Adipose inflammation: cause or consequence of obesity-related insulin resistance

Obesity constitutes a critical risk factor for the development of many life threatening diseases, particularly insulin resistance and type 2 diabetes. Adipose tissue plays an important role in regulating whole body energy homeostatsis and obesity-related insulin resistance. Inflammation has been commonly linked to insulin resistance. Recent studies demonstrated that adipose tissue is an important source for producing inflammatory molecules in the obese state, primarily due to accumulation of macrophages. Animal models deficient in key inflammatory molecules or with reduced adipose macrophage infiltration are protected from development of obesity-related insulin resistance. Repression of adipose inflammation may be a useful approach to ameliorate obesity-associated metabolic disorders.

• Publication year

  2008

• Venue

  Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy

• Publication date

  2008-10-23

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.2147/DMSO.S4180PMID 21437153PMCID 3052712
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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