehensive Investigation to Reveal the Relationship Between Plasmacytoid Dendritic Cells and Breast Cancer by Multiomics Data Analysis

  2021cites this paper
• Hypoxia promotes the tolerogenic phenotype of plasmacytoid dendritic cells in head and neck squamous cell carcinoma

  2021cites this paper
• The Comprehensive Analysis of Competitive Endogenous RNA Networks and Tumor-Infiltrating Immune Cells in Gastric Cancer With Lymph Node Metastasis

  2021cites this paper
• Key promoters of tumor hallmarks

  2021cites this paper
• The Role of Plasmacytoid Dendritic Cells in Cancers

  2021cites this paper
• CD303 (BDCA-2) – a potential novel target for therapy in hematologic malignancies

  2021cites this paper
• Crosstalk between Tumor-Infiltrating Immune Cells and Cancer-Associated Fibroblasts in Tumor Growth and Immunosuppression of Breast Cancer

  2021influential citation
• The differentiation of new human CD303+ Plasmacytoid dendritic cell subpopulations expressing CD205 and/or CD103 regulated by Non-Small-Cell lung cancer cells.

  2021cites this paper
• Dendritic Cells Are Associated with Prognosis and Survival in Breast Cancer

  2021cites this paper
• Increased Tumor-In ltrating Plasmacytoid Dendritic Cells Promote Cancer Cell Proliferation and Metastasis via TNF- α/NF-κB/CXCR-4 Pathway in Oral Squamous Cell Carcinoma

  2020cites this paper
• Human Plasmacytoid Dendritic Cells and Cutaneous Melanoma

  2020cites this paper
• Characterization of the Prognostic Values of the CXCR1-7 in Clear Cell Renal Cell Carcinoma (ccRCC) Microenvironment

  2020cites this paper
• At the Bench: Pre‐clinical evidence for multiple functions of CXCR4 in cancer

  2020cites this paper
• The Signaling Duo CXCL12 and CXCR4: Chemokine Fuel for Breast Cancer Tumorigenesis

  2020cites this paper
• Studying Lymphatic Metastasis in Breast Cancer: Current Models, Strategies, and Clinical Perspectives

  2020cites this paper
• CXC Chemokine Receptors in the Tumor Microenvironment and an Update of Antagonist Development.

  2020cites this paper
• Functional Role of Dendritic Cell Subsets in Cancer Progression and Clinical Implications

  2020cites this paper
• The N‐terminal polypeptide derived from vMIP‐II exerts its antitumor activity in human breast cancer through CXCR4/miR‐7‐5p/Skp2 pathway

  2020cites this paper
• CXCL12/CXCR4 axis in the microenvironment of solid tumors: A critical mediator of metastasis.

  2020cites this paper
• Immune response profile of primary tumour, sentinel and non-sentinel axillary lymph nodes related to metastasis in breast cancer: an immunohistochemical point of view

  2019cites this paper
• Effect of CXCL12/CXCR4 on migration of decidua‐derived mesenchymal stem cells from pregnancies with preeclampsia

  2019cites this paper
• Mechanisms and Functional Significance of Human Tumor-infiltrating Myeloid Cells

  2019cites this paper
• Targeting CXCR4 potentiates anti-PD-1 efficacy modifying the tumor microenvironment and inhibiting neoplastic PD-1

  2019cites this paper