The Effect of pH on the Electrical Capacitance of Phosphatidylcholine–Phosphatidylserine System in Bilayer Lipid Membrane

This paper reports measurements on the pH dependence of the electrical capacitance of lipid membranes formed by 1:1 phosphatidylcholine-phosphatidylserine mixtures. A theoretical model was developed to describe this dependence, in which the contributions of functional groups (as the active centers of adsorption of the hydrogen and hydroxide ions) to the overall membrane capacitance were assumed to be additive. The proposed model was verified experimentally using electrochemical impedance spectroscopy. The theoretical predictions agreed with the experimental results over the measured pH range. A minimum corresponding to the isoelectric point appeared in both the theoretical equation and the experimental data.

• Publication year

  2014

• Venue

  Journal of Membrane Biology

• Publication date

  2014-02-28

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/s00232-014-9644-1PMID 24577415PMCID 3950607
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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