THE MECHANISM OF CORTISOL ACTION IN CULTURED RAT HEART CELLS

Heart cells growing as monolayer cells in tissue culture have the ability to beat (1) . After several day in culture these same cells cease functioning and lose the morphology characteristic of beating cells . This process by which heart cells lose their ability to beat in culture has been described as dedifferentiation (2) . While studying the effect of steroids on beating, McCarl et al . (3) demonstrated that cortisol not only will enhance the per cent of beating in heart cell cultures, but also will re-initiate beating in those cells which have ceased to function . Thus, cortisol restores and maintains the functionally differentiated state of the heart cell in culture . Since cortisol is instrumental in maintaining the differentiated state of heart cells in culture, studies were performed to determine how the hormone controls the beating phenomenon in heart cells . This report is concerned with the effects of cortisol on RNA and protein synthesis in heart cells and their relationship to beating.

• Publication year

  1971

• Venue

  Journal of Cell Biology

• Publication date

  1971-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/JCB.49.1.205PMID 5555574PMCID 2108193
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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