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Resveratrol pretreatment reduces circulating inflammatory interleukins in CCl4-induced hepatotoxicity rats

Y. Kandil,A. Maraqa,Ghaleb A. Oriquat,Z. Shraideh

Published 2017 in Bulletin of Faculty of Pharmacy, Cairo University

ABSTRACT

Abstract Liver diseases represent one of major health burdens worldwide, both oxidative stress and inflammation play crucial roles in the development of liver diseases. Resveratrol (RSV), a naturally occurring compound, has recently been shown to exert anti-oxidative and anti-inflammatory actions. This work aimed to investigate the prophylactic effect of RSV against CCl 4 -induced hepatotoxicity in experimental rats in terms of inflammatory interleukins and histopathological changes. Twenty-four adult male rats were divided into three equal groups: group A: Negative control, received oral vehicle, group B: Positive control, received oral vehicle for 6 days and on 6 th day injected with single dose of CCl 4 , and group C: RSV-treated group, received oral RSV (25 mg/kg/day) for 6 days and on 6 th day injected with single dose of CCl 4 . 24 h after induction of hepatotoxicity by CCl 4 , all rats were sacrificed; liver was excised for histopathological studies and blood samples were collected. ALT, AST, ALP, total bilirubin, IL-1β, IL-6, and IL-10 were determined in plasma while total GSH, MDA, GPx, and SOD were assayed in liver homogenate. Plasma levels of ALT, AST, ALP, total-bilirubin, IL-1β, and IL-6 were significantly increased 24 h after induction of hepatotoxicity by CCl 4 while IL-10 decreased. Pretreatment of rats with RSV prevented these changes. The histopathological changes were less obvious in livers of RSV-treated rats in comparative to positive control. In conclusion, RSV has a prophylactic effect against hepatotoxicity induced by CCl 4 through decreasing the inflammatory interleukins level.

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