Clinical analysis of neck node metastasis in oral cavity cancer

Objectives The purpose of this study was to evaluate the neck node metastasis pattern and related clinical factors in oral cavity cancer patients. Materials and Methods In total, 76 patients (47 males, 29 females) with oral squamous cell carcinoma (OSCC) who had no previous malignancies and were not undergoing neoadjuvant concomitant chemoradiotherapy or radiotherapy were selected for analysis. Results Occult metastases were found in 8 of 52 patients with clinically negative nodes (cN0, 15.4%). Neck node metastases were found in 17 patients (22.4%). There was a statistically significant relationship between neck node metastasis and T stage (P=0.014) and between neck node metastasis and distant metastasis (Fisher's exact test, P=0.019). Conclusion Neck node metastasis was significantly related to tumor size and distant metastasis during follow-up.

• Publication year

  2018

• Venue

  Journal of the Korean Association of Oral and Maxillofacial Surgeons

• Publication date

  2018-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.5125/jkaoms.2018.44.6.282PMID 30637242PMCID 6327011
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Is Superselective Neck Dissection Safer Than Supraomohyoid Neck Dissection for Oral Carcinoma Patients With N0 Neck in Terms of Shoulder Morbidity and Recurrence Rate?

  2017cited by this paper
• Neck failure after elective neck dissection in patients with oral squamous cell carcinoma.

  2017influential reference
• [Oral cancer -diagnosis and therapy-.]

  2017cited by this paper
• The role of elective neck dissection in early stage buccal cancer

  2015cited by this paper
• Lymph node ratio influence on risk of head and neck cancer locoregional recurrence after initial surgical resection: Implications for adjuvant therapy

  2015cited by this paper
• Transfer of anterolateral thigh flaps in elderly oral cancer patients: complications in oral and maxillofacial reconstruction.

  2015cited by this paper
• The Harmonic Scalpel versus Conventional Hemostasis for Neck Dissection: A Meta-Analysis of the Randomized Controlled Trials

  2015cited by this paper
• Is Lymph-node Ratio a Superior Predictor than Lymph Node Status for Recurrence-free and Overall Survival in Patients with Head and Neck Squamous Cell Carcinoma?

  2014cited by this paper
• Anterolateral thigh myocutaneous flaps as the preferred flaps for reconstruction of oral and maxillofacial defects.

  2014cited by this paper
• Supraomohyoid neck dissection and modified radical neck dissection for clinically node-negative oral squamous cell carcinoma: a prospective study of prognosis, complications and quality of life.

  2014cited by this paper
• Prognostic biological features in neck dissection specimens

  2013cited by this paper
• Shoulder function after selective and superselective neck dissections: clinical and functional outcomes

  2012cited by this paper
• Global cancer statistics

  2011cited by this paper
• A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck.

  2011cited by this paper
• Clinicopathological parameters, recurrence, locoregional and distant metastasis in 115 T1-T2 oral squamous cell carcinoma patients

  2010cited by this paper
• The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM

  2010cited by this paper
• Predictive factors of isolated distant metastasis after primary definitive surgery without systemic treatment for head and neck squamous cell carcinoma.

  2010cited by this paper
• Lymph node density is a significant predictor of outcome in patients with oral cancer

  2009cited by this paper
• Prospective randomized study of selective neck dissection versus observation for N0 neck of early tongue carcinoma

  2009cited by this paper
• Decision analysis and treatment threshold in a management for the N0 neck of the oral cavity carcinoma.

  2009influential reference
• Analysis of risk factors for distant metastases in squamous cell carcinoma of the oral cavity

  2007cited by this paper
• Elective neck dissection in early‐stage oral squamous cell carcinoma—does it influence recurrence and survival?

  2007cited by this paper
• Risk factors for distant metastases in head and neck squamous cell carcinoma.

  2006cited by this paper
• Elective neck treatment versus observation in patients with T1/T2 N0 squamous cell carcinoma of oral tongue.

  2006cited by this paper
• Relevance of Skip Metastases for Squamous Cell Carcinoma of the Oral Tongue and the Floor of the Mouth

  2006cited by this paper
• Elective Neck Dissection and Survival in Patients With Squamous Cell Carcinoma of the Oral Cavity and Oropharynx

  2004cited by this paper
• Prognostic factors of clinically stage I and II oral tongue carcinoma—A comparative study of stage, thickness, shape, growth pattern, invasive front malignancy grading, martinez‐gimeno score, and pathologic features

  2002cited by this paper
• Diet and cancer of oral cavity and pharynx: a case-control study in São Paulo, Brazil.

  2002cited by this paper
• Results of salvage treatment of the neck in patients with oral cancer.

  2002cited by this paper
• Elective Neck Dissection versus Observation in Stage I Squamous Cell Carcinomas of the Tongue and Floor of the Mouth

  2001cited by this paper
• Distant metastases in head and neck cancer patients who achieved loco‐regional control

  2000cited by this paper
• Improved survival for patients with clinically T1/T2, N0 tongue tumors undergoing a prophylactic neck dissection

  1999cited by this paper
• Impact of Neck Dissection on Quality of Life

  1999cited by this paper
• Can we detect or predict the presence of occult nodal metastases in patients with squamous carcinoma of the oral tongue?

  1998cited by this paper
• Frequency and therapeutic implications of "skip metastases" in the neck from squamous carcinoma of the oral tongue.

  1997cited by this paper
• Frequency and therapeutic implications of “skip metastases” in the neck from squamous carcinoma of the oral tongue

  1997cited by this paper
• Elective neck dissection versus observation in the treatment of early oral tongue carcinoma

  1997cited by this paper
• Supraomohyoid neck dissection in the treatment of T1/T2 squamous cell carcinoma of oral cavity.

  1994cited by this paper
• Lymph node prognostic factors in head and neck squamous cell carcinomas.

  1994cited by this paper
• Use of decision analysis in planning a management strategy for the stage N0 neck.

  1994cited by this paper
• Treatment of stage I and II oral tongue cancer

  1993cited by this paper
• Prognostic value of various molecular and cellular features in oral squamous cell carcinomas: a review.

  1991cited by this paper
• Elective versus therapeutic neck dissection in early carcinoma of the oral tongue.

  1989cited by this paper
• Cancer statistics

  1989cited by this paper
• Cancer statistics, 1986

  1986cited by this paper
• Elective versus therapeutic radical neck dissection in epidermoid carcinoma of the oral. Cavity results of a randomized clinical trial

  1980cited by this paper
• Anatomical site and size of 222 early asymptomatic oral squamous cell carcinomas. A continuing prospective study of oral cancer. II

  1976cited by this paper

• Epithelial-Mesenchymal Transition, Immune Response, and Extracellular Matrix Remodelling in Oral Cancer.

  2026cites this paper
• Salivary MicroRNAs as Innovative Biomarkers for Diagnosis and Prediction of the Oral Potentially Malignant Disorders Transition Towards Oral Cancer: A Systematic Review

  2025cites this paper
• Distant metastasis of oral squamous cell carcinoma: immune escape mechanism and new perspectives on treatment

  2025cites this paper
• Sentinel Lymph Node Biopsy Versus Elective Neck Dissection in Carcinoma of the Tongue and Floor of the Mouth

  2025cites this paper
• Analysis of Clinicopathological Profile of Patients with Metastatic Oral Squamous Cell Carcinoma: An Observational Study

  2025cites this paper
• Chlorogenic acid-rich fraction from Coffea canaphora attenuates periodontal bacteria growth and lipopolysaccharide-stimulated oral squamous cell carcinoma progression

  2025cites this paper
• Neck dissection in pT1 maxillary squamous cell carcinoma: Necessity or overtreatment?

  2025cites this paper
• Low expression of interleukin-1 receptor antagonist correlates with poor prognosis via promoting proliferation and migration and inhibiting apoptosis in oral squamous cell carcinoma.

  2024cites this paper
• Hatti’s Plexus, An Added Landmark in Level IB Lymphnode Dissection of Neck

  2024cites this paper
• Assessment of Pattern of Cervical Lymph Node Metastasis in Squamous Cell Carcinoma of Oral Cavity

  2024influential citation
• PREVALENCE OF OCCULT CERVICAL LYMPH NODES METASTASIS IN CN0 IN ORAL SQUAMOUS CELL CARCINOMA (OSCC).

  2024cites this paper
• Oncologic Outcomes of Salvage Surgery in Recurrent Oral Tongue Squamous Cell Carcinoma

  2024cites this paper
• Prognostic Significance of Lymph Node Ratio in Predicting the Outcome of Oral Squamous Cell Carcinoma – A Retrospective Study

  2024cites this paper
• Identification of Neck Lymph Node Metastasis-Specific microRNA—Implication for Use in Monitoring or Prediction of Neck Lymph Node Metastasis

  2023cites this paper
• STUDY TO EVALUATE CLINICOPATHOLOGICALASSOCIATION BETWEEN DEPTH OF INVASION AND NECK NODE METASTASIS IN ORAL CAVITY CARCINOMA

  2023cites this paper
• Diagnostic Accuracy of Up-Front PET/CT and MRI for Detecting Cervical Lymph Node Metastases in T1–T2 Oral Cavity Cancer—A Prospective Cohort Study

  2023cites this paper
• Prevalence of Skip Metastases to Cervical Lymph-Nodes in Oral cavity Cancer in Eastern India-an observational study

  2022cites this paper
• Human telomerase reverse transcriptase protein expression is associated with survival in patients with oral squamous cell carcinoma.

  2022cites this paper
• ENO1 Binds to ApoC3 and Impairs the Proliferation of T Cells via IL-8/STAT3 Pathway in OSCC

  2022cites this paper
• Case Serie of Hybrid Brachytherapy followed by Intensity Modulated Radiation Therapy (HyBIRT) Technique for the De nitive Management of Tongue Squamous Cell Carcinoma (TSCC)

  2022cites this paper
• Aloin promotes oral squamous cell carcinoma cell apoptosis and autophagy through Akt/mTOR pathway

  2022cites this paper
• Patterns of Neck Nodal Metastasis from Oral Cavity Carcinoma

  2022cites this paper
• Suppurative mastoid lymphadenitis mimicking mastoiditis: a case report

  2021cites this paper
• CMAR_A_319048 5725..5737

  2021cites this paper
• Management of Oral Cancers

  2021cites this paper
• Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma

  2021cites this paper
• Oral squamous cell carcinoma: metastasis, potentially associated malignant disorders, etiology and recent advancements in diagnosis

  2020cites this paper
• Bioinformatics analysis of aberrantly expressed exosomal lncRNAs in oral squamous cell carcinoma (CAL-27 vs. oral epithelial) cells

  2020cites this paper
• IN SILICO GENE EXPRESSION ANALYSIS OF CRUCIAL CELL CYCLE CONTROL GENE CDKN2A AND CDKN2B IN HEAD AND NECK SQUAMOUS CELL CARCINOMA

  2020cites this paper
• Correlation of Site of Occurrence of Oral Squamous Cell Carcinoma and Level of Lymph Node Metastasis

  2020cites this paper
• Oral Cancer Senario in Multiple Centers of Dhaka, Bangladesh

  2020influential citation
• Radiotherapy in Management of Oral Cancer

  2020cites this paper
• Case Serie of Hybrid Brachytherapy followed by Intensity Modulated Radiation Therapy (HyBIRT) Technique for the De�nitive Management of Tongue Squamous Cell Carcinoma (TSCC)

  year unknowncites this paper