Associations of Plasma Phospholipid and Dietary Alpha Linolenic Acid With Incident Atrial Fibrillation in Older Adults: The Cardiovascular Health Study

Background Few studies have examined the relationship of α‐linolenic acid (ALA 18:3n‐3), an intermediate‐chain essential n‐3 polyunsaturated fatty acid derived from plants and vegetable oils, with incident atrial fibrillation (AF). Methods and Results The study population included participants from the Cardiovascular Health Study, a community‐based longitudinal cohort of adults aged 65 or older, free of prevalent coronary heart disease and atrial fibrillation. We assessed the associations of plasma phospholipid and dietary ALA with incident AF using Cox regression. The biomarker analysis comprised a total of 2899 participants, and the dietary analysis comprised 4337 participants. We found no association of plasma phospholipid ALA and incident AF. Comparing each of the second, third, and fourth quartiles to the lowest quartile, the hazard ratios for AF were 1.11 (95% CI, 0.90 to 1.37), 1.09 (95% CI, 0.88 to 1.35), and 0.92 (95% CI, 0.74 to 1.15), after adjustment for age, sex, race, clinic, education, smoking, alcohol, body mass index, waist circumference, diabetes, heart failure, stroke, treated hypertension, and physical activity (P trend=0.48). When dietary ALA was considered the exposure of interest, results were similar. Conclusions Results from this prospective cohort study of older adults indicate no association of plasma phospholipid or dietary ALA and incident AF.

• Publication year

  2013

• Venue

  Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease

• Publication date

  2013-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/JAHA.112.003814PMID 23525429PMCID 3603242
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Plasma and dietary omega-3 fatty acids, fish intake, and heart failure risk in the Physicians' Health Study.

  2012cited by this paper
• Association of Plasma Phospholipid Long-Chain Omega-3 Fatty Acids With Incident Atrial Fibrillation in Older Adults: The Cardiovascular Health Study

  2012cited by this paper
• Plasma omega-3 fatty acids and incident diabetes in older adults.

  2011cited by this paper
• Dietary factors and incident atrial fibrillation: the Framingham Heart Study.

  2011cited by this paper
• Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium

  2011cited by this paper
• [The Rotterdam study].

  2011cited by this paper
• Dietary fish intake and incident atrial fibrillation (from the Women's Health Initiative).

  2010cited by this paper
• Serum Long-Chain n-3 Polyunsaturated Fatty Acids and Risk of Hospital Diagnosis of Atrial Fibrillation in Men

  2009cited by this paper
• Increasing prevalence of atrial fibrillation and flutter in the United States.

  2009cited by this paper
• Plasma fatty acid composition and incident heart failure in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study.

  2008cited by this paper
• alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction.

  2007cited by this paper
• α-Linolenic acid, Δ6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction

  2007cited by this paper
• Metabolism of alpha-linolenic acid in humans.

  2006cited by this paper
• Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio.

  2006cited by this paper
• Metabolism of α-linolenic acid in humans

  2006cited by this paper
• Intake of very long-chain n-3 fatty acids from fish and incidence of atrial fibrillation. The Rotterdam Study.

  2006cited by this paper
• N-3 Fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a randomized, controlled trial.

  2005cited by this paper
• n-3 Fatty acids consumed from fish and risk of atrial fibrillation or flutter: the Danish Diet, Cancer, and Health Study.

  2005cited by this paper
• Alpha-linolenic acid metabolism in men and women: nutritional and biological implications.

  2004cited by this paper
• Lifetime Risk for Development of Atrial Fibrillation: The Framingham Heart Study

  2004cited by this paper
• Fish intake and risk of incident atrial fibrillation.

  2004cited by this paper
• n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study.

  2003cited by this paper
• Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study.

  2001cited by this paper
• Prevention of Sudden Cardiac Death by Dietary Pure ω-3 Polyunsaturated Fatty Acids in Dogs

  1999cited by this paper
• Prevention of sudden cardiac death by dietary pure omega-3 polyunsaturated fatty acids in dogs.

  1999cited by this paper
• Impact of atrial fibrillation on the risk of death: the Framingham Heart Study.

  1998cited by this paper
• Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates.

  1998cited by this paper
• Incidence of and risk factors for atrial fibrillation in older adults.

  1997cited by this paper
• Dietary assessment using a picture-sort approach.

  1997cited by this paper
• Surveillance and ascertainment of cardiovascular events. The Cardiovascular Health Study.

  1995cited by this paper
• Dietary canola oil modifies myocardial fatty acids and inhibits cardiac arrhythmias in rats.

  1995cited by this paper
• Atrial Fibrillation in the Elderly: A Review.

  1994cited by this paper
• Cardiac arrhythmia in rats in response to dietary n-3 fatty acids from red meat, fish oil and canola oil

  1993cited by this paper
• Reproducibility and validity of food intake measurements from a semiquantitative food frequency questionnaire.

  1993cited by this paper
• The Cardiovascular Health Study: design and rationale.

  1991cited by this paper
• Direct transesterification of all classes of lipids in a one-step reaction.

  1986cited by this paper
• A simple method for the isolation and purification of total lipides from animal tissues.

  1957cited by this paper

• Plant omega-3 fatty acids may lower the risk of atrial fibrillation in individuals with a low intake of marine omega-3 fatty acids.

  2024cites this paper
• n-3 fatty acids and the risk of atrial fibrillation, review

  2024cites this paper
• Diet and risk of atrial fibrillation: a systematic review.

  2024cites this paper
• Omega-3 Fatty Acids and Arrhythmias

  2024cites this paper
• Blood pressure, hypertension and the risk of atrial fibrillation: a systematic review and meta-analysis of cohort studies

  2023cites this paper
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  2022cites this paper
• Current Evidence on Prevention of Atrial Fibrillation: Modifiable Risk Factors and the Effects of Risk Factor Intervention

  2021cites this paper
• EFFECT OF HARVESTING TIME ON HEMP (Cannabis sativa L.) SEED OIL LIPID COMPOSITION

  2020cites this paper
• Plasma Phospholipid Fatty Acids and Risk of Atrial Fibrillation: A Mendelian Randomization Study

  2019cites this paper
• Aalborg Universitet Saturated fatty acids and the risk of atrial fibrillation

  2018cites this paper
• The Burden of Cardiovascular Diseases Among US States, 1990-2016

  2018cites this paper
• Diabetes mellitus, blood glucose and the risk of atrial fibrillation: A systematic review and meta-analysis of cohort studies.

  2018cites this paper
• Polyunsaturated Fatty Acids and Their Potential Therapeutic Role in Cardiovascular System Disorders—A Review

  2018cites this paper
• Patterns of adipose tissue fatty acids and the risk of atrial fibrillation: A case-cohort study

  2018cites this paper
• Saturated fatty acids and the risk of atrial fibrillation

  2018cites this paper
• Dietary Fish and Long-Chain n-3 Polyunsaturated Fatty Acids Intake and Risk of Atrial Fibrillation: A Meta-Analysis

  2017cites this paper
• European Heart Rhythm Association (EHRA)/European Association of Cardiovascular Prevention and Rehabilitation (EACPR) position paper on how to prevent atrial fibrillation endorsed by the Heart Rhythm Society (HRS) and Asia Pacific Heart Rhythm Society (APHRS)

  2017cites this paper
• European Heart Rhythm Association (EHRA)/European Association of Cardiovascular Prevention and Rehabilitation (EACPR) position paper on how to prevent atrial fibrillation endorsed by the Heart Rhythm Society (HRS) and Asia Pacific Heart Rhythm Society (APHRS).

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
• Association of serum fatty acid and estimated desaturase activity with hypertension in middle-aged and elderly Chinese population

  2016cites this paper
• Omega-3 Fatty Acids and Cardiovascular Disease: An Updated Systematic Review.

  2016cites this paper
• Emerging Risk Biomarkers in Cardiovascular Diseases and Disorders

  2015cites this paper
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  2015cites this paper
• Indications for Omega-3 Long Chain Polyunsaturated Fatty Acid in the Prevention and Treatment of Cardiovascular Disease.

  2015cites this paper
• [CONSENSUS ON FATS AND OILS IN THE DIET OF S ISH ADULTS; POSITION PAPER OF THE SPANISH FEDERATION OF FOOD, NUTRITION AND DIETETICS SOCIETIES].

  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper