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Early Detection Research Network: Accomplishments and Outlook.

S. Srivastava,Sharmistha Ghosh

Published 2018 in The Journal of Applied Laboratory Medicine

ABSTRACT

In 2000, the National Cancer Institute established the Early Detection Research Network (EDRN) to discover, develop, and validate biomarkers to detect cancers early when they are most treatable. The EDRN′s mission recently expanded to include finding and validating biomarkers that can determine which neoplasias are likely to progress to aggressive disease and to develop and validate imaging methods to better detect and characterize early-stage cancers. EDRN investigators have made significant progress toward achieving these goals, including participation in the discovery and/or validation of 6 diagnostic tests that have been approved by the Food and Drug Administration and 12 tests that are in use in CLIA laboratories. This progress is because of the quality research conducted by the EDRN investigators, the integrated structure of the EDRN that fosters a collaborative teamwork approach, and the ability of the EDRN to collaboratively validate biomarkers and imaging methods developed by non-EDRN investigators. The network includes >30 institutions, >150 investigators, and >200 associate members (i.e., non-EDRN investigators). The development of new biomarkers for early detection of cancer is a lengthy process that begins with the discovery of promising candidate biomarkers, rigorous validation, and implementation in the clinic. Biomarkers that successfully meet clinical significance thresholds can be practice changing, and the ultimate level of success is to …

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