Diagnostic ability of macular ganglion cell asymmetry in Preperimetric Glaucoma

BackgroundTo evaluate the diagnostic ability of macular ganglion cell asymmetry to diagnose preperimetric glaucoma (PPG), using Cirrus spectral domain optical coherence tomography (OCT).MethodsThis prospective study included 67 eyes of 67 patients with PPG and 67 eyes of 67 age- and refractive error-matched controls. We measured circumpapillary RNFL (cpRNFL) thickness, macular ganglion cell-inner plexiform layer (GCIPL) thickness and optic nerve head (ONH) parameters using OCT. Macular ganglion cell asymmetries were expressed as absolute difference and ratios between inferior hemisphere and superior hemisphere, inferotemporal (IT) and superotemporal (ST), IT and superonasal (SN), IT and inferonasal (IN), ST and IN as well as temporal and nasal. An asymmetry index was assigned by taking the absolute value of log10 of the ratio. The area under the receiver operating characteristics curve (AUROC), partial AUROC (pAUROC) ≥ specificities 90 and 95%, cutoff values and sensitivities at specificities 90 and 95% was analyzed.ResultsParameters with largest AUROCs were IT GCIPL thickness (0.784), average RNFL thickness (0.767), and average C/D (0.746). For macular asymmetry parameters, log IT/SN index had the largest AUROC (0.734), followed by log IT/IN index (0.725), and absolute difference of IT−SN GCIPL thickness (0.715). Performance was comparable between the best measures of asymmetry analysis (log IT/SN index) and those of cpRNFL, GCIPL, and ONH parameters (all P > 0.05). The IT/SN asymmetry index not only had the largest pAUROC based on the pAUROCs ≥90 and 95% specificity (0.044 and 0.019) but also had the highest diagnostic sensitivity at 90 and 95% specificities (52.2 and 46.3%).ConclusionsGCIPL asymmetry measurements have diagnostic ability comparable to cpRNFL, GCIPL, and ONH analysis for PPG. The best macular ganglion cell asymmetry parameter was IT/SN asymmetry index, which could be a new parameter to detect early structural changes in PPG.

• Publication year

  2019

• Venue

  BMC Ophthalmology

• Publication date

  2019-01-08

• Fields of study

  Medicine

• Identifiers
  DOI 10.1186/s12886-018-1019-4PMID 30621639PMCID 6325869
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vertical Macular Asymmetry Measures Derived From SD-OCT for Detection of Early Glaucoma

  2017cited by this paper
• Glaucoma Detection Ability of Macular Ganglion Cell-Inner Plexiform Layer Thickness in Myopic Preperimetric Glaucoma.

  2015cited by this paper
• Automated Detection of Hemifield Difference across Horizontal Raphe on Ganglion Cell--Inner Plexiform Layer Thickness Map.

  2015cited by this paper
• Validity of the temporal‐to‐nasal macular ganglion cell–inner plexiform layer thickness ratio as a diagnostic parameter in early glaucoma

  2015cited by this paper
• Diagnostic ability of macular ganglion cell asymmetry for glaucoma

  2015cited by this paper
• Diagnostic performance of optical coherence tomography ganglion cell--inner plexiform layer thickness measurements in early glaucoma.

  2014cited by this paper
• A formula for human retinal ganglion cell receptive field density as a function of visual field location.

  2014cited by this paper
• Macular ganglion cell analysis for early detection of glaucoma.

  2014cited by this paper
• Diagnostic Validity of Macular Ganglion Cell-Inner Plexiform Layer Thickness Deviation Map Algorithm Using Cirrus HD-OCT in Preperimetric and Early Glaucoma

  2014cited by this paper
• Asymmetry analysis of macular inner retinal layers for glaucoma diagnosis.

  2014cited by this paper
• Topographic profiles of retinal nerve fiber layer defects affect the diagnostic performance of macular scans in preperimetric glaucoma.

  2014cited by this paper
• Ganglion cell-inner plexiform layer thickness of high definition optical coherence tomography in perimetric and preperimetric glaucoma.

  2014cited by this paper
• Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric glaucoma.

  2013cited by this paper
• Glaucomatous damage of the macula.

  2013cited by this paper
• Diagnostic precision of retinal nerve fiber layer and macular thickness asymmetry parameters for identifying early primary open-angle glaucoma.

  2013cited by this paper
• Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: interpreting the RNFL maps in healthy myopic eyes.

  2012cited by this paper
• Detection of localized retinal nerve fiber layer defects with posterior pole asymmetry analysis of spectral domain optical coherence tomography.

  2012cited by this paper
• The Nature of Macular Damage in Glaucoma as Revealed by Averaging Optical Coherence Tomography Data.

  2012cited by this paper
• Asymmetry in hemifield macular thickness as an early indicator of glaucomatous change.

  2012cited by this paper
• Glaucoma diagnostic accuracy of ganglion cell-inner plexiform layer thickness: comparison with nerve fiber layer and optic nerve head.

  2012cited by this paper
• Novel software strategy for glaucoma diagnosis: asymmetry analysis of retinal thickness.

  2011cited by this paper
• Three-dimensional imaging of macular inner structures in glaucoma by using spectral-domain optical coherence tomography.

  2011cited by this paper
• Wake transition of a rolling sphere

  2011cited by this paper
• Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography.

  2009cited by this paper
• Neural losses correlated with visual losses in clinical perimetry.

  2004cited by this paper
• Ganglion cell losses underlying visual field defects from experimental glaucoma.

  1999cited by this paper
• Topography of ganglion cells in human retina

  1990cited by this paper
• Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma.

  1989cited by this paper
• Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.

  1988cited by this paper
• Optic nerve damage in human glaucoma. III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischemic neuropathy, papilledema, and toxic neuropathy.

  1982cited by this paper

• Evaluation of the Diagnostic Capability of Spectralis SD-OCT 8 × 8 Posterior Pole Software with the Grid Tilted at 7 Degrees and Horizontalized in Glaucoma

  2024cites this paper
• Diagnostic ability of macular nerve fiber layer thickness measured by swept-source optical coherence tomography in preperimetric glaucoma

  2024cites this paper
• Perimetric visual field testing reveals deficits in contrast sensitivity in workers exposed to occupational levels of pesticides

  2024cites this paper
• Differentiating glaucoma from chiasmal compression using optical coherence tomography: the macular naso-temporal ratio

  2023cites this paper
• Reference Database of Inner Retinal Layer Thickness and Thickness Asymmetry in Healthy Thai Adults as Measured by the Spectralis Spectral-Domain Optical Coherence Tomography

  2022cites this paper
• Discriminating capabilities of neural and vascular parameters of optical coherent tomography in glaucoma

  2022cites this paper
• Facilitating glaucoma diagnosis with intereye neuroretinal rim asymmetry analysis using spectral-domain optical coherence tomography.

  2022cites this paper
• Structural and functional differentiation between compressive and glaucomatous optic neuropathy

  2022cites this paper
• DISCRIMINATION OF EYES WITH PRIMARY OPEN-ANGLE GLAUCOMA FROM NORMAL USING MACULAR GC-IPL THICKNESS

  2022cites this paper
• Macular ganglion cell-inner plexiform layer defect patterns in multiple sclerosis patients without optic neuritis: A Spectral-Domain-Optical Coherence Tomography Cross-Sectional, Case-Control, Pilot Study

  2022cites this paper
• Vessel Density in the Macular and Peripapillary Areas in Preperimetric Glaucoma to Various Stages of Primary Open-Angle Glaucoma in Taiwan

  2021cites this paper
• Circumpapillary optical coherence tomography angiography differences in perimetrically affected and unaffected hemispheres in primary open-angle glaucoma and the preperimetric fellow eye

  2021cites this paper
• Focal alteration of the intraretinal layers in neurodegenerative disorders.

  2020cites this paper
• Macular vessel density versus ganglion cell complex thickness for detection of early primary open-angle glaucoma

  2020cites this paper
• Relationship between optic nerve head topography and nerve fiber layer thickness with central corneal thickness in patients with primary open-angle glaucoma

  2020cites this paper
• OPTH_A_256755 1591..1599

  2020cites this paper
• Optic Disc and Macular Vessel Density Measured by Optical Coherence Tomography Angiography in Open-Angle and Angle-Closure Glaucoma

  2020cites this paper
• Original Relationship between optic nerve head topography and nerve fiber layer thickness with central corneal thickness in patients with primary open-angle glaucoma

  2020cites this paper
• Macular Imaging with Optical Coherence Tomography in Glaucoma.

  2020cites this paper
• Profiles of Ganglion Cell-Inner Plexiform Layer Thickness in a Multi-Ethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study.

  2020cites this paper
• Does Retinal Ganglion Cell Loss Precede Visual Field Loss in Glaucoma?

  2019cites this paper
• Individual Macular Layer Evaluation with Spectral Domain Optical Coherence Tomography in Normal and Glaucomatous Eyes

  2019cites this paper
• Focal Thickness Reduction of the Ganglion Cell-Inner Plexiform Layer Best Discriminates Prior Optic Neuritis in Patients With Multiple Sclerosis

  2019cites this paper